Search Results - "Ho, Carmence"

Antitumor Activity of a Novel LAIR1 Antagonist in Combination with Anti-PD1 to Treat Collagen-Rich Solid Tumors by Rodriguez, Bertha L, Huang, Jiawei, Gibson, Laura, Fradette, Jared J, Chen, Hung-I H, Koyano, Kikuye, Cortez, Czrina, Li, Betty, Ho, Carmence, Ashique, Amir M, Lin, Vicky Y, Crawley, Suzanne, Roda, Julie M, Chen, Peirong, Fan, Bin, Kim, Jeong, Sissons, James, Sitrin, Jonathan, Kaplan, Daniel D, Gibbons, Don L, Rivera, Lee B

“…We recently reported that resistance to PD-1 blockade in a refractory lung cancer-derived model involved increased collagen deposition and the collagen-binding…”
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Abstract LB156: Preclinical evaluation of NGM707, a novel anti-ILT2/anti-ILT4 dual antagonist monoclonal antibody by Mondal, Kalyani, Song, Christina, Tian, Jane, Ho, Carmence, Rivera, Lee B., Huang, Jiawei, Chen, Peirong, Crawley, Suzanne, Lin, Vicky Y., Sitrin, Jonathan, Roda, Julie M., Shen, David, Tian, Hui, Wang, Yan, Kutach, Alan, Kim, Jeong, Sissons, James, Kaplan, Daniel D., Stone, Geoffrey W.

“…Background: Myeloid immune suppression in the tumor microenvironment is known to contribute to tumor immune evasion. ILT2 (aka LILRB1) and ILT4 (aka LILRB2)…”
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ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms by Tian, Jane, Ashique, Amir M, Weeks, Sabrina, Lan, Tian, Yang, Hong, Chen, Hung-I Harry, Song, Christina, Koyano, Kikuye, Mondal, Kalyani, Tsai, Daniel, Cheung, Isla, Moshrefi, Mehrdad, Kekatpure, Avantika, Fan, Bin, Li, Betty, Qurashi, Samir, Rocha, Lauren, Aguayo, Jonathan, Rodgers, Col, Meza, Marchelle, Heeke, Darren, Medfisch, Sara M, Chu, Chun, Starck, Shelley, Basak, Nandini Pal, Sankaran, Satish, Malhotra, Mohit, Crawley, Suzanne, Tran, Thomas-Toan, Duey, Dana Y, Ho, Carmence, Mikaelian, Igor, Liu, Wenhui, Rivera, Lee B, Huang, Jiawei, Paavola, Kevin J, O'Hollaren, Kyle, Blum, Lisa K, Lin, Vicky Y, Chen, Peirong, Iyer, Anjushree, He, Sisi, Roda, Julie M, Wang, Yan, Sissons, James, Kutach, Alan K, Kaplan, Daniel D, Stone, Geoffrey W

“…Solid tumors are dense three-dimensional (3D) multicellular structures that enable efficient receptor-ligand trans interactions via close cell-cell contact…”
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Abstract LB219: Preclinical development of NGM438, a novel anti-LAIR1 antagonist monoclonal antibody for the treatment of collagen-rich solid tumors by He, Sisi, Huang, Jiawei, Rodriguez, Leticia, Cortez, Czrina, Li, Betty, Ho, Carmence, Ashique, Amir, Mondal, Kalyani, Lin, Vicky, Roda, Julie, Tian, Hui, Wang, Yan, Fan, Bin, Mikaelian, Igor, Sissons, James, Rivera, Lee, Gibbons, Don, Sitrin, Jonathan

“…Background: Collagen is an abundant component of the extracellular matrix-enriched stromal microenvironment of solid cancers. Emerging research suggests that…”
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Abstract 664: Immune inhibitory receptors ILT2 and ILT4 exhibit both distinct and overlapping biology in vitro and in vivo by Tian, Jane, Qurashi, Samir, Song, Christina, Rocha, Lauren, Mondal, Kalyani, Crawley, Suzanne, Medfisch, Sara, Chen, Peirong Krisney, Roda, Julie, Sitrin, Jon, Ho, Carmence, Aguayo, Jonathan, Rivera, Lee, Huang, Jiawei, Lin, Vicky, Shen, David, Wang, Yan, Tian, Hui, Kutach, Alan, Sissons, James, Kaplan, Daniel D., Stone, Geoffrey W.

“…Background: Immune suppression in the tumor microenvironment is known to contribute to tumor immune evasion. ILT2 (aka LILRB1) and ILT4 (aka LILRB2) are…”
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