Search Results - "Ho, Jenny M"

Myelodysplastic Neoplasms (MDS) with Ring Sideroblasts or SF3B1 Mutations: The Improved Clinical Utility of World Health Organization and International Consensus Classification 2022 Definitions, a Single-Centre Retrospective Chart Review by Mortuza, Shamim, Chin-Yee, Benjamin, James, Tyler E, Chin-Yee, Ian H, Hedley, Benjamin D, Ho, Jenny M, Saini, Lalit, Lazo-Langner, Alejandro, Schenkel, Laila, Bhai, Pratibha, Sadikovic, Bekim, Keow, Jonathan, Sangle, Nikhil, Hsia, Cyrus C

“…Myelodysplastic neoplasms (MDS) with ring sideroblasts (RS) are diagnosed via bone marrow aspiration in the presence of either (i) ≥15% RS or (ii) 5-14% RS and…”
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CD200 expression marks leukemia stem cells in human AML by Ho, Jenny M., Dobson, Stephanie M., Voisin, Veronique, McLeod, Jessica, Kennedy, James A., Mitchell, Amanda, Jin, Liqing, Eppert, Kolja, Bader, Gary, Minden, Mark D., Dick, John E., Wang, Jean C.Y.

“…The leukemia stem cell (LSC) populations of acute myeloid leukemia (AML) exhibit phenotypic, genetic, and functional heterogeneity that contribute to therapy…”
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Antidepressant efficacy of low-frequency repetitive transcranial magnetic stimulation in antidepressant-nonresponding bipolar depression: a single-blind randomized sham-controlled trial by Mak, Arthur D. P., Neggers, Sebastiaan F. W., Leung, Owen N. W., Chu, Winnie C. W., Ho, Jenny Y. M., Chou, Idy W. Y., Chan, Sandra S. M., Lam, Linda C. W., Lee, Sing

“…Background To examine the antidepressant efficacy and response predictors of R-DLPFC-LF rTMS for antidepressant-nonresponding BD. Methods We conducted a…”
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Clinical Features and Long-Term Outcomes of a Pan-Canadian Cohort of Adolescents and Young Adults with Myeloproliferative Neoplasms: A Canadian MPN Group Study by England, James T., Szuber, Natasha, Sirhan, Shireen, Dunne, Tom, Cerquozzi, Sonia, Hill, Madeleine, Villeneuve, Pierre J. A., Ho, Jenny M., Sadikovic, Bekim, Bhai, Pratibha, Krishnan, Nupur, Dowhanik, Sebastian, Hillis, Chris, Capo-Chichi, Jose-Mario, Tsui, Hubert, Cheung, Verna, Gauthier, Karine, Sibai, Hassan, Davidson, Marta B., Bankar, Aniket, Kotchetkov, Rouslan, Gupta, Vikas, Maze, Dawn

“…Myeloproliferative neoplasms (MPNs) are a group of chronic hematologic malignancies that lead to morbidity and early mortality due to thrombotic complications…”
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A Rational Approach to JAK2 Mutation Testing in Patients with Elevated Hemoglobin: Results from the JAK2 Prediction Cohort (JAKPOT) Study by Chin-Yee, Benjamin, Bhai, Pratibha, Cheong, Ian, Matyashin, Maxim, Hsia, Cyrus C., Kawata, Eri, Ho, Jenny M., Levy, Michael A., Stuart, Alan, Lin, Hanxin, Chin-Yee, Ian, Kadour, Mike, Sadikovic, Bekim, Lazo-Langner, Alejandro

“…Background Erythrocytosis, most often measured as an increase in hemoglobin and/or hematocrit, is a common reason for referral to internal medicine and…”
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CD47-SIRPα Interactions Regulate Macrophage Uptake of Plasmodium falciparum-Infected Erythrocytes and Clearance of Malaria In Vivo by Ayi, Kodjo, Lu, Ziyue, Serghides, Lena, Ho, Jenny M, Finney, Constance, Wang, Jean C Y, Liles, W Conrad, Kain, Kevin C

