Search Results - "Ho, Norman F.H."

Mechanistic roles of neutral surfactants on concurrent polarized and passive membrane transport of a model peptide in Caco-2 cells by Nerurkar, M M, Ho, N F, Burton, P S, Vidmar, T J, Borchardt, R T

“…The transport of the model peptide Acf(NMef)2NH2 across Caco-2 cell monolayers was studied in the apical (AP) to basolateral (BL) and the BL to AP direction in…”
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How structural features influence the biomembrane permeability of peptides by Burton, P S, Conradi, R A, Ho, N F, Hilgers, A R, Borchardt, R T

“…Successful drug development requires not only optimization of specific and potent pharmacological activity at the target site, but also efficient delivery to…”
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Quantitative approaches to delineate paracellular diffusion in cultured epithelial cell monolayers by Adson, A, Raub, T J, Burton, P S, Barsuhn, C L, Hilgers, A R, Audus, K L, Ho, N F

“…When using cultured cell monolayers to determine the mechanism of transcellular diffusion of molecules, it may be important to identify the fraction that moves…”
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Passive diffusion of weak organic electrolytes across Caco-2 cell monolayers: uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers by Adson, A, Burton, P S, Raub, T J, Barsuhn, C L, Audus, K L, Ho, N F

“…A systematic approach was used to demonstrate the quantitative interplay of pH, pKa, lipophilicity, charged and uncharged molecular species, molecular size,…”
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Absorption and intestinal metabolism of purine dideoxynucleosides and an adenosine deaminase-activated prodrug of 2',3'-dideoxyinosine in the mesenteric vein cannulated rat ileum by Singhal, D, Ho, N F, Anderson, B D

“…This study investigates the mechanisms of absorption and the role of intestinally localized purine salvage pathway enzymes on the ileal availabilities of…”
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Absorption of Unconjugated Bile Acids from the Perfused Jejunum of the Anesthetized Rat: Structure–Activity Relationships and Rate‐Limiting Steps by Dupas, Jean‐Louis, Ho, Norman F.H., Hofmann, Alan F.

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Transport of model peptides across Ascaris suum cuticle by Sheehy, Barbara A, Ho, Norman F.H, Burton, Philip S, Day, Jeffrey S, Geary, Timothy G, Thompson, David P

“…Several FMRFamide-related peptides (FaRPs) found in nematodes exert potent excitatory or inhibitory effects on the somatic musculature of Ascaris suum and…”
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Quantitative and Mechanistic Assessment of Model Lipophilic Drugs in Micellar Solutions in the Transport Kinetics Across MDR1-MDCK Cell Monolayers by Ho, Norman F H, Nielsen, James, Peterson, Michelle, Burton, Philip S

“…An approach to characterizing P-glycoprotein (Pgp) interaction potential for sparingly water-soluble compounds was developed using bidirectional transport…”
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Capric Acid Absorption in the Presence of Hydroxypropyl-β-Cyclodextrin in the Rat Ileum using the In Situ Single-Pass Perfusion Technique by Hymas, Richard V, Ho, Norman F H, Higuchi, William I

“…The purpose of the present study was to gain quantitative mechanistic insight into the role cyclodextrin carriers may play in the intestinal absorption of…”
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Biophysical model for organic acid excretion in Ascaris suum by Blair, K.L, Barsuhn, C.L, Day, J.S, Ho, N.F.H, Geary, T.G, Thompson, D.P

“…To develop a model for the mechanisms of organic acid excretion in nematodes, we measured the concentrations of volatile fatty acids (VFAs), pH and electrical…”
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Theoretical and experimental studies of transport of micelle-solubilized solutes by Amidon, G E, Higuchi, W I, Ho, N F

“…A physical model describing the simultaneous diffusion of free solute and micelle-solubilized solute across the aqueous boundary layer, coupled with…”
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Transport of a lipophilic ionizable permeant (capric acid) across a lipophilic membrane (silicone polymer membrane) from aqueous buffered solutions in the presence of hydroxypropyl-β-cyclodextrin by Hymas, Richard V, Ho, Norman F H, Higuchi, William I

“…The present study describes a physical model approach applicable to understanding the transport of highly lipophilic, ionizable drugs across a lipophilic…”
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Systematic studies on the paracellular permeation of model permeants and oligonucleotides in the rat small intestine with chenodeoxycholate as enhancer by Tsutsumi, Keiko, Li, S Kevin, Hymas, Richard V, Teng, Ching-Leou, Tillman, Lloyd G, Hardee, Gregory E, Higuchi, William I, Ho, Norman F H

“…The objective of this study was to mechanistically and quantitatively analyze chenodeoxycholate-enhanced paracellular transport of polar permeants and…”
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Hydration and Percutaneous Absorption: I. Influence of Hydration on Alkanol Permeation Through Hairless Mouse Skin by Behl, Charanjit R., Flynn, Gordon L., Kurihara, Tamie, Harper, Nancy, Smith, Ward, Higuchi, William I., Ho, Norman F.H., Pierson, Carl L.

“…A method to study the influence of hydration on skin permeability where the skin is immersed in saline for up to 30hr and under circumstances where a steady…”
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Permeation of mouse skin and silicone rubber membranes by phenols: relationship to in vitro partitioning by Jetzer, W E, Huq, A S, Ho, N F, Flynn, G L, Duraiswamy, N, Condie, Jr, L

“…A discrepancy has been noted in the relationship between the relative skin permeabilities of phenols and their lipophilicities as expressed in commonly used…”
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Paracellular diffusion in Caco-2 cell monolayers: effect of perturbation on the transport of hydrophilic compounds that vary in charge and size by Knipp, G T, Ho, N F, Barsuhn, C L, Borchardt, R T

“…We applied the principles of molecular-size-restricted diffusion within a negative electrostatic field of force to follow the changes in the aqueous pore…”
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Physical model evaluation of topical prodrug delivery--simultaneous transport and bioconversion of vidarabine-5'-valerate IV: Distribution of esterase and deaminase enzymes in hairless mouse skin by Yu, C D, Fox, J L, Higuchi, W I, Ho, N F

“…A semiquantitative assessment of estrase and deaminase distributions in hairless mouse skin was performed in vitro. The enzyme activities were quantified using…”
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A systematic examination of the in vitro Ussing chamber and the in situ single-pass perfusion model systems in rat ileum permeation of model solutes by Tsutsumi, Keiko, Li, S Kevin, Ghanem, Abdel-Halim, Ho, Norman F H, Higuchi, William I

“…In situ and in vitro intestinal absorption in the rat ileum was systematically studied and mechanistically quantified in terms of permeability coefficients (P)…”
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Physical model evaluation of topical prodrug delivery--simultaneous transport and bioconversion of vidarabine-5'-valerate V: Mechanistic analysis of influence of nonhomogeneous enzyme distributions in hairless mouse skin by Yu, C D, Gordon, N A, Fox, J L, Higuchi, W I, Ho, N F

“…The mathematical problem of simultaneous transport and metabolism in the case of nonuniform enzyme distributions in the skin was solved, and the solutions were…”
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Physical model evaluation of topical prodrug delivery--simultaneous transport and bioconversion of vidarabine-5'-valerate III: Permeability differences of vidarabine and n-pentanol in components of hairless mouse skin by Yu, C D, Higuchi, W I, Ho, N F, Fox, J L, Flynn, G L

“…The permeation behavior of 3H-vidarabine (3H-9-beta-D-ara-binofuranosyladenine) and 14C-n-pentanol through different strata of hairless mouse skin was studied…”
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