Search Results - "Ho, Li‐Lun"

Evolution of delayed resistance to immunotherapy in a melanoma responder by Liu, David, Lin, Jia-Ren, Robitschek, Emily J., Kasumova, Gyulnara G., Heyde, Alex, Shi, Alvin, Kraya, Adam, Zhang, Gao, Moll, Tabea, Frederick, Dennie T., Chen, Yu-An, Wang, Shu, Schapiro, Denis, Ho, Li-Lun, Bi, Kevin, Sahu, Avinash, Mei, Shaolin, Miao, Benchun, Sharova, Tatyana, Alvarez-Breckenridge, Christopher, Stocking, Jackson H., Kim, Tommy, Fadden, Riley, Lawrence, Donald, Hoang, Mai P., Cahill, Daniel P., Malehmir, Mohsen, Nowak, Martin A., Brastianos, Priscilla K., Lian, Christine G., Ruppin, Eytan, Izar, Benjamin, Herlyn, Meenhard, Van Allen, Eliezer M., Nathanson, Katherine, Flaherty, Keith T., Sullivan, Ryan J., Kellis, Manolis, Sorger, Peter K., Boland, Genevieve M.

“…Despite initial responses 1 – 3 , most melanoma patients develop resistance 4 to immune checkpoint blockade (ICB). To understand the evolution of resistance,…”
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Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity by Kim, Tae-Hee, Li, Fugen, Ferreiro-Neira, Isabel, Ho, Li-Lun, Luyten, Annouck, Nalapareddy, Kodandaramireddy, Long, Henry, Verzi, Michael, Shivdasani, Ramesh A.

“…A study investigating the mechanisms underlying lateral inhibition and lineage plasticity in the mouse small intestine crypts in vivo finds that crypt cells…”
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Epigenomic dissection of Alzheimer’s disease pinpoints causal variants and reveals epigenome erosion by Xiong, Xushen, James, Benjamin T., Boix, Carles A., Park, Yongjin P., Galani, Kyriaki, Victor, Matheus B., Sun, Na, Hou, Lei, Ho, Li-Lun, Mantero, Julio, Scannail, Aine Ni, Dileep, Vishnu, Dong, Weixiu, Mathys, Hansruedi, Bennett, David A., Tsai, Li-Huei, Kellis, Manolis

“…Recent work has identified dozens of non-coding loci for Alzheimer’s disease (AD) risk, but their mechanisms and AD transcriptional regulatory circuitry are…”
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Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix by Nigro, Pasquale, Vamvini, Maria, Yang, Jiekun, Caputo, Tiziana, Ho, Li-Lun, Carbone, Nicholas P., Papadopoulos, Danae, Conlin, Royce, He, Jie, Hirshman, Michael F., White, Joseph D., Robidoux, Jacques, Hickner, Robert C., Nielsen, Søren, Pedersen, Bente K., Kellis, Manolis, Middelbeek, Roeland J.W., Goodyear, Laurie J.

“…Inguinal white adipose tissue (iWAT) is essential for the beneficial effects of exercise training on metabolic health. The underlying mechanisms for these…”
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Essential and Redundant Functions of Caudal Family Proteins in Activating Adult Intestinal Genes by Verzi, Michael P., Shin, Hyunjin, Ho, Li-Lun, Liu, X. Shirley, Shivdasani, Ramesh A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Control of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor, Mats by Lai, Zhi-Chun, Wei, Xiaomu, Shimizu, Takeshi, Ramos, Edward, Rohrbaugh, Margaret, Nikolaidis, Nikolas, Ho, Li-Lun, Li, Ying

“…Appropriate cell number and organ size in a multicellular organism are determined by coordinated cell growth, proliferation, and apoptosis. Disruption of these…”
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Comprehensive analysis of intercellular communication in the thermogenic adipose niche by Shamsi, Farnaz, Zheng, Rongbin, Ho, Li-Lun, Chen, Kaifu, Tseng, Yu-Hua

“…Brown adipose tissue (BAT) is responsible for regulating body temperature through adaptive thermogenesis. The ability of thermogenic adipocytes to dissipate…”
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DOT1L-Mediated H3K79 Methylation in Chromatin Is Dispensable for Wnt Pathway-Specific and Other Intestinal Epithelial Functions by Ho, Li-Lun, Sinha, Amit, Verzi, Michael, Bernt, Kathrin M., Armstrong, Scott A., Shivdasani, Ramesh A.

