Search Results - "Ho, Steffan N."

Intracellular water homeostasis and the mammalian cellular osmotic stress response by Ho, Steffan N.

“…The cellular response to osmotic stress ensures that the concentration of water inside the cell is maintained within a range that is compatible with biologic…”
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NFAT5/TonEBP Mutant Mice Define Osmotic Stress as a Critical Feature of the Lymphoid Microenvironment by Go, William Y., Liu, Xuebin, Roti, Michelle A., Liu, Forrest, Ho, Steffan N., Glimcher, Laurie H.

“…Osmotic stress responses are critical not only to the survival of unicellular organisms but also to the normal function of the mammalian kidney. However, the…”
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Multiplexed deep sequencing analysis of ALK kinase domain identifies resistance mutations in relapsed patients following crizotinib treatment by Huang, Donghui, Kim, Dong-Wan, Kotsakis, Athanasios, Deng, Shibing, Lira, Paul, Ho, Steffan N., Lee, Nathan V., Vizcarra, Pamela, Cao, Joan Q., Christensen, James G., Kim, Tae Min, Sun, Jong-mu, Ahn, Jin Seok, Ahn, Myung-Ju, Park, Keunchil, Mao, Mao

“…The recently approved ALK kinase inhibitor crizotinib has demonstrated successful treatment of metastatic and late stage ALK fusion positive non-small cell…”
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TonEBP stimulates multiple cellular pathways for adaptation to hypertonic stress: organic osmolyte-dependent and -independent pathways by Lee, Sang Do, Choi, Soo Youn, Lim, Sun Woo, Lamitina, S Todd, Ho, Steffan N, Go, William Y, Kwon, H Moo

“…TonEBP (tonicity-responsive enhancer binding protein) is a transcription factor that promotes cellular accumulation of organic osmolytes in the hypertonic…”
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combinatorial role for NFAT5 in both myoblast migration and differentiation during skeletal muscle myogenesis by O'Connor, Roddy S, Mills, Stephen T, Jones, Kristen A, Ho, Steffan N, Pavlath, Grace K

“…Skeletal muscle regeneration depends on myoblast migration, differentiation and myofiber formation. Isoforms of the nuclear factor of activated T cells (NFAT)…”
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Combination of two insulin-like growth factor-I receptor inhibitory antibodies targeting distinct epitopes leads to an enhanced antitumor response by Dong, Jianying, Demarest, Stephen J, Sereno, Arlene, Tamraz, Susan, Langley, Emma, Doern, Adam, Snipas, Tracey, Perron, Keli, Joseph, Ingrid, Glaser, Scott M, Ho, Steffan N, Reff, Mitchell E, Hariharan, Kandasamy

“…The insulin-like growth factor-I receptor (IGF-IR) is a cell surface receptor tyrosine kinase that mediates cell survival signaling and supports tumor…”
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New methods for ALK status diagnosis in non-small-cell lung cancer: an improved ALK immunohistochemical assay and a new, Brightfield, dual ALK IHC-in situ hybridization assay by Nitta, Hiroaki, Tsuta, Koji, Yoshida, Akihiko, Ho, Steffan N, Kelly, Brian D, Murata, Lauren B, Kosmeder, Jerry, White, Katie, Ehser, Sandra, Towne, Penny, Schemp, Crystal, McElhinny, Abigail, Ranger-Moore, Jim, Bieniarz, Chris, Singh, Shalini, Tsuda, Hitoshi, Grogan, Thomas M

“…The demonstration of anaplastic lymphoma kinase (ALK) positivity in non-small-cell lung cancer (NSCLC) has been hindered by the technical complexity and…”
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Calcineurin-NFATc signaling pathway regulates AQP2 expression in response to calcium signals and osmotic stress by Li, Song-Zhe, McDill, Bradley W, Kovach, Paul A, Ding, Li, Go, William Y, Ho, Steffan N, Chen, Feng

“…The aquaporin (AQP)2 channel mediates the reabsorption of water in renal collecting ducts in response to arginine vasopressin (AVP) and hypertonicity. Here we…”
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TWEAK signals through JAK–STAT to induce tumor cell apoptosis by Chapman, Mark S., Wu, Lan, Amatucci, Aldo, Ho, Steffan N., Michaelson, Jennifer S.

“…► IFNγ enhancement of TWEAK/Fn14-mediated apoptosis requires JAK–STAT signaling. ► IFNγ treatment results in upregulation of Fn14 expression on tumor cells. ►…”
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Gene Splicing by Overlap Extension: Tailor-Made Genes Using the Polymerase Chain Reaction by Robert M. Horton, Zeling Cai, Steffan N. Ho, Larry R. Pease

“…Gene Splicing by Overlap Extension or “gene SOEing” is a PCR-based method of recombining DNA sequences without reliance on restriction sites and of directly…”
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A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity by Dong, Jianying, Sereno, Arlene, Aivazian, Dikran, Langley, Emma, Miller, Brian R., Snyder, William B, Chan, Eric, Cantele, Matt, Morena, Ronald, Joseph, Ingrid B.J.K., Boccia, Antonio, Virata, Cyrus, Gamez, James, Yco, Grace, Favis, Michael, Wu, Xiufeng, Graff, Christilyn P., Wang, Qin, Rohde, Ellen, Rennard, Rachel, Berquist, Lisa, Huang, Flora, Zhang, Ying, Gao, Sharon X., Ho, Steffan N., Demarest, Stephen J., Reff, Mitchell E., Hariharan, Kandasamy, Glaser, Scott M.

“…The epidermal growth factor receptor (EGFR) and the type I insulin-like growth factor receptor (IGF-1R) are two cell surface receptor tyrosine kinases known to…”
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CD80 (B7.1) is expressed on both malignant B cells and nonmalignant stromal cells in non‐Hodgkin lymphoma by Dakappagari, Naveen, Ho, Steffan N., Gascoyne, Randy D., Ranuio, Julie, Weng, Andrew P., Tangri, Shabnam

“…Background: CD80 is a member of the B7 family of immune coregulatory proteins that mediate both immune activation and suppression. CD80 in particular has…”
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A Sensitive ALK Immunohistochemistry Companion Diagnostic Test Identifies Patients Eligible for Treatment with Crizotinib by Thorne-Nuzzo, Trish, Williams, Crystal, Catallini, Alice, Clements, June, Singh, Shalini, Amberson, James, Dickinson, Kim, Gatalica, Zoran, Ho, Steffan N, Loftin, Isabell, McElhinny, Abigail, Towne, Penny

“…The availability of high-quality, rigorously validated diagnostic tests that can be broadly implemented is necessary to efficiently identify patients with…”
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Phase I Results from a Study of Crizotinib in Combination with Erlotinib in Patients with Advanced Nonsquamous Non-Small Cell Lung Cancer by Ou, Sai-Hong Ignatius, Govindan, Ramaswamy, Eaton, Keith D, Otterson, Gregory A, Gutierrez, Martin E, Mita, Alain C, Argiris, Athanassios, Brega, Nicoletta M, Usari, Tiziana, Tan, Weiwei, Ho, Steffan N, Robert, Francisco

“…This phase I trial was conducted to determine the safety, maximum tolerated dose (MTD)/recommended phase II dose, and efficacy of crizotinib plus erlotinib in…”
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A phase II, single-arm study of the anti-α5β1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer by Bell-McGuinn, Katherine M, Matthews, Carolyn M, Ho, Steffan N, Barve, Minal, Gilbert, Lucy, Penson, Richard T, Lengyel, Ernst, Palaparthy, Rameshraja, Gilder, Kye, Vassos, Artemios, McAuliffe, William, Weymer, Sara, Barton, Jeremy, Schilder, Russell J

“…Abstract Objective This phase II, multicenter, single-arm, two-stage study in platinum-resistant, advanced epithelial ovarian or primary peritoneal cancer…”
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Correction to: The Cancer Research UK Stratified Medicine Programme as a model for delivering personalised cancer care by Cerone, Maria Antonietta, Mills, Tara C., Sharpe, Rowena, McBride, David, MacDonald, Moira, MacMahon, Suzanne, Mugalaasi, Hood, Rehal, Pauline, Rettino, Alessandro, Roberts, Helen, Ross, Mark, White, Donald Edward, Peden, John, Rawlinson, Janette, Ho, Steffan N., Hollingsworth, Simon, Popat, Sanjay, Middleton, Gary, Johnson, Peter, Swanton, Charles

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The Cancer Research UK Stratified Medicine Programme as a model for delivering personalised cancer care by Cerone, Maria Antonietta, Mills, Tara C., Sharpe, Rowena, McBride, David, MacDonald, Moira, MacMahon, Suzanne, Mugalaasi, Hood, Rehal, Pauline, Rettino, Alessandro, Roberts, Helen, Ross, Mark, White, Donald Edward, Peden, John, Rawlinson, Janette, Ho, Steffan N., Hollingsworth, Simon, Popat, Sanjay, Middleton, Gary, Johnson, Peter, Swanton, Charles

“…Summary Genomic screening is routinely used to guide the treatment of cancer patients in many countries. However, several multi-layered factors make this…”
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Site-directed mutagenesis by overlap extension using the polymerase chain reaction by Ho, S N, Hunt, H D, Horton, R M, Pullen, J K, Pease, L R

“…Overlap extension represents a new approach to genetic engineering. Complementary oligodeoxyribonucleotide (oligo) primers and the polymerase chain reaction…”
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Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc by Wolfe, Scot A, Zhou, Pei, Dötsch, Volker, Chen, Lin, You, Angie, Ho, Steffan N, Crabtree, Gerald R, Wagner, Gerhard, Verdine, Gregory L

“…Transcription factors of the NFAT family regulate the production of effector proteins that coordinate the immune response. The immunosuppressive drugs FK506…”
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The role of NFAT5/TonEBP in establishing an optimal intracellular environment by Ho, Steffan N

“…NFAT5/TonEBP, the most recently described member of the rel/NFκB/NFAT family of signal-dependent transcription factors, is activated by extracellular…”
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