Search Results - "Ho, Theodore T"

Autophagy maintains the metabolism and function of young and old stem cells by Ho, Theodore T., Warr, Matthew R., Adelman, Emmalee R., Lansinger, Olivia M., Flach, Johanna, Verovskaya, Evgenia V., Figueroa, Maria E., Passegué, Emmanuelle

“…With age, haematopoietic stem cells lose their ability to regenerate the blood system, and promote disease development. Autophagy is associated with health and…”
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Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging by Leeman, Dena S, Hebestreit, Katja, Ruetz, Tyson, Webb, Ashley E, McKay, Andrew, Pollina, Elizabeth A, Dulken, Ben W, Zhao, Xiaoai, Yeo, Robin W, Ho, Theodore T, Mahmoudi, Salah, Devarajan, Keerthana, Passegué, Emmanuelle, Rando, Thomas A, Frydman, Judith, Brunet, Anne

“…In the adult brain, the neural stem cell (NSC) pool comprises quiescent and activated populations with distinct roles. Transcriptomic analysis revealed that…”
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Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions by Ho, Theodore T, Dellorusso, Paul V, Verovskaya, Evgenia V, Bakker, Sietske T, Flach, Johanna, Smith, Lucas K, Ventura, Patrick B, Lansinger, Olivia M, Hérault, Aurélie, Zhang, Si Yi, Kang, Yoon-A, Mitchell, Carl A, Villeda, Saul A, Passegué, Emmanuelle

“…While young blood can restore many aged tissues, its effects on the aged blood system itself and old hematopoietic stem cells (HSCs) have not been determined…”
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Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing by Chandel, Navdeep S., Jasper, Heinrich, Ho, Theodore T., Passegué, Emmanuelle

“…Passegué and colleagues discuss recent advances in our understanding of the metabolic control of stem cell function, and how stem cell metabolism relates to…”
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Cardiogenic control of affective behavioural state by Hsueh, Brian, Chen, Ritchie, Jo, YoungJu, Tang, Daniel, Raffiee, Misha, Kim, Yoon Seok, Inoue, Masatoshi, Randles, Sawyer, Ramakrishnan, Charu, Patel, Sneha, Kim, Doo Kyung, Liu, Tony X., Kim, Soo Hyun, Tan, Longzhi, Mortazavi, Leili, Cordero, Arjay, Shi, Jenny, Zhao, Mingming, Ho, Theodore T., Crow, Ailey, Yoo, Ai-Chi Wang, Raja, Cephra, Evans, Kathryn, Bernstein, Daniel, Zeineh, Michael, Goubran, Maged, Deisseroth, Karl

“…Emotional states influence bodily physiology, as exemplified in the top-down process by which anxiety causes faster beating of the heart 1 – 3 . However,…”
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Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis by Wong, Jasmine C, Weinfurtner, Kelley M, Alzamora, Maria Del Pilar, Kogan, Scott C, Burgess, Michael R, Zhang, Yan, Nakitandwe, Joy, Ma, Jing, Cheng, Jinjun, Chen, Shann-Ching, Ho, Theodore T, Flach, Johanna, Reynaud, Damien, Passegué, Emmanuelle, Downing, James R, Shannon, Kevin

“…Chromosome 7 deletions are highly prevalent in myelodysplastic syndrome (MDS) and likely contribute to aberrant growth through haploinsufficiency. We generated…”
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Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing by Mitchell, Carl A., Verovskaya, Evgenia V., Calero-Nieto, Fernando J., Olson, Oakley C., Swann, James W., Wang, Xiaonan, Hérault, Aurélie, Dellorusso, Paul V., Zhang, Si Yi, Svendsen, Arthur Flohr, Pietras, Eric M., Bakker, Sietske T., Ho, Theodore T., Göttgens, Berthold, Passegué, Emmanuelle

“…Haematopoietic ageing is marked by a loss of regenerative capacity and skewed differentiation from haematopoietic stem cells (HSCs), leading to impaired blood…”
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Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells by Dellorusso, Paul V, Proven, Melissa A, Calero-Nieto, Fernando J, Wang, Xiaonan, Mitchell, Carl A, Hartmann, Felix, Amouzgar, Meelad, Favaro, Patricia, DeVilbiss, Andrew, Swann, James W, Ho, Theodore T, Zhao, Zhiyu, Bendall, Sean C, Morrison, Sean, Göttgens, Berthold, Passegué, Emmanuelle

“…Autophagy is central to the benefits of longevity signaling programs and to hematopoietic stem cell (HSC) response to nutrient stress. With age, a subset of…”
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siRNA Delivery Impedes the Temporal Expression of Cytokine-Activated VCAM1 on Endothelial Cells by Ho, Theodore T., You, Jin-Oh, Auguste, Debra T.

“…Leukocyte recruitment plays a key role in chronic inflammatory diseases such as cardiovascular disease, rheumatoid arthritis, and cancer. Leukocyte rolling and…”
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Stromal inflammation is a targetable driver of hematopoietic aging by Mitchell, Carl A., Verovskaya, Evgenia V., Calero-Nieto, Fernando J., Olson, Oakley C., Swann, James W., Wang, Xiaonan, Hérault, Aurélie, Dellorusso, Paul V., Zhang, Si Yi, Svendsen, Arthur Flohr, Pietras, Eric M., Bakker, Sietske T., Ho, Theodore T., Göttgens, Berthold, Passegué, Emmanuelle

“…Hematopoietic aging is marked by a loss of regenerative capacity and skewed differentiation from hematopoietic stem cells (HSC) leading to impaired blood…”
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