Search Results - "Ho, Jonathan Z."

Enantiospecific Synthesis of Carbapentostatins by Ho, Jonathan Z, Mohareb, Rafat M, Ahn, Jin Hee, Sim, Tae Bo, Rapoport, Henry

“…In this paper we describe enantioselective syntheses of (+)-carbapentostatin (8) and its cyclopentyl analogue 12b. A new and efficient one-pot, two-step…”
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Chlorxanthomycin, a Fluorescent, Chlorinated, Pentacyclic Pyrene from a Bacillus sp by MAGYAROSY, Andrew, HO, Jonathan Z, RAPOPORT, Henry, DAWSON, Scott, HANCOCK, Joe, KEASLING, Jay D

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Metabolism and Excretion of Anacetrapib, a Novel Inhibitor of the Cholesteryl Ester Transfer Protein, in Humans by KUMAR, Sanjeev, TAN, Eugene Y, KARANAM, Bindhu, DEAN, Dennis C, GENDRANO, Isaias Noel, GRAVES, Mark W, WAGNER, John A, KRISHNA, Rajesh, HARTMANN, Georgy, BIDDLE, Zachary, BERGMAN, Arthur J, DRU, James, HO, Jonathan Z, JONES, Allen N, STASKIEWICZ, Steve J, BRAUN, Matthew P

“…Anacetrapib is a novel cholesteryl ester transfer protein inhibitor being developed for the treatment of primary hypercholesterolemia and mixed dyslipidemia…”
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An Efficient Procedure for the Preparation of (1S,3R)- and (1S,3S)-1-Amino-3-(hydroxymethyl)cyclopentanes by Rapoport, Henry, Chen, Yuewu, Mohareb, Rafat M., Ahn, Jin Hee, Sim, Tae Bo, Ho, Jonathan Z.

“…Enantiomerically pure (1S,3S)- and (1S,3R)-1-amino-3-(hydroxymethyl)cyclopentanes have been efficiently synthesized from L-aspartic acid. The title compounds…”
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Carbocationic Rearrangements of Silphinane Derivatives by Coates, Robert M, Ho, Jonathan Z, Klobus, Michael, Zhu, Lijuan

“…Solvolysis of silphin-1α and -1β-yl mesylates (18α-OMs and 18β-OMs) gave rise to mixtures of silphinene (4), bridgehead alcohol 22-OH (or its acetate), and…”
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Efficient Synthesis of 14C-Labeled 1H-Pyrazolo[3,4-d]pyrimidine and Related [4.3.0]-Bicyclic Pyrimidino Systems by Ho, Jonathan Z., Van Arsdale, Kyle R., Braun, Matthew P.

“…In support of a research program aimed at discovering purine‐related anticancer drug candidates, a method for the 14C‐labeling of pyrazolopyrimidines utilizing…”
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Pharmacokinetics, Metabolism, and Excretion of Anacetrapib, a Novel Inhibitor of the Cholesteryl Ester Transfer Protein, in Rats and Rhesus Monkeys by TAN, Eugene Y, HARTMANN, Georgy, WEI TANG, KUMAR, Sanjeev, QING CHEN, PEREIRA, Antonio, BRADLEY, Scott, DOSS, George, ZHANG, Andy Shiqiang, HO, Jonathan Z, BRAUN, Matthew P, DEAN, Dennis C

“…The pharmacokinetics and metabolism of anacetrapib (MK-0859), a novel cholesteryl ester transfer protein inhibitor, were examined in rats and rhesus monkeys…”
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An efficient synthesis of carbon-14-labeled 6-[2-(dimethylamino)ethyl]-14-(1-ethylpropyl)-5,6,7,8-tetrahydroindolo [2,1-α] [2,5]benzodiazocine-11-carboxylic acid using Curtius rearrangement reaction as a key step by Zhang, Andy Shiqiang, Ho, Jonathan Z., Braun, Matthew P.

“…Here we report an efficient synthesis of 14C‐labeled…”
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Use of Dibutyl[14C]formamide as a Formylating Reagent in the Vilsmeier-Haack Reaction and Synthesis of a 14C-Labeled Novel Phosphodiesterase-4 (PDE-4) Inhibitor by Ho, Jonathan Z., Elmore, Charles S., Wallace, Michael A., Yao, Dan, Braun, Matthew P., Dean, Dennis C., Melillo, David G., Chen, Cheng-yi