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mob as tumor suppressor gene is essential for early development and regulates tissue growth in Drosophila by Shimizu, T, Ho, L.L, Lai, Z.C

“…Studies in Drosophila have defined a new growth inhibitory pathway mediated by Fat (Ft), Merlin (Mer), Expanded (Ex), Hippo (Hpo), Salvador (Sav)/Shar-pei,…”
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Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells by Yang, Jiekun, Vamvini, Maria, Nigro, Pasquale, Ho, Li-Lun, Galani, Kyriakitsa, Alvarez, Marcus, Tanigawa, Yosuke, Renfro, Ashley, Carbone, Nicholas P., Laakso, Markku, Agudelo, Leandro Z., Pajukanta, Päivi, Hirshman, Michael F., Middelbeek, Roeland J.W., Grove, Kevin, Goodyear, Laurie J., Kellis, Manolis

“…Exercise training is critical for the prevention and treatment of obesity, but its underlying mechanisms remain incompletely understood given the challenge of…”
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Inhibiting ADAM10‐MMP14 Complex Blocks Cystogenesis of Kidney Epithelial Cells by Xu, Frank, Ho, Li‐Lun, Lin, You‐Hsien H., Lu, Tzongshi

“…Background Polycystic kidney disease (PKD) is the most common genetic kidney disorder. It is characterized by the aberrant renal tubule epithelial cells…”
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The effects of disease severity, use of corticosteroids and social factors on neuropsychiatric complaints in severe acute respiratory syndrome (SARS) patients at acute and convalescent phases by Sheng, Bun, Wing Cheng, Sammy Kin, Lau, Kwok Kwong, Li, Ho Lun, Yiu Chan, Eric Lok

“…Objective. – To evaluate the effects of disease severity, corticosteroids and social factors on neuropsychiatric complaints in severe acute respiratory…”
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Transcriptomic and metabolic profiling of Tolvaptan treated Autosomal dominant polycystic kidney disease (ADPKD) patient by Lin, Hugo Y., Xu, Frank, Ho, Li‐Lun, Huang, Li‐Ju, Lu, Tzongshi

“…Background Autosomal dominant polycystic kidney disease (ADPKD) is the most common and life‐threatening genetic kidney disease that characterized by the…”
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Vascular smooth muscle-derived Trpv1+ progenitors are a source of cold-induced thermogenic adipocytes by Shamsi, Farnaz, Piper, Mary, Ho, Li-Lun, Huang, Tian Lian, Gupta, Anushka, Streets, Aaron, Lynes, Matthew D., Tseng, Yu-Hua

“…Brown adipose tissue (BAT) and beige fat function in energy expenditure in part due to their role in thermoregulation, making these tissues attractive targets…”
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Use of Direct Thrombin Inhibitor for Treatment of Cerebral Venous Thrombosis by Hon, Sonny Fong Kwong, FHKCP, Li, Ho Lun Terrance, FRCP, Cheng, Pui Wai, FRCR

“…Cerebral venous thrombosis is an uncommon condition with difficulties in diagnosis and treatment. There is limited study on the best treatment option for this…”
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The clinical course of multiple sclerosis patients in Hong Kong by Lau, Kwok-kwong, Wong, Winnie Wing-Yin, Sheng, Bun, Yu, Ignatius Tak-Sun, Fung, Bun-Hey, Li, Ho-Lun, Ma, Ka-Fai Johnny, Wong, Lawrence Ka-Sing, Li, Patrick Chung-Ki

“…Abstract Background Multiple sclerosis (MS) has a low prevalence in Hong Kong. Objective To reassess MS prevalence in Hong Kong and to examine associated risk…”
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The Minimal Structural Domains Required for Neural Cell Adhesion Molecule Polysialylation by PST/ST8Sia IV and STX/ST8Sia II by Close, Brett E., Mendiratta, Shalu Shiv, Geiger, Kristin M., Broom, Lucy J., Ho, Li-Lun, Colley, Karen J.

“…A limited number of mammalian proteins are modified by polysialic acid, with the neural cell adhesion molecule (NCAM) being the most abundant of these. We…”
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Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila by Ho, Li-Lun, Wei, Xiaomu, Shimizu, Takeshi, Lai, Zhi-Chun

“…Growth inhibition mediated by Hippo (Hpo) signaling is essential for tissue growth and organ size control in Drosophila. However, the cellular mechanism by…”
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Coexisting Cerebral Infarction in Alzheimer's Disease Is Associated with Fast Dementia Progression: Applying the National Institute for Neurological Disorders and Stroke/Association Internationale pour la Recherche et l'Enseignement en Neurosciences Neuroimaging Criteria in Alzheimer's Disease with Concomitant Cerebral Infarction by Sheng, Bun, Cheng, Lik Fai, Law, Chun Bon, Li, Ho Lun, Yeung, Kwan Mo, Lau, Kwok Kwong

“…OBJECTIVES: To determine whether patients with Alzheimer's disease (AD) and coexisting cerebral infarction (CI) that satisfy the National Institute for…”
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Low-molecular-weight heparin compared with aspirin for the treatment of acute ischaemic stroke in Asian patients with large artery occlusive disease: a randomised study by Wong, Ka Sing, Prof, Chen, Christopher, FRCP, Ng, Ping Wing, FRCP, Tsoi, Tak Hong, FRCP, Li, Ho Lun, MRCP, Fong, Wing Chi, MRCP, Yeung, Jonas, FRCP, Wong, Chi Keung, FRCP, Yip, Kin Keung, MRCP, Gao, Hong, MD, Wong, Hwee Bee, MSc

“…Summary Background Acute stroke patients with large artery occlusive disease (LAOD) have a distinct pathophysiology and may respond differently to…”
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