Search Results - "Ho, Ivy A"

Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasiveness by Fadhlullah, Siti Farah Bte, Halim, Nurashikin Bte Abdul, Yeo, Jacqueline Y. T., Ho, Rachel L. Y., Um, Phoebe, Ang, Beng Ti, Tang, Carol, Ng, Wai H., Virshup, David M., Ho, Ivy A. W.

“…Glioblastoma (GBM) is the most aggressive tumor of the brain. NF1 , a tumor suppressor gene and RAS-GTPase, is one of the highly mutated genes in GBM…”
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Human Bone Marrow‐Derived Mesenchymal Stem Cells Suppress Human Glioma Growth Through Inhibition of Angiogenesis by Ho, Ivy A.W., Toh, Han C, Ng, Wai H., Teo, Yuan L., Guo, Chang M., Hui, Kam M., Lam, Paula Y.P.

“…Tumor tropism of human bone marrow‐derived mesenchymal stem cells (MSC) has been exploited for the delivery of therapeutic genes for anticancer therapy…”
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Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme by Newman, Jennifer P., Wang, Grace Y., Arima, Kazuhiko, Guan, Shou P., Waters, Michael R., Cavenee, Webster K., Pan, Edward, Aliwarga, Edita, Chong, Siao T., Kok, Catherine Y. L., Endaya, Berwini B., Habib, Amyn A., Horibe, Tomohisa, Ng, Wai H., Ho, Ivy A. W., Hui, Kam M., Kordula, Tomasz, Lam, Paula Y. P.

“…The interleukin-13 receptor alpha2 (IL-13Rα2) is a cancer-associated receptor overexpressed in human glioblastoma multiforme (GBM). This receptor is…”
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Contribution of the Microenvironmental Niche to Glioblastoma Heterogeneity by Ho, Ivy A. W., Shim, Winston

“…Glioblastoma is the most aggressive cancer of the brain. The dismal prognosis is largely attributed to the heterogeneous nature of the tumor, which in addition…”
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Combined treatment of Nimotuzumab and rapamycin is effective against temozolomide-resistant human gliomas regardless of the EGFR mutation status by Chong, Dawn Q, Toh, Xin Y, Ho, Ivy A W, Sia, Kian C, Newman, Jennifer P, Yulyana, Yulyana, Ng, Wai-Hoe, Lai, Siang H, Ho, Mac M F, Dinesh, Nivedh, Tham, Chee K, Lam, Paula Y P

“…The treatment of glioblastoma multiforme (GBM) is an unmet clinical need. The 5-year survival rate of patients with GBM is less than 3%. Temozolomide (TMZ)…”
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Paracrine Factors of Human Fetal MSCs Inhibit Liver Cancer Growth Through Reduced Activation of IGF-1R/PI3K/Akt Signaling by Yulyana, Yulyana, Ho, Ivy A W, Sia, Kian Chuan, Newman, Jennifer P, Toh, Xin Yi, Endaya, Berwini B, Chan, Jerry K Y, Gnecchi, Massimiliano, Huynh, Hung, Chung, Alexander Y F, Lim, Kiat Hon, Leong, Hui Sun, Iyer, Narayanan Gopalakrishna, Hui, Kam Man, Lam, Paula Y P

“…Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death in the world. The multikinase inhibitor sorafenib only demonstrated marginal…”
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Matrix Metalloproteinase 1 Is Necessary for the Migration of Human Bone Marrow‐Derived Mesenchymal Stem Cells Toward Human Glioma by Ho, Ivy A. W., Chan, Kelly Y. W., Ng, Wai‐Hoe, Guo, Chang M., Hui, Kam M., Cheang, Philip, Lam, Paula Y. P.

“…Human mesenchymal stem cells (MSCs) have increasingly been used as cellular vectors for the delivery of therapeutic genes to tumors. However, the precise…”
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Matrix metalloproteinase‐1‐mediated mesenchymal stem cell tumor tropism is dependent on crosstalk with stromal derived growth factor 1/C‐X‐C chemokine receptor 4 axis by Ho, Ivy A. W., Yulyana, Yulyana, Sia, Kian C., Newman, Jennifer P., Guo, Chang M., Hui, Kam M., Lam, Paula Y. P.