“…CD47 engagement by the macrophage signal regulatory protein alpha (SIRPα) inhibits phagocytic activity and protects red blood cells (RBCs) from…”
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Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts by Theocharides, Alexandre P A, Jin, Liqing, Cheng, Po-Yan, Prasolava, Tatiana K, Malko, Andrei V, Ho, Jenny M, Poeppl, Armando G, van Rooijen, Nico, Minden, Mark D, Danska, Jayne S, Dick, John E, Wang, Jean C Y

“…Although tumor surveillance by T and B lymphocytes is well studied, the role of innate immune cells, in particular macrophages, is less clear. Moreover, the…”
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Emerging therapies for acute myeloid leukemia: translating biology into the clinic by Kavanagh, Simon, Murphy, Tracy, Law, Arjun, Yehudai, Dana, Ho, Jenny M, Chan, Steve, Schimmer, Aaron D

“…Acute myeloid leukemia (AML) is an aggressive hematological malignancy with a poor outcome; overall survival is approximately 35% at two years and some…”
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TEL-JAK2 constitutively activates the extracellular signal–regulated kinase (ERK), stress-activated protein/Jun kinase (SAPK/JNK), and p38 signaling pathways by Ho, Jenny M.-Y., Nguyen, Melody H.-H., Dierov, Jamil K., Badger, Karla M., Beattie, Bryan K., Tartaro, Piero, Haq, Rizwan, Zanke, Brent W., Carroll, Martin P., Barber, Dwayne L.

“…The ets transcription factor, TEL, undergoes chromosomal rearrangements with the tyrosine kinase JAK2. TEL-JAK2 is constitutively active, confers cell line…”
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Targeting SIRPα in cancer by Ho, Jenny M., Danska, Jayne S., Wang, Jean C.Y.

“…Strategies to harness the patient's immune system to fight cancer have mainly involved adoptive T-cell transfer. We and others have recently highlighted an…”
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Rivaroxaban for Improvement in Thromboembolism Outcomes in Patients with Multiple Myeloma on Lenalidomide-Based Therapy: The Rithmm Feasibility Pilot Trial by Louzada, Martha L, McCurdy, Arleigh, Shivakumar, Sudeep P, Quint, Anthony, Salib, Mary, Lazo-Langner, Alejandro, Phua, Chai Wye, Le Gal, Gregoire, Lam, Selay, Ho, Jenny M.

“…Introduction:The association between thrombosis (TE) and cancer has been well established. The risk for thrombosis in Multiple Myeloma (MM) is further…”
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Clinical Features and Mutational Landscape of Patients Referred for Suspected Essential Thrombocytosis: A Descriptive Study Using a 'Real-World’ Database by Almanaseer, Ala, Chin-Yee, Benjamin, Bhai, Pratibha, Cheong, Ian, Lazo-Langner, Alejandro, Ho, Jenny M., Levy, Michael A., Stuart, Alan, Lin, Hanxin, Chin-Yee, Ian, Sadikovic, Bekim, Hsia, Cyrus C.

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Stem Cell-Derived Gene Expression Scores Predict Survival and Leukemic Transformation in Myelofibrosis by Medeiros, Jessie J.F., Zeng, Andy G.X., Chan-Seng-Yue, Michelle, Woo, Tristan, McLeod, Jessica L, Arruda, Andrea, Tsui, Hubert, Goraya, Burhan, Claudio, Jaime O., Ho, Jenny M., Kennedy, James A., Maze, Dawn, Sibai, Hassan, Minden, Mark D., Wang, Jean C.Y., Dick, John E., Gupta, Vikas

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Myelodysplastic Neoplasms with Ring Sideroblasts or ISF3B1/I Mutations: The Improved Clinical Utility of World Health Organization and International Consensus Classification 2022 Definitions, a Single-Centre Retrospective Chart Review by Mortuza, Shamim, Chin-Yee, Benjamin, James, Tyler E, Chin-Yee, Ian H, Hedley, Benjamin D, Ho, Jenny M, Saini, Lalit, Lazo-Langner, Alejandro, Schenkel, Laila, Bhai, Pratibha, Sadikovic, Bekim, Keow, Jonathan, Sangle, Nikhil, Hsia, Cyrus C

“…Myelodysplastic neoplasms (MDS) with ring sideroblasts (RS) are diagnosed via bone marrow aspiration in the presence of either (i) ≥15% RS or (ii) 5–14% RS and…”
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Myelofibrosis Is Initiated and Sustained By Rare Multipotent Stem Cells by Medeiros, Jessie J.F., Mitchell, Amanda, Trotman-Grant, Aaron, Woo, Tristan, Ho, Jenny M., Arruda, Andrea, Minden, Mark D., Dick, John E., Gupta, Vikas, Shlush, Liran I.

