Search Results - "Hnedzko, Dziyana"

Triple-Helical Binding of Peptide Nucleic Acid Inhibits Maturation of Endogenous MicroRNA-197 by Endoh, Tamaki, Brodyagin, Nikita, Hnedzko, Dziyana, Sugimoto, Naoki, Rozners, Eriks

“…Sequence specific recognition and functional inhibition of biomedically relevant double-helical RNAs is highly desirable but remains a formidable problem. The…”
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Sequence-selective recognition of double-stranded RNA and enhanced cellular uptake of cationic nucleobase and backbone-modified peptide nucleic acids by Hnedzko, Dziyana, McGee, Dennis W, Karamitas, Yannis A, Rozners, Eriks

“…Sequence-selective recognition of complex RNAs in live cells could find broad applications in biology, biomedical research, and biotechnology. However,…”
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Nucleobase-Modified Triplex-Forming Peptide Nucleic Acids for Sequence-Specific Recognition of Double-Stranded RNA by Brodyagin, Nikita, Hnedzko, Dziyana, MacKay, James A, Rozners, Eriks

“…Because of the important roles noncoding RNAs play in gene expression, their sequence-specific recognition is important for both fundamental science and the…”
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Using triple-helix-forming Peptide nucleic acids for sequence-selective recognition of double-stranded RNA by Hnedzko, Dziyana, Cheruiyot, Samwel K, Rozners, Eriks

“…Non-coding RNAs play important roles in regulation of gene expression. Specific recognition and inhibition of these biologically important RNAs that form…”
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Sequence-specific recognition of structured RNA by triplex-forming peptide nucleic acids by Hnedzko, Dziyana, Rozners, Eriks

“…While <2% of DNA encodes for functional proteins, >70% is transcribed into RNA. Although the function of most RNA transcripts is unknown, such non-coding RNAs…”
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Nucleobase-Modified PNA Suppresses Translation by Forming a Triple Helix with a Hairpin Structure in mRNA InVitro and in Cells by Endoh, Tamaki, Hnedzko, Dziyana, Rozners, Eriks, Sugimoto, Naoki

“…Compounds that bind specifically to double-stranded regions of RNA have potential as regulators of structure-based RNA function; however, sequence-selective…”
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Nucleobase-Modified PNA Suppresses Translation by Forming a Triple Helix with a Hairpin Structure in mRNA In Vitro and in Cells by Endoh, Tamaki, Hnedzko, Dziyana, Rozners, Eriks, Sugimoto, Naoki

“…Compounds that bind specifically to double‐stranded regions of RNA have potential as regulators of structure‐based RNA function; however, sequence‐selective…”
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Triplex-forming peptide nucleic acid modified with 2-aminopyridine as a new tool for detection of A-to-I editing by Annoni, Chiara, Endoh, Tamaki, Hnedzko, Dziyana, Rozners, Eriks, Sugimoto, Naoki

“…RNA editing from adenosine to inosine (A-to-I editing) is one of the mechanisms that regulate and diversify the transcriptome. Here, a triplex-forming peptide…”
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Synthesis and properties of peptide nucleic acid labeled at the N-terminus with HiLyte Fluor 488 fluorescent dye by Hnedzko, Dziyana, McGee, Dennis W., Rozners, Eriks

“…[Display omitted] Fluorescently labeled peptide nucleic acids (PNAs) are important tools in fundamental research and biomedical applications. However,…”
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Cover Picture: Nucleobase-Modified PNA Suppresses Translation by Forming a Triple Helix with a Hairpin Structure in mRNA InVitro and in Cells by Endoh, Tamaki, Hnedzko, Dziyana, Rozners, Eriks, Sugimoto, Naoki

“…The biological activity of triplex-forming peptide nucleic acid (PNA) modified with unnatural nucleobases is described by N. Sugimoto and co-workers in their…”
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Cover Picture: Nucleobase-Modified PNA Suppresses Translation by Forming a Triple Helix with a Hairpin Structure in mRNA In Vitro and in Cells (Angew. Chem. Int. Ed. 3/2016) by Endoh, Tamaki, Hnedzko, Dziyana, Rozners, Eriks, Sugimoto, Naoki

“…The biological activity of triplex‐forming peptide nucleic acid (PNA) modified with unnatural nucleobases is described by N. Sugimoto and co‐workers in their…”
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Breaking the Fourth Wall: Modulating Quaternary Associations for Protein Regulation and Drug Discovery by Long, Marcus J. C., Hnedzko, Dziyana, Kim, Bo Kyoung, Aye, Yimon

“…Protein–protein interactions (PPIs) are an effective means to orchestrate intricate biological processes required to sustain life. Approximately 650 000 PPIs…”
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Sequence Selective Recognition of Double-Stranded RNA at Physiologically Relevant Conditions Using PNA-Peptide Conjugates by Muse, Oluwatoyosi, Zengeya, Thomas, Mwaura, Juddy, Hnedzko, Dziyana, McGee, Dennis W, Grewer, Christof T, Rozners, Eriks

“…Conjugation of short peptide nucleic acids (PNA) with tetralysine peptides strongly enhanced triple helical binding to RNA at physiologically relevant…”
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Sequence-Selective Recognition of Double-Stranded RNA and Enhanced Cellular Uptake of Cationic Nucleobase and Backbone-Modified Peptide Nucleic Acids by Hnedzko, Dziyana

“…The important role that RNA plays in gene regulation, catalysis, immunomodulation, DNA cleavage and editing makes it an attractive target for molecular…”
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Nucleobase-Modified PNA Suppresses Translation by Forming a Triple Helix with a Hairpin Structure in mRNA InVitro and in Cells by Endoh, Tamaki, Hnedzko, Dziyana, Rozners, Eriks, Sugimoto, Naoki

“…Compounds that bind specifically to double-stranded regions of RNA have potential as regulators of structure-based RNA function; however, sequence-selective…”
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Nucleobase-Modified PNA Suppresses Translation by Forming a Triple Helix with a Hairpin Structure in mRNA In Vitro and in Cells by Endoh, Tamaki, Hnedzko, Dziyana, Rozners, Eriks, Sugimoto, Naoki

“…Compounds that bind specifically to double‐stranded regions of RNA have potential as regulators of structure‐based RNA function; however, sequence‐selective…”
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Titelbild: Nucleobase-Modified PNA Suppresses Translation by Forming a Triple Helix with a Hairpin Structure in mRNA In Vitro and in Cells (Angew. Chem. 3/2016) by Endoh, Tamaki, Hnedzko, Dziyana, Rozners, Eriks, Sugimoto, Naoki

“…Die biologische Aktivität einer triplexbildenden Peptidnucleinsäure (PNA), die nichtnatürliche Nucleobasen enthält, wird von N. Sugimoto et al. in der…”
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