“…Human bone marrow‐derived mesenchymal stem cells (MSCs) have the unique ability to home toward injuries or tumor sites. We have previously shown that the…”
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Angiopoietin: A TIE(d) Balance in Tumor Angiogenesis by Shim, Winston S N, Ho, Ivy A W, Wong, Philip E H

“…Angiopoietins (ANG-1 and ANG-2) and their TIE-2 receptor tyrosine kinase have wide-ranging effects on tumor malignancy that includes angiogenesis,…”
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FasL and FADD delivery by a glioma-specific and cell cycle-dependent HSV-1 amplicon virus enhanced apoptosis in primary human brain tumors by Ho, Ivy A, Ng, Wai H, Lam, Paula Y

“…Glioblastoma multiforme is the most malignant cancer of the brain and is notoriously difficult to treat due to the highly proliferative and infiltrative nature…”
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Isolation of peptide ligands that interact specifically with human glioma cells by Ho, Ivy A.W., Hui, Kam M., Lam, Paula Y.P.

“…Poor prognosis of high grade gliomas coupled with the difficulty of widespread delivery of therapeutic agents prompted the search into new molecular targets…”
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Recent Advances in Glioma Therapy: Combining Vascular Normalization and Immune Checkpoint Blockade by Ho, Rachel L. Y., Ho, Ivy A. W.

“…Glioblastoma (GBM) accounts for more than 50% of all primary malignancies of the brain. Current standard treatment regimen for GBM includes maximal surgical…”
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Hybrid herpes simplex virus/Epstein-Barr virus amplicon viral vectors confer enhanced transgene expression in primary human tumors and human bone marrow-derived mesenchymal stem cells by Sia, Kian Chuan, Chong, Wei Kin, Ho, Ivy A. W., Yulyana, Yulyana, Endaya, Berwini, Huynh, Hung, Lam, Paula Y. P.

“…Background Herpes simplex virus type‐1 (HSV‐1) amplicon vectors are attractive tools for gene transfer because of their large DNA insert capacity, their broad…”
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Carbenoxolone enhances TRAIL-induced apoptosis through the upregulation of death receptor 5 and inhibition of gap junction intercellular communication in human glioma by Yulyana, Yulyana, Endaya, Berwini B, Ng, Wai H, Guo, Chang M, Hui, Kam M, Lam, Paula Y P, Ho, Ivy A W

“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been used extensively in cancer therapy. However, more than half of glioblastoma multiforme…”
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Signaling molecules and pathways involved in MSC tumor tropism by Ho, Ivy A W, Lam, Paula Y P

“…Human bone marrow is a reservoir containing cells with different self-renewal capabilities, such as mesenchymal stem cells (MSC) and hematopoeitic stem cells…”
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Engineering an improved cell cycle-regulatable herpes simplex virus type 1 amplicon vector with enhanced transgene expression in proliferating cells yet attenuated activities in resting cells by Wang, Grace Y, Ho, Ivy A W, Sia, Kian C, Miao, L, Hui, Kam M, Lam, Paula Y P

“…We previously generated a herpes simplex virus type 1 (HSV-1)-based amplicon vector (denoted pC8-36) in which gene expression from the minimal cyclin A…”
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Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP5+, Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme by Yulyana, Yulyana, Tovmasyan, Artak, Ho, Ivy AW, Sia, Kian Chuan, Newman, Jennifer P, Ng, Wai Hoe, Guo, Chang Ming, Hui, Kam Man, Batinic-Haberle, Ines, Lam, Paula YP

“…Glioblastoma multiforme is the most malignant tumor of the brain and is challenging to treat due to its highly invasive nature and heterogeneity. Malignant…”
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Optimal purification method for Herpes-based viral vectors that confers minimal cytotoxicity for systemic route of vector administration by Sia, Kian Chuan, Wang, Grace Y., Ho, Ivy A.W., Khor, Hong Yuan, Miao, Lv, Hui, Kam M., Lam, Paula Y.P.

“…Herpes simplex virus (HSV)-1 amplicon vectors could be packaged in the presence of replication-competent helper virus or in a helper virus-free system. In the…”
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An Efficient and Safe Herpes Simplex Virus Type 1 Amplicon Vector for Transcriptionally Targeted Therapy of Human Hepatocellular Carcinomas by Lam, Paula YP, Sia, Kian Chuan, Khong, Jenn H, Geest, Bart De, Lim, Kar S, Ho, Ivy AW, Wang, Grace Y, Miao, Lv, Huynh, H, Hui, Kam M

“…Our previous studies have shown that transgene expression could be targeted to proliferating cells when cell cycle transcriptional regulatory elements were…”
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Glioma-specific and cell cycle-regulated herpes simplex virus type 1 amplicon viral vector by Ho, Ivy A W, Hui, Kam M, Lam, Paula Y P

“…We have engineered a novel herpes simplex virus type 1 (HSV-1)-based amplicon viral vector, whereby gene expression is controlled by cell cycle events. In…”
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