Search Results - "Ho, Dong Hwan"

LRRK2 Inhibition Mitigates the Neuroinflammation Caused by TLR2-Specific α-Synuclein and Alleviates Neuroinflammation-Derived Dopaminergic Neuronal Loss by Ho, Dong-Hwan, Nam, Daleum, Seo, Mikyoung, Park, Sung-Woo, Seol, Wongi, Son, Ilhong

“…Evidence suggests that crosstalk occurs between microglial leucine-rich repeat kinase 2 (LRRK2)-a regulator of neuroinflammation-and neuron-released…”
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An early endosome regulator, Rab5b, is an LRRK2 kinase substrate by Yun, Hye Jin, Kim, Hyejung, Ga, Inhwa, Oh, Hakjin, Ho, Dong Hwan, Kim, Jiyoung, Seo, Hyemyung, Son, Ilhong, Seol, Wongi

“…Leucine-rich repeat kinase 2 (LRRK2) has been identified as a causative gene for Parkinson's disease (PD). LRRK2 contains a kinase and a GTPase domain, both of…”
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Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers by Lee, He-Jin, Baek, Sung Min, Ho, Dong-Hwan, Suk, Ji-Eun, Cho, Eun-Duk, Lee, Seung-Jae

“…Parkinson's disease (PD) is characterized by selective and progressive degeneration of dopamine (DA)-producing neurons in the substantia nigra pars compacta…”
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Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia by Kim, Changyoun, Ho, Dong-Hwan, Suk, Ji-Eun, You, Sungyong, Michael, Sarah, Kang, Junghee, Joong Lee, Sung, Masliah, Eliezer, Hwang, Daehee, Lee, He-Jin, Lee, Seung-Jae

“…Abnormal aggregation of α-synuclein and sustained microglial activation are important contributors to the pathogenic processes of Parkinson’s disease. However,…”
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Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission by Bae, Eun-Jin, Lee, He-Jin, Rockenstein, Edward, Ho, Dong-Hwan, Park, Eun-Bi, Yang, Na-Young, Desplats, Paula, Masliah, Eliezer, Lee, Seung-Jae

“…Abnormal deposition and intercellular propagation of α-synuclein plays a central role in the pathogenesis of disorders such as Parkinson's Disease (PD) and…”
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Dexamethasone induces the expression of LRRK2 and α-synuclein, two genes that when mutated cause Parkinson's disease in an autosomal dominant manner by Park, Ji-Min, Ho, Dong-Hwan, Yun, Hye Jin, Kim, Hye-Jung, Lee, Chan Hong, Park, Sung Woo, Kim, Young Hoon, Son, Ilhong, Seol, Wongi

“…LRRK2 (leucine-rich repeat kinase 2) has been identified as a gene corresponding to PARK8, an autosomal-dominant gene for familial Parkinson's disease (PD)…”
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Nuclear α-Synuclein-Derived Cytotoxic Effect via Altered Ribosomal RNA Processing in Primary Mouse Embryonic Fibroblasts by Ho, Dong Hwan, Kim, Hyejung, Nam, Daleum, Heo, Jinju, Son, Ilhong

“…α-Synuclein (αSyn) is an important player in Parkinson's disease (PD) pathogenesis. The aggregation of αSyn is mainly formed in the cytoplasm, whereas some…”
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Lipid peroxidation product 4-hydroxy-2-nonenal promotes seeding-capable oligomer formation and cell-to-cell transfer of α-synuclein by Bae, Eun-Jin, Ho, Dong-Hwan, Park, Eunbi, Jung, Jin Woo, Cho, Kyungcho, Hong, Ji Hye, Lee, He-Jin, Kim, Kwang Pyo, Lee, Seung-Jae

“…Abnormal accumulation of α-synuclein aggregates is one of the key pathological features of many neurodegenerative movement disorders and dementias. These…”
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Expression of transduced nucleolin promotes the clearance of accumulated α-synuclein in rodent cells and animal model by Ho, Dong Hwan, Nam, Daleum, Jeong, Soyeon, Seo, Mi Kyoung, Park, Sung Woo, Seol, Wongi, Son, Ilhong

“…Alpha-synuclein (αSyn) is a major component of Lewy bodies, which are a known pathogenic marker of Parkinson's disease (PD). The dysfunction of protein…”
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Expression of G2019S LRRK2 in Rat Primary Astrocytes Mediates Neurotoxicity and Alters the Dopamine Synthesis Pathway in N27 Cells via Astrocytic Proinflammatory Cytokines and Neurotrophic Factors by Ho, Dong Hwan, Kim, Hyejung, Nam, Daleum, Seo, Mi Kyoung, Park, Sung Woo, Son, Ilhong