“…Background: Myelofibrosis (MF) is a chronic myeloproliferative neoplasm (MPN) characterized by marked bone marrow fibrosis, extramedullary hematopoiesis and…”
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HSCs Fated to Progress to Blast Phase Can be Detected in Myelofibrosis Patients Several Years Prior to Leukemic Transformation by Ho, Jenny M., Medeiros, Jessie J.F., Chan-Seng-Yue, Michelle, Hummel, Lauren, Arruda, Andrea, Mitchell, Amanda, McNamara, Caroline J, Kennedy, James A, Tierens, Anne, Maze, Dawn, Tsui, Hubert, Minden, Mark D., Gupta, Vikas, Dick, John E.

“…In myeloproliferative neoplasms (MPN), somatic mutations in genes recurrently mutated in myeloid leukemia, apart from known MPN driver mutations (JAK2, MPL,…”
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AML-Fated Clones Arise in Stem and Progenitor Cells in Myelofibrosis Patients Several Years Prior to AML Diagnosis by Ho, Jenny M., Medeiros, Jessie James Franco, Chan-Seng-Yue, Michelle, Hummel, Lauren, Arruda, Andrea, Mitchell, Amanda, McNamara, Caroline J, Kennedy, James, Tierens, Anne, Tsui, Hubert, Minden, Mark D., Gupta, Vikas, Dick, John E.

“…In myeloproliferative neoplasms (MPN), somatic mutations in recurrently mutated myeloid leukemia genes, apart from MPN driver genes, are common and can…”
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Isolation of CD34− and CD34+ Leukemia Stem Cells from Acute Myeloid Leukemia Blasts Using CD200 by Ho, Jenny M., Dobson, Stephanie M., McLeod, Jessica, Voisin, Veronique, Murison, Alex, Kennedy, James, Zandi, Sasan, Eppert, Kolja, Minden, Mark D., Lupien, Mathieu, Dick, John E., Wang, Jean C.Y.

“…Therapy resistance and relapse in acute myeloid leukemia (AML) are driven by leukemia stem cells (LSCs). Recent evidence highlighting functional and genetic…”
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CD200 Is a Marker of LSC Activity in Acute Myeloid Leukemia by Ho, Jenny M., Dobson, Stephanie M., McLeod, Jessica, Jin, Liqing, Ng, Stanley W.K., Mitchell, Amanda, Shlush, Liran I., Zandi, Sasan, Eppert, Kolja, Minden, Mark D., Dick, John E., Wang, Jean C.Y.

“…Acute myeloid leukemia (AML) is a hierarchical disease in which the bulk blast population is sustained by a minority population of leukemia stem cells (LSC)…”
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Impact of Genomic Alterations on Outcomes in Myelofibrosis Patients Undergoing JAK1/2 Inhibitor Therapy by Spiegel, Jay, McNamara, Caroline Jane, Arruda, Andrea, Panzarella, Tony, Kennedy, James A., Stockley, Tracy L., Sukhai, Mahadeo, Thomas, Mariam, Bartoszko, Justyna, Ho, Jenny M., Siddiq, Nancy, Schimmer, Aaron D., Schuh, Andre C., Sibai, Hassan, Yee, Karen W.L., Claudio, Jaime O., Devlin, Rebecca, Minden, Mark D., Kamel-Reid, Suzanne, Gupta, Vikas

“…Introduction: The advent of next generation sequencing (NGS) has brought intense interest to the complex genetic landscape of myeloproliferative neoplasms…”
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