Search Results - "Ho, Patricia W M"

EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis by Tonna, Stephen, Takyar, Farzin M., Vrahnas, Christina, Crimeen‐Irwin, Blessing, Ho, Patricia W. M., Poulton, Ingrid J., Brennan, Holly J., McGregor, Narelle E., Allan, Elizabeth H., Nguyen, Huynh, Forwood, Mark R., Tatarczuch, Liliana, Mackie, Eleanor J., Martin, T. John, Sims, Natalie A.

“…Cells that form bone (osteoblasts) express both ephrinB2 and EphB4, and previous work has shown that pharmacological inhibition of the eph‐rinB2/EphB4…”
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EphrinB2/EphB4 inhibition in the osteoblast lineage modifies the anabolic response to parathyroid hormone by Takyar, Farzin M, Tonna, Stephen, Ho, Patricia WM, Crimeen‐Irwin, Blessing, Baker, Emma K, Martin, T John, Sims, Natalie A

“…Previous reports indicate that ephrinB2 expression by osteoblasts is stimulated by parathyroid hormone (PTH) and its related protein (PTHrP) and that…”
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Correction: Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification by Tonna, Stephen, Poulton, Ingrid J, Taykar, Farzin, Ho, Patricia W M, Tonkin, Brett, Crimeen-Irwin, Blessing, Tatarczuch, Liliana, McGregor, Narelle E, Mackie, Eleanor J, Martin, T John, Sims, Natalie A

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Sustained RANKL response to parathyroid hormone in oncostatin M receptor-deficient osteoblasts converts anabolic treatment to a catabolic effect in vivo by Walker, Emma C, Poulton, Ingrid J, McGregor, Narelle E, Ho, Patricia WM, Allan, Elizabeth H, Quach, Julie M, Martin, T John, Sims, Natalie A

“…Parathyroid hormone (PTH) is the only approved anabolic agent for osteoporosis treatment. It acts via osteoblasts to stimulate both osteoclast formation and…”
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gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation by Standal, Therese, Johnson, Rachelle W, McGregor, Narelle E, Poulton, Ingrid J, Ho, Patricia W M, Martin, T John, Sims, Natalie A

“…Parathyroid hormone (PTH) treatment stimulates osteoblast differentiation and bone formation, and is the only currently approved anabolic therapy for…”
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Autocrine and Paracrine Regulation of the Murine Skeleton by Osteocyte‐Derived Parathyroid Hormone‐Related Protein by Ansari, Niloufar, Ho, Patricia WM, Crimeen‐Irwin, Blessing, Poulton, Ingrid J, Brunt, Athena R, Forwood, Mark R, Divieti Pajevic, Paola, Gooi, Jonathan H, Martin, T John, Sims, Natalie A

“…ABSTRACT Parathyroid hormone–related protein (PTHrP) and parathyroid hormone (PTH) have N‐terminal domains that bind a common receptor, PTHR1. N‐terminal PTH…”
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Parathyroid Hormone-Related Protein Negatively Regulates Tumor Cell Dormancy Genes in a PTHR1/Cyclic AMP-Independent Manner by Johnson, Rachelle W, Sun, Yao, Ho, Patricia W M, Chan, Audrey S M, Johnson, Jasmine A, Pavlos, Nathan J, Sims, Natalie A, Martin, T John

“…Parathyroid hormone-related protein (PTHrP) expression in breast cancer is enriched in bone metastases compared to primary tumors. Human MCF7 breast cancer…”
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Thiophene inhibitors of PDE4: Crystal structures show a second binding mode at the catalytic domain of PDE4D2 by Nankervis, Jacob L., Feil, Susanne C., Hancock, Nancy C., Zheng, Zhaohua, Ng, Hooi-Ling, Morton, Craig J., Holien, Jessica K., Ho, Patricia W.M., Frazzetto, Mark M., Jennings, Ian G., Manallack, David T., John Martin, T., Thompson, Philip E., Parker, Michael W.

“…PDE4 inhibitors have been identified as therapeutic targets for a variety of conditions, particularly inflammatory diseases. We have serendipitously identified…”
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Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA by Mutsaers, Anthony J, Ng, Alvin J.M, Baker, Emma K, Russell, Megan R, Chalk, Alistair M, Wall, Meaghan, Liddicoat, Brain J.J, Ho, Patricia W.M, Slavin, John L, Goradia, Ankita, Martin, T. John, Purton, Louise E, Dickins, Ross A, Walkley, Carl R

“…Abstract Osteosarcoma is the most common primary cancer of bone and one that predominantly affects children and adolescents. Osteoblastic osteosarcoma…”
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Identification of a Parathyroid Hormone in the Fish Fugu rubripes by Danks, Janine A, Ho, Patricia MW, Notini, Amanda J, Katsis, Frosa, Hoffmann, Peter, Kemp, Bruce E, Martin, T John, Zajac, Jeffrey D

“…A PTH gene has been isolated from the fish Fugu rubripes. The encoded protein of 80 amino acid has the lowest homology with any of the PTH family members. Fugu…”
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IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis by McGregor, Narelle E., Murat, Melissa, Elango, Jeevithan, Poulton, Ingrid J., Walker, Emma C., Crimeen-Irwin, Blessing, Ho, Patricia W.M., Gooi, Jonathan H., Martin, T. John, Sims, Natalie A.