“…A simple, high‐yielding synthesis of dibutyl[14C]formamide ([14C]DBF; 1) from 14CO2 was developed (Scheme 1): reaction of LiBEt3H and 14CO2 followed by aqueous…”
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BIOACTIVATION OF THE 3-AMINO-6-CHLOROPYRAZINONE RING IN A THROMBIN INHIBITOR LEADS TO NOVEL DIHYDRO-IMIDAZOLE AND IMIDAZOLIDINE DERIVATIVES: STRUCTURES AND MECHANISM USING 13C-LABELS, MASS SPECTROMETRY, AND NMR by SUBRAMANIAN, Raju, LIN, Charles C, HO, Jonathan Z, PITZENBERGER, Steven M, SILVA-ELIPE, Maria V, GIBSON, Christopher R, BRAUN, Matthew P, XIAO YU, YERGEY, James L, SINGH, Rominder

“…Thrombin is a serine protease that plays a key role in the blood coagulation cascade. Compound I…”
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Novel, potent non-covalent thrombin inhibitors incorporating P3-lactam scaffolds by HO, Jonathan Z, GIBSON, Tony S, SEMPLE, J. Edward

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Cu(I)Br-mediated preparation of 14C-labeled 3-pyridineacetate derivatives and synthesis of a novel 14C-labeled PDE-IV inhibitor by Ho, Jonathan Z., Braun, Matthew P.

“…An efficient protocol for the synthesis of 14C‐labeled 3‐pyridineacetate (1) and its N‐oxide ([14C]2) is described. Oxidation of this pyridine ([14C]1) to its…”
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Solid-phase synthesis of isotope-labeled 2-propyloctanoic acid, a therapeutic agent for stroke and Alzheimer's disease by Ho, Jonathan Z., Tang, Cheng, Braun, Matthew P.

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Non-covalent thrombin inhibitors featuring P3-Heterocycles with P1-Monocyclic arginine surrogates by REINER, John E, SIEV, Daniel V, GIBSON, Tony S, ANDERSON, Susanne M, BRADBURY, Annette E, NOLAN, Thomas G, SEMPLE, J. Edward, ARALDI, Gian-Luca, CUI, Jingrong Jean, HO, Jonathan Z, KOMANDLA MALLA REDDY, MAMEDOVA, Lala, VU, Phong H, LEE, Kuen-Shan S, MINAMI, Nathaniel K

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Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-bicyclic arginine surrogates by CUI, Jingrong Jean, ARALDI, Gian-Luca, MINAMI, Nathaniel K, ANDERSON, Susanne M, BRADBURY, Annette E, NOLAN, Thomas G, SEMPLE, J. Edward, REINER, John E, KOMANDLA MALLA REDDY, KEMP, Scott J, HO, Jonathan Z, SIEV, Daniel V, MAMEDOVA, Lala, GIBSON, Tony S, GAUDETTE, John A

“…Novel, potent, and highly selective classes of thrombin inhibitors were identified, which resulted from judicious combination of P4-aromatics and…”
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Applications of LC-ARC™ stop-flow radiochemical detection by Schenk, David J., Ho, Jonathan Z., Simeone, Joseph P., Wallace, Michael A., Cato, Brian P., Staskiewicz, Steven J., Jones, Allen N., Melillo, David G.

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Uses of 1-Cyanoacetyl-4-phenyl-3-thiosemicarbazide in Heterocyclic Synthesis: Synthesis of Thiazole, Coumarin, and Pyridine Derivatives with Antimicrobial and Antifungal Activities by Mohareb, Rafat M., Ho, Jonathan Z., Mohamed, Abeer A.

“…The reaction of cyanoacetyl hydrazine with phenylisothiocyanate gave the thiosemicarbazide 3 . The latter underwent a series of heterocyclization reactions…”
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Efficient Synthesis of 14 C‐Labeled 1 H ‐Pyrazolo[3,4‐ d ]pyrimidine and Related [4.3.0]‐Bicyclic Pyrimidino Systems by Ho, Jonathan Z., Van Arsdale, Kyle R., Braun, Matthew P.

“…Abstract In support of a research program aimed at discovering purine‐related anticancer drug candidates, a method for the 14 C‐labeling of pyrazolopyrimidines…”
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Cu(I)Br‐mediated preparation of 14 C‐labeled 3‐pyridineacetate derivatives and synthesis of a novel 14 C‐labeled PDE‐IV inhibitor by Ho, Jonathan Z., Braun, Matthew P.

“…Abstract An efficient protocol for the synthesis of 14 C‐labeled 3‐pyridineacetate ( 1 ) and its N ‐oxide ([ 14 C] 2 ) is described. Oxidation of this pyridine…”
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Synthesis of isotopically labeled 2-pyridinyloxyisobutanoic acid, a building block for CB-1 inhibitors as drug candidates for obesity treatment by Ho, Jonathan Z., Braun, Matthew P.

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