Search Results - "Ho, William C."

Structure of the p53 Core Domain Dimer Bound to DNA by Ho, William C., Fitzgerald, Mary X., Marmorstein, Ronen

“…The p53 tumor suppressor protein binds to DNA as a dimer of dimers to regulate transcription of genes that mediate responses to cellular stress. We have…”
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Acridine derivatives activate p53 and induce tumor cell death through bax by Wang, Wenge, Ho, William C., Dicker, David T., MacKinnon, Colin, Winkler, Jeffrey D., Marmorstein, Ronen, El-Deiry, Wafik S.

“…CP-31398 activates wild-type p53 by a novel mechanism that does not involve phosphorylation of the amino-terminus of p53 and disassociation of MDM2. To…”
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Detecting Allosteric Sites of HIV‑1 Reverse Transcriptase by X‑ray Crystallographic Fragment Screening by Bauman, Joseph D, Patel, Disha, Dharia, Chhaya, Fromer, Marc W, Ahmed, Sameer, Frenkel, Yulia, Vijayan, R. S. K, Eck, J. Thomas, Ho, William C, Das, Kalyan, Shatkin, Aaron J, Arnold, Eddy

“…HIV-1 reverse transcriptase (RT) undergoes a series of conformational changes during viral replication and is a central target for antiretroviral therapy. The…”
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Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure–Activity Analysis of Inhibitor Analogs by Himmel, Daniel M., Myshakina, Nataliya S., Ilina, Tatiana, Van Ry, Alexander, Ho, William C., Parniak, Michael A., Arnold, Eddy

“…Human immunodeficiency virus (HIV) encodes four essential enzymes: protease, integrase, reverse transcriptase (RT)-associated DNA polymerase, and RT-associated…”
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Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design by Bauman, Joseph D, Das, Kalyan, Ho, William C, Baweja, Mukta, Himmel, Daniel M, Clark, Arthur D. Jr, Oren, Deena A, Boyer, Paul L, Hughes, Stephen H, Shatkin, Aaron J, Arnold, Eddy

“…HIV-1 reverse transcriptase (RT) is a primary target for anti-AIDS drugs. Structures of HIV-1 RT, usually determined at ~2.5-3.0 Å resolution, are important…”
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Crystallographic Study of a Novel Subnanomolar Inhibitor Provides Insight on the Binding Interactions of Alkenyldiarylmethanes with Human Immunodeficiency Virus-1 Reverse Transcriptase by Cullen, Matthew D, Ho, William C, Bauman, Joseph D, Das, Kalyan, Arnold, Eddy, Hartman, Tracy L, Watson, Karen M, Buckheit, Robert W, Pannecouque, Christophe, De Clercq, Erik, Cushman, Mark

“…Two crystal structures have been solved for separate complexes of alkenyldiarylmethane (ADAM) nonnucleoside reverse transcriptase inhibitors (NNRTI) 3 and 4…”
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High-resolution structure of the p53 core domain: implications for binding small-molecule stabilizing compounds by Ho, William C., Luo, Cheng, Zhao, Kehao, Chai, Xiaomei, Fitzgerald, Mary X., Marmorstein, Ronen

“…The p53 transcriptional regulator is the most frequently mutated protein in human cancers and the majority of tumor‐derived p53 mutations map to the central…”
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Solution Structure of the Aminoacyl-Capped Oligodeoxyribonucleotide Duplex (W-TGCGCAC)2 by Ho, William C, Steinbeck, Christoph, Richert, Clemens

“…Reported here is the solution structure of the aminoacyl-DNA duplex (W-TGCGCAC)2. This duplex forms a continuously π-stacked helix consisting of both…”
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Crystal structure of a p53 core tetramer bound to DNA by Malecka, K A, Ho, W C, Marmorstein, R

“…The tumor suppressor p53 regulates downstream genes in response to many cellular stresses and is frequently mutated in human cancers. Here, we report the use…”
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Crystallographic Study of a Novel Sub-Nanomolar Inhibitor Provides Insight on the Binding Interactions of Alkenyldiarylmethanes with Human Immunodeficiency Virus-1 (HIV-1) Reverse Transcriptase by Cullen, Matthew D., Ho, William C., Bauman, Joseph D., Das, Kalyan, Arnold, Eddy, Hartman, Tracy L., Watson, Karen M., Buckheit, Robert W., Pannecouque, Christophe, De Clercq, Erik, Cushman, Mark

“…Two crystal structures have been solved for separate complexes of alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTI) 3 and 4…”
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Structural studies of the mouse p53 DNA binding domain in the presence and absence of DNA by Ho, William C

“…The p53 tumor suppressor plays a crucial role in maintaining the integrity of the genome by triggering cell death in the event of genomic stress. It functions…”
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