“…Astrocytes in the brain contribute to various essential functions, including maintenance of the neuronal framework, survival, communication, metabolic…”
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Therapeutic Effect of Padina arborescens Extract on a Cell System Model for Parkinson's Disease by Ho, Dong Hwan, Kim, Hyejung, Nam, Daleum, Seo, Mi Kyoung, Park, Sung Woo, Kim, Dong-Kyu, Son, Ilhong

“…Leucine-rich repeat kinase 2 (LRRK2) and α-synuclein are involved in the pathogenesis of Parkinson's disease. The activity of LRRK2 in microglial cells is…”
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G2385R and I2020T Mutations Increase LRRK2 GTPase Activity by Seo, Hyemyung, Son, Ilhong, Joe, Eun-hye, Jang, Jihoon, Ho, Dong Hwan, Seol, Wongi

“…The LRRK2 mutation is a major causal mutation in familial Parkinson’s disease. Although LRRK2 contains functional GTPase and kinase domains and their…”
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G2019s LRRK2 promotes mitochondrial fission and increases TNFα-mediated neuroinflammation responses by Ho, Dong Hwan, Lee, Heajin, Son, Ilhong, Seol, Wongi

“…Leucine rich-repeat kinase 2 (LRRK2) is involved in the pathogenesis of Parkinson's disease (PD). LRRK2 has kinase and GTPase activities, and mediates several…”
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Oxidized DJ-1 Levels in Urine Samples as a Putative Biomarker for Parkinson’s Disease by Ho, Dong Hwan, Seo, Hyemyung, Seol, Wongi, Lee, Sung Ik, Jeong, Soyeon, Jang, Jihoon, Son, Ilhong

“…Parkinson’s disease (PD) is the second most common neurodegenerative disease. Oxidative stress is the most critical risk factor for neurodegenerative diseases,…”
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Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers by Lee, He-Jin, Baek, Sung-Min, Ho, Dong-Hwan, Suk, Ji-Eun, Cho, Eun-Duk, Lee, Seung-Jae

“…Parkinson's disease (PD) is characterized by selective and progressive degeneration of dopamine (DA)-producing neurons in the substantia nigra pars compacta…”
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Dexamethasone induces the expression of LRRK2 and α-synuclein, two genes that when mutated cause Parkinson`s disease in an autosomal dominant manner by Park, Ji-Min, Ho, Dong-Hwan, Yun, Hye Jin, Kim, Hye-Jung, Lee, Chan Hong, Park, Sung Woo, Kim, Young Hoon, Son, Ilhong, Seol, Wongi

“…LRRK2 (leucine-rich repeat kinase 2) has been identified as a gene corresponding to PARK8, an autosomal-dominant gene for familial Parkinson`s disease (PD)…”
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Analysis of α-synuclein levels related to LRRK2 kinase activity: from substantia nigra to urine of patients with Parkinson's disease by Nam, Daleum, Kim, Ami, Han, Sun Jung, Lee, Sung-Ik, Park, Sung-Hye, Seol, Wongi, Son, Ilhong, Ho, Dong Hwan

“…Research on Parkinson's disease (PD) has been focused on the development of PD diagnostic tools as much as the development of PD therapeutics. Several genetic…”
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Increase in anti-apoptotic molecules, nucleolin, and heat shock protein 70, against upregulated LRRK2 kinase activity by Jang, Jihoon, Oh, Hakjin, Nam, Daleum, Seol, Wongi, Seo, Mi Kyoung, Park, Sung Woo, Kim, Hyung Gun, Seo, Hyemyung, Son, Ilhong, Ho, Dong Hwan

“…Leucine-rich repeat kinase 2 (LRRK2) is involved in Parkinson's disease (PD) pathology. A previous study showed that rotenone treatment induced apoptosis,…”
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Correction to: Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression by Ho, Dong Hwan, Kim, Hyejung, Kim, Jisun, Sim, Hyuna, Ahn, Hyunjun, Kim, Janghwan, Seo, Hyemyung, Chung, Kwang Chul, Park, Bum-Joon, Son, Ilhong, Seol, Wongi

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Enzyme-linked immunosorbent assays for alpha-synuclein with species and multimeric state specificities by Lee, He-Jin, Bae, Eun-Jin, Jang, Ara, Ho, Dong-Hwan, Cho, Eun-Duk, Suk, Ji-Eun, Yun, Yeo-Min, Lee, Seung-Jae

“…► Development of ELISA system to detect human alpha-synuclein specifically. ► Development of ELISA system to detect total alpha-synuclein regardless of…”
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