Search Results - "Ho, P Shing"

Definition of the halogen bond (IUPAC Recommendations 2013) by Desiraju, Gautam R., Ho, P. Shing, Kloo, Lars, Legon, Anthony C., Marquardt, Roberto, Metrangolo, Pierangelo, Politzer, Peter, Resnati, Giuseppe, Rissanen, Kari

“…This recommendation proposes a definition for the term “halogen bond”, which designates a specific subset of the inter- and intramolecular interactions…”
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Computational Tools To Model Halogen Bonds in Medicinal Chemistry by Ford, Melissa Coates, Ho, P. Shing

“…The use of halogens in therapeutics dates back to the earliest days of medicine when seaweed was used as a source of iodine to treat goiters. The incorporation…”
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Halogen bonding (X‐bonding): A biological perspective by Scholfield, Matthew R., Zanden, Crystal M. Vander, Carter, Megan, Ho, P. Shing

“…The concept of the halogen bond (or X‐bond) has become recognized as contributing significantly to the specificity in recognition of a large class of…”
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Structure of the Holliday junction: applications beyond recombination by Ho, P Shing

“…The Holliday junction (HJ) is an essential element in recombination and related mechanisms. The structure of this four-stranded DNA assembly, which is now…”
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Halogen bonds as orthogonal molecular interactions to hydrogen bonds by Ho, P. Shing, Voth, Andrea Regier, Khuu, Patricia, Oishi, Keita

“…Halogen bonds (X-bonds) are shown to be geometrically perpendicular to and energetically independent of hydrogen bonds (H-bonds) that share a common carbonyl…”
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Increasing Enzyme Stability and Activity through Hydrogen Bond-Enhanced Halogen Bonds by Carlsson, Anna-Carin C, Scholfield, Matthew R, Rowe, Rhianon K, Ford, Melissa Coates, Alexander, Austin T, Mehl, Ryan A, Ho, P. Shing

“…The construction of more stable proteins is important in biomolecular engineering, particularly in the design of biologics-based therapeutics. We show here…”
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Directing macromolecular conformation through halogen bonds by Voth, Andrea Regier, Hays, Franklin A, Ho, P. Shing

“…The halogen bond, a noncovalent interaction involving polarizable chlorine, bromine, or iodine molecular substituents, is now being exploited to control the…”
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Structure–Energy Relationships of Halogen Bonds in Proteins by Scholfield, Matthew R, Ford, Melissa Coates, Carlsson, Anna-Carin C, Butta, Hawera, Mehl, Ryan A, Ho, P. Shing

“…The structures and stabilities of proteins are defined by a series of weak noncovalent electrostatic, van der Waals, and hydrogen bond (HB) interactions. In…”
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Biomolecular halogen bonds by Ho, P Shing

“…Halogens are atypical elements in biology, but are common as substituents in ligands, including thyroid hormones and inhibitors, which bind specifically to…”
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A Biological Take on Halogen Bonding and Other Non‐Classical Non‐Covalent Interactions by Czarny, Ryan S., Ho, Alexander N., Shing Ho, P.

“…Classical hydrogen bonds have, for many decades, been the dominant non‐covalent interaction in the toolbox that chemists and chemical engineers have used to…”
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Halogen Bonds in Biological Molecules by Auffinger, Pascal, Hays, Franklin A., Westhof, Eric, Ho, P. Shing, Van Holde, K. E.

“…Short oxygen-halogen interactions have been known in organic chemistry since the 1950s and recently have been exploited in the design of supramolecular…”
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Sulfur as an Acceptor to Bromine in Biomolecular Halogen Bonds by Ford, Melissa Coates, Saxton, Matthew, Ho, P. Shing

“…The halogen bond (X-bond) has become an important design element in chemistry, including medicinal chemistry and biomolecular engineering. Although oxygen is…”
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Relationships between hydrogen bonds and halogen bonds in biological systems by Rowe, Rhianon K., Ho, P. Shing

“…The recent recognition that halogen bonding (XB) plays important roles in the recognition and assembly of biological molecules has led to new approaches in…”
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Phylogenomic analysis of the emergence of GC-rich transcription elements by Khuu, Patricia, Sandor, Maurice, DeYoung, Jennifer, Ho, P. Shing

“…We have applied a comparative phylogenomic analysis to study the evolutionary relationships between GC content, CpG-dinucleotide content (CpGs), potential…”
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A Functional Interplay between Human Immunodeficiency Virus Type 1 Protease Residues 77 and 93 Involved in Differential Regulation of Precursor Autoprocessing and Mature Protease Activity by Counts, Christopher J, Ho, P Shing, Donlin, Maureen J, Tavis, John E, Chen, Chaoping

“…HIV-1 protease (PR) is a viral enzyme vital to the production of infectious virions. It is initially synthesized as part of the Gag-Pol polyprotein precursor…”
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How Sequence Defines Structure: A Crystallographic Map of DNA Structure and Conformation by Hays, Franklin A., Teegarden, Amy, Zebulon J. R. Jones, Harms, Michael, Raup, Dustin, Watson, Jeffrey, Cavaliere, Emily, Ho, P. Shing, Rich, Alexander

“…The fundamental question of how sequence defines conformation is explicitly answered if the structures of all possible sequences of a macromolecule are…”
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Mass Spectrometric Approaches Using Electrospray Ionization Charge States and Hydrogen-Deuterium Exchange for Determining Protein Structures and Their Conformational Changes by Yan, Xuguang, Watson, Jeffrey, Ho, P Shing, Deinzer, Max L

“…Electrospray ionization (ESI) mass spectrometry (MS) is a powerful analytical tool for elucidating structural details of proteins in solution especially when…”
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Distributions of Z-DNA and nuclear factor I in human chromosome 22: a model for coupled transcriptional regulation by Champ, P. Christoph, Maurice, Sandor, Vargason, Jeffrey M., Camp, Tracy, Ho, P. Shing

“…An analysis of the human chromosome 22 genomic sequence shows that both Z-DNA forming regions (ZDRs) and promoter sites for nuclear factor-I (NFI) are…”
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The Holliday Junction in an Inverted Repeat DNA Sequence: Sequence Effects on the Structure of Four-Way Junctions by Eichman, Brandt F., Vargason, Jeffrey M., Blaine H. M. Mooers, Ho, P. Shing

“…Holliday junctions are important structural intermediates in recombination, viral integration, and DNA repair. We present here the single-crystal structure of…”
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Non‐classical Non‐covalent σ‐Hole Interactions in Protein Structure and Function: Concepts for Potential Protein Engineering Applications by Walker, Margaret G., Mendez, C. Gustavo, Ho, P. Shing

“…The structures and associated functions of biological molecules are driven by noncovalent interactions, which have classically been dominated by the hydrogen…”
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