Search Results - "Hlavac, Jan"

Novel Peptide-Based Fluorescent Probe for Simultaneous Sensing of Chymotrypsin and Hydrogen Peroxide by Milićević, David, Hlaváč, Jan

“…The developed multifunctional fluorescent probe enables the simultaneous detection of chymotrypsin as a model protease and hydrogen peroxide as a…”
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Novel ratiometric xanthene-based probes for protease detection by Okorochenkova, Yana, Hlaváč, Jan

“…Novel FRET and donor-fluorescent quencher systems based on fluorescein-rhodamine B fluorophores have been developed as protease detectors and their…”
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BODIPY-aza-indole derivate complex as a selective fluorescent sensor for autolysosomes detection by Okorochenkov, Sergii, Skrott, Zdenek, Majera, Dusana, Porubský, Martin, Mistrik, Martin, Hlaváč, Jan

“…Autophagy is a process of removal and degradation of unneeded or damaged cellular components, which plays an essential role in several physiological processes…”
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Triple-FRET multi-purpose fluorescent probe for three-protease detection by Mili evi, David, Hlavá, Jan

“…A new, robust and reliable methodology for three-protease screening in a single-enzyme mode has been developed and verified, employing a multi-purpose peptide…”
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Determination of Energy Losses of the Crank Press Mechanism by Hlavac, Jan, Dekastello, Jiri

“…This paper focuses on determining the friction energy loss in the mechanism of a mechanical crank press. After defining the crank press mechanism and how it…”
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Near-infrared pH-switchable BODIPY photosensitizers for dual biotin/cRGD targeted photodynamic therapy by Porubský, Martin, Hodoň, Jiří, Stanková, Jarmila, Džubák, Petr, Hajdúch, Marián, Urban, Milan, Hlaváč, Jan

“…Photodynamic therapy (PDT) is a clinically-approved cancer treatment that is based on production of cytotoxic reactive oxygen species to induce cell death…”
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AminoBODIPY Conjugates for Targeted Drug Delivery Systems and Real-Time Monitoring of Drug Release by Porubský, Martin, Gurská, Soňa, Stanková, Jarmila, Hajdúch, Marián, Džubák, Petr, Hlaváč, Jan

“…In this work, we report two concepts of drug delivery based on small-molecule drug conjugates with the ability of specific targeting and drug release…”
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Polymer-supported synthesis of N -substituted anthranilates as the building blocks for preparation of N -arylated 3-hydroxyquinolin-4(1 H )-ones by Krajčovičová, Soňa, Hlaváč, Jan, Vychodilová, Kristýna

“…Fast and simple access to -arylated 3-hydroxyquinolin-4(1 )-ones starting from easily available 1-methyl-2-iodoterephthalate and variously substituted anilines…”
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RP-HPLC determination of dissociation constant using solely aqueous mobile phase by Volná, Tereza, Motyka, Kamil, Hlaváč, Jan

“…•The proposed HPLC method uses solely or nearly 100% aqueous mobile buffer as mobile phase.•The method offers fast determination of dissociation constant for…”
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Development of fluorescent dual-FRET probe for simultaneous detection of caspase-8 and caspase-9 activities and their relative quantification by Porubský, Martin, Řezníčková, Eva, Křupková, Soňa, Kryštof, Vladimír, Hlaváč, Jan

“…[Display omitted] •The fluorescent sensor can distinguish activity of Casp8 and Casp9 presented solely or simultaneously in cell lysates.•Evaluation model…”
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Fluorinated derivatives of 2-phenyl-3-hydroxy-4(1H)-quinolinone as tubulin polymerization inhibitors by Řehulka, Jiří, Vychodilová, Kristýna, Krejčí, Petr, Gurská, Soňa, Hradil, Pavel, Hajdúch, Marián, Džubák, Petr, Hlaváč, Jan

“…We have synthesized a series of 2-phenyl-3-hydroxy-4(1H)-quinolinone derivatives substituted with one or more fluorine atoms on the quinolone backbone as well…”
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Drug-like Inhibitors of DC-SIGN Based on a Quinolone Scaffold by Zhang, Hengxi, Daněk, Ondřej, Makarov, Dmytro, Rádl, Stanislav, Kim, Dongyoon, Ledvinka, Jiří, Vychodilová, Kristýna, Hlaváč, Jan, Lefèbre, Jonathan, Denis, Maxime, Rademacher, Christoph, Ménová, Petra

“…DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin) is a pattern recognition receptor expressed on immune cells and…”
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Effects of Ginger Phenylpropanoids and Quercetin on Nrf2-ARE Pathway in Human BJ Fibroblasts and HaCaT Keratinocytes by Hajdúch, Marián, Varanasi, Lakshman, Volná, Tereza, Hlaváč, Jan, Schadich, Ermin, Džubák, Petr

“…Quercetin and phenylpropanoids are well known chemoprotective compounds identified in many plants. This study was aimed at determining their effects on…”
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Amino-BODIPY as the ratiometric fluorescent sensor for monitoring drug release or "power supply" selector for molecular electronics by Porubský, Martin, Gurská, So a, Stanková, Jarmila, Hajdúch, Marián, D ubák, Petr, Hlavá, Jan

“…The glutathione cleavable conjugates of amino-BODIPY dye with model drugs have been tested for monitoring the drug release via ratiometric fluorescence based…”
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Potential of High-Performance Liquid Chromatography for Distribution Coefficient Determination of 3-Hydroxyquinolin-4(1H)-one Derivatives by Volná, Tereza, Motyka, