Search Results - "Ho, Angela"

The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes by Davydova, Erna, Shimazu, Tadahiro, Schuhmacher, Maren Kirstin, Jakobsson, Magnus E., Willemen, Hanneke L. D. M., Liu, Tongri, Moen, Anders, Ho, Angela Y. Y., Małecki, Jędrzej, Schroer, Lisa, Pinto, Rita, Suzuki, Takehiro, Grønsberg, Ida A., Sohtome, Yoshihiro, Akakabe, Mai, Weirich, Sara, Kikuchi, Masaki, Olsen, Jesper V., Dohmae, Naoshi, Umehara, Takashi, Sodeoka, Mikiko, Siino, Valentina, McDonough, Michael A., Eijkelkamp, Niels, Schofield, Christopher J., Jeltsch, Albert, Shinkai, Yoichi, Falnes, Pål Ø.

“…Post-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers…”
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The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A) by Malecki, Jedrzej, Aileni, Vinay Kumar, Ho, Angela Y Y, Schwarz, Juliane, Moen, Anders, Sørensen, Vigdis, Nilges, Benedikt S, Jakobsson, Magnus E, Leidel, Sebastian A, Falnes, Pål Ø

“…Lysine methylation is abundant on histone proteins, representing a dynamic regulator of chromatin state and gene activity, but is also frequent on many…”
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Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation by Małecki, Jędrzej, Jakobsson, Magnus E., Ho, Angela Y.Y., Moen, Anders, Rustan, Arild C., Falnes, Pål Ø.

“…Lysine methylation is an important and much-studied posttranslational modification of nuclear and cytosolic proteins but is present also in mitochondria…”
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Human METTL20 Is a Mitochondrial Lysine Methyltransferase That Targets the β Subunit of Electron Transfer Flavoprotein (ETFβ) and Modulates Its Activity by Małecki, Jędrzej, Ho, Angela Y.Y., Moen, Anders, Dahl, Helge-André, Falnes, Pål Ø.

“…Proteins are frequently modified by post-translational methylation of lysine residues, catalyzed by S-adenosylmethionine-dependent lysine methyltransferases…”
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Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration by Małecki, Jędrzej M., Willemen, Hanneke L.D.M., Pinto, Rita, Ho, Angela Y.Y., Moen, Anders, Eijkelkamp, Niels, Falnes, Pål Ø.

“…Lysine methylation is a common posttranslational modification of nuclear and cytoplasmic proteins but is also present in mitochondria. The human protein…”
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Identification and Characterization of a Novel Evolutionarily Conserved Lysine-specific Methyltransferase Targeting Eukaryotic Translation Elongation Factor 2 (eEF2) by Davydova, Erna, Ho, Angela Y.Y., Malecki, Jedrzej, Moen, Anders, Enserink, Jorrit M., Jakobsson, Magnus E., Loenarz, Christoph, Falnes, Pål Ø.

“…The components of the cellular protein translation machinery, such as ribosomal proteins and translation factors, are subject to numerous post-translational…”
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APOER2 splicing repertoire in Alzheimer's disease: Insights from long-read RNA sequencing by Gallo, Christina M, Kistler, Sabrina A, Natrakul, Anna, Labadorf, Adam T, Beffert, Uwe, Ho, Angela

“…Disrupted alternative splicing plays a determinative role in neurological diseases, either as a direct cause or as a driver in disease susceptibility…”
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Suicide: Rationality and Responsibility for Life by Ho, Angela Onkay

“…Objectives: Death by suicide is widely held as an undesirable outcome. Most Western countries place emphasis on patient autonomy, a concept of controversy in…”
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Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase by Małecki, Jędrzej M., Willemen, Hanneke L.D.M., Pinto, Rita, Ho, Angela Y.Y., Moen, Anders, Kjønstad, Ingrid F., Burgering, Boudewijn M.T., Zwartkruis, Fried, Eijkelkamp, Niels, Falnes, Pål Ø.

“…Lysine methylation is an important post-translational modification that is also present on mitochondrial proteins, but the mitochondrial lysine-specific…”
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Surface texture limits transfer of S. aureus, T4 bacteriophage, influenza B virus and human coronavirus by Liu, Qi, Brookbank, Lindsey, Ho, Angela, Coffey, Jenna, Brennan, Anthony B, Jones, Christopher J

“…Spread of pathogens on contaminated surfaces plays a key role in disease transmission. Surface technologies that control pathogen transfer can help control…”
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Excess mortality for operated geriatric hip fracture in Hong Kong by Man, L P, Ho, A Wh, Wong, S H

“…Geriatric hip fracture places an increasing burden to health care systems around the world. We studied the latest epidemiology trend of geriatric hip fracture…”
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Experiential Psychotherapy Training is Essential for Residents by Villela, Renata M., Bawks, Jordan, Weir, Heather, Weir, Doug, Ho, Angela O., Kljenak, Diana, Ahmad, Yusra, Amanullah, Shabbir, Fung, Kenneth, Petit, Lyndal

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FOXR1 regulates stress response pathways and is necessary for proper brain development by Mota, Andressa, Waxman, Hannah K, Hong, Rui, Lagani, Gavin D, Niu, Sheng-Yong, Bertherat, Féodora L, Wolfe, Lynne, Malicdan, Christine May, Markello, Thomas C, Adams, David R, Gahl, William A, Cheng, Christine S, Beffert, Uwe, Ho, Angela

“…The forkhead box (Fox) family of transcription factors are highly conserved and play essential roles in a wide range of cellular and developmental processes…”
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Retrospective review on tenolysis after phalangeal fractures: A Hong Kong local center experience by Wong, Yan Yu Ruby, Ho, Angela Wing-Hang, Ho, Sheung Tung

“…Background/Purpose: This is a local retrospective review on the outcomes of tenolysis after phalangeal fracture. Methods: The clinical outcome of nine patients…”
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ApoER2: Functional Tuning Through Splicing by Gallo, Christina M, Ho, Angela, Beffert, Uwe

“…Alternative splicing occurs in over 95% of protein-coding genes and contributes to the diversity of the human proteome. Apolipoprotein E receptor 2 (apoER2) is…”
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Post-fracture care gap: a retrospective population-based analysis of Hong Kong from 2009 to 2012 by Cheung, M Y, Ho, A Wh, Wong, S H

“…Patients who sustain an osteoporotic fracture are at increased risk of sustaining further osteoporotic fracture. The risk can be reduced by prescription of…”
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Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis by Mukherjee, Konark, Yang, Xiaofei, Gerber, Stefan H., Kwon, Hyung-Bae, Ho, Angela, Castillo, Pablo E., Liu, Xinran, Südhof, Thomas C.

“…Piccolo and bassoon are highly homologous multidomain proteins of the presynaptic cytomatrix whose function is unclear. Here, we generated piccolo…”
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CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development by Dillon, Gregory M., Tyler, William A., Omuro, Kerilyn C., Kambouris, John, Tyminski, Camila, Henry, Shawna, Haydar, Tarik F., Beffert, Uwe, Ho, Angela

“…The Reelin signaling pathway plays a crucial role in regulating neocortical development. However, little is known about how Reelin controls the cytoskeleton…”
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Early surgery for Hong Kong Chinese elderly patients with hip fracture reduces short-term and long-term mortality by Liu, S Kk, Ho, A Wh, Wong, S H

“…Studies have shown that early surgery reduces hospital and 1-year mortality in elderly patients with hip fracture, but no major study has examined such…”
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Prevalence of pre-sarcopenia and sarcopenia in Hong Kong Chinese geriatric patients with hip fracture and its correlation with different factors by Ho, A Wh, Lee, M Ml, Chan, E Wc, Ng, H My, Lee, C W, Ng, W S, Wong, S H

“…Sarcopenia and osteoporosis are age-related declines in the quantity of muscle and bone, respectively. Both contribute in disability, fall, and hip fracture in…”
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