Search Results - "Ho, Beatrice Xuan"

Disease Modeling Using 3D Organoids Derived from Human Induced Pluripotent Stem Cells by Ho, Beatrice Xuan, Pek, Nicole Min Qian, Soh, Boon-Seng

“…The rising interest in human induced pluripotent stem cell (hiPSC)-derived organoid culture has stemmed from the manipulation of various combinations of…”
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Mending a broken heart: current strategies and limitations of cell-based therapy by Liew, Lee Chuen, Ho, Beatrice Xuan, Soh, Boon-Seng

“…The versatility of pluripotent stem cells, attributable to their unlimited self-renewal capacity and plasticity, has sparked a considerable interest for…”
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In Vivo Genome Editing as a Therapeutic Approach by Ho, Beatrice Xuan, Loh, Sharon Jia Hui, Chan, Woon Khiong, Soh, Boon Seng

“…Genome editing has been well established as a genome engineering tool that enables researchers to establish causal linkages between genetic mutation and…”
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Innovations in bio-engineering and cell-based approaches to address immunological challenges in islet transplantation by Ho, Beatrice Xuan, Teo, Adrian Kee Keong, Ng, Natasha Hui Jin

“…Human allogeneic pancreatic islet transplantation is a life-changing treatment for patients with severe Type 1 Diabetes (T1D) who suffer from hypoglycemia…”
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Wnt/β-catenin-mediated signaling re-activates proliferation of matured cardiomyocytes by Fan, Yong, Ho, Beatrice Xuan, Pang, Jeremy Kah Sheng, Pek, Nicole Min Qian, Hor, Jin Hui, Ng, Shi-Yan, Soh, Boon-Seng

“…The Wnt/β-catenin signaling pathway plays an important role in the development of second heart field (SHF Isl1+) that gives rise to the anterior heart field…”
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Robust generation of human-chambered cardiac organoids from pluripotent stem cells for improved modelling of cardiovascular diseases by Ho, Beatrice Xuan, Pang, Jeremy Kah Sheng, Chen, Ying, Loh, Yuin-Han, An, Omer, Yang, Henry He, Seshachalam, Veerabrahma Pratap, Koh, Judice L Y, Chan, Woon-Khiong, Ng, Shi Yan, Soh, Boon Seng

“…Tissue organoids generated from human pluripotent stem cells are valuable tools for disease modelling and to understand developmental processes. While recent…”
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Mitochondrial 3243A > G mutation confers pro-atherogenic and pro-inflammatory properties in MELAS iPS derived endothelial cells by Pek, Nicole Min Qian, Phua, Qian Hua, Ho, Beatrice Xuan, Pang, Jeremy Kah Sheng, Hor, Jin-Hui, An, Omer, Yang, Henry He, Yu, Yang, Fan, Yong, Ng, Shi-Yan, Soh, Boon-Seng

“…Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a mitochondrial disorder that is commonly caused by the m.3243A…”
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JAK2 as a surface marker for enrichment of human pluripotent stem cells-derived ventricular cardiomyocytes by Liew, Lee Chuen, Poh, Boon Min, An, Omer, Ho, Beatrice Xuan, Lim, Christina Ying Yan, Pang, Jeremy Kah Sheng, Beh, Leslie Y, Yang, Henry He, Soh, Boon-Seng

“…Human pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) hold great promise for cardiac disease modelling, drug discovery and regenerative medicine…”
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Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids by Pang, Jeremy Kah Sheng, Ho, Beatrice Xuan, Chan, Woon-Khiong, Soh, Boon-Seng

“…Medical research in the recent years has achieved significant progress due to the increasing prominence of organoid technology. Various developed tissue…”
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ALS motor neurons exhibit hallmark metabolic defects that are rescued by SIRT3 activation by Hor, Jin-Hui, Santosa, Munirah Mohamad, Lim, Valerie Jing Wen, Ho, Beatrice Xuan, Taylor, Amy, Khong, Zi Jian, Ravits, John, Fan, Yong, Liou, Yih-Cherng, Soh, Boon-Seng, Ng, Shi-Yan

“…Motor neurons (MNs) are highly energetic cells and recent studies suggest that altered energy metabolism precede MN loss in amyotrophic lateral sclerosis…”
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Compressible Hollow Microlasers in Organoids for High-Throughput and Real-Time Mechanical Screening by Fang, Guocheng, Ho, Beatrice Xuan, Xu, Hongmei, Gong, Chaoyang, Qiao, Zhen, Liao, Yikai, Zhu, Song, Lu, Hongxu, Nie, Ningyuan, Zhou, Tian, Kim, Munho, Huang, Changjin, Soh, Boon Seng, Chen, Yu-Cheng

“…Mechanical stress within organoids is a pivotal indicator in disease modeling and pharmacokinetics, yet current tools lack the ability to rapidly and…”
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Wnt/[beta]-catenin-mediated signaling re-activates proliferation of matured cardiomyocytes by Fan, Yong, Ho, Beatrice Xuan, Pang, Jeremy Kah Sheng, Pek, Nicole Min Qian, Hor, Jin Hui, Ng, Shi-Yan, Soh, Boon-Seng

“…Background The Wnt/[beta]-catenin signaling pathway plays an important role in the development of second heart field (SHF Isl1+) that gives rise to the…”
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Cell cycle inhibitors protect motor neurons in an organoid model of Spinal Muscular Atrophy by Hor, Jin Hui, Soh, Eunice Shi-Yi, Tan, Li Yi, Lim, Valerie Jing Wen, Santosa, Munirah Mohamad, Winanto, Ho, Beatrice Xuan, Fan, Yong, Soh, Boon-Seng, Ng, Shi-Yan

“…Spinal Muscular Atrophy (SMA) is caused by genetic mutations in the SMN1 gene, resulting in drastically reduced levels of Survival of Motor Neuron (SMN)…”
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Upregulation of the JAK-STAT pathway promotes maturation of human embryonic stem cell-derived cardiomyocytes by Ho, Beatrice Xuan, Yu, Hongbing, Pang, Jeremy Kah Sheng, Hor, Jin-Hui, Liew, Lee Chuen, Szyniarowski, Piotr, Lim, Christina Ying Yan, An, Omer, Yang, Henry He, Stewart, Colin L., Chan, Woon Khiong, Ng, Shi-Yan, Soh, Boon-Seng

“…The immature characteristics and metabolic phenotypes of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) restrict their applications for disease…”
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