“…Interleukin 6 (IL-6) supports development of bone-resorbing osteoclasts by acting early in the osteoblast lineage via membrane-bound (cis) or soluble (trans)…”
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Structural Basis for Antibody Discrimination between Two Hormones That Recognize the Parathyroid Hormone Receptor by McKinstry, William J., Polekhina, Galina, Diefenbach-Jagger, Hannelore, Ho, Patricia W.M., Sato, Koh, Onuma, Etsuro, Gillespie, Matthew T., Martin, T. John, Parker, Michael W.

“…Parathyroid hormone-related protein (PTHrP) plays a vital role in the embryonic development of the skeleton and other tissues. When it is produced in excess by…”
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Dmp1Cre‐directed knockdown of parathyroid hormone–related protein (PTHrP) in murine decidua is associated with a life‐long increase in bone mass, width, and strength in male progeny by Ansari, Niloufar, Isojima, Tsuyoshi, Crimeen‐Irwin, Blessing, Poulton, Ingrid J., McGregor, Narelle E., Ho, Patricia W. M., Forwood, Mark R., Kovacs, Christopher S., Dimitriadis, Evdokia, Gooi, Jonathan H., Martin, T. John, Sims, Natalie A.

“…ABSTRACT Parathyroid hormone–related protein (PTHrP, gene name Pthlh) is a pleiotropic regulator of tissue homeostasis. In bone, Dmp1Cre‐targeted PTHrP…”
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Brief exposure to full length parathyroid hormone-related protein (PTHrP) causes persistent generation of cyclic AMP through an endocytosis-dependent mechanism by Ho, Patricia W.M., Chan, Audrey S., Pavlos, Nathan J., Sims, Natalie A., Martin, T. John

“…[Display omitted] Parathyroid hormone (PTH)-related protein (PTHrP) (gene name Pthlh) was discovered as the factor responsible for the humoral hypercalcemia of…”
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Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification by Tonna, Stephen, Poulton, Ingrid J, Taykar, Farzin, Ho, Patricia W M, Tonkin, Brett, Crimeen-Irwin, Blessing, Tatarczuch, Liliana, McGregor, Narelle E, Mackie, Eleanor J, Martin, T John, Sims, Natalie A

“…The majority of the skeleton arises by endochondral ossification, whereby cartilaginous templates expand and are resorbed by osteoclasts then replaced by…”
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Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53 by Walia, Mannu K., Taylor, Scott, Ho, Patricia W. M., Martin, T. John, Walkley, Carl R.

“…The loss of p53 function is a central event in the genesis of osteosarcoma (OS). How mutation of p53 enables OS development from osteoblastic lineage cells is…”
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Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance by Walia, Mannu K, Ho, Patricia Mw, Taylor, Scott, Ng, Alvin Jm, Gupte, Ankita, Chalk, Alistair M, Zannettino, Andrew Cw, Martin, T John, Walkley, Carl R

“…Mutations in the P53 pathway are a hallmark of human cancer. The identification of pathways upon which p53-deficient cells depend could reveal therapeutic…”
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BMP-2 regulation of PTHrP and osteoclastogenic factors during osteoblast differentiation of C2C12 cells by Susperregui, Antonio R.G., Viñals, Francesc, Ho, Patricia W.M., Gillespie, Matthew T., Martin, T. John, Ventura, Francesc

“…Bone morphogenetic protein‐2 (BMP‐2) is strongly involved in the induction of osteoblast differentiation from mesenchymal cell precursors, as well as in…”
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Reduced fetal, placental, and amniotic fluid PTHrP in the growth-restricted spontaneously hypertensive rat by Wlodek, M E, Westcott, K T, Ho, P W, Serruto, A, Di Nicolantonio, R, Farrugia, W, Moseley, J M

“…Evidence implicates pivotal roles for parathyroid hormone-related protein (PTHrP) in stimulating cell growth and differentiation, placental calcium transport,…”
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Parathyroid hormone-related protein: a possible endocrine function in lactation by Grill, V, Hillary, J, Ho, P M, Law, F M, MacIsaac, R J, MacIsaac, I A, Moseley, J M, Martin, T J

“…Parathyroid hormone-related protein (PTHrP), initially discovered as the factor responsible for the syndrome of humoral hypercalcaemia of malignancy, has also…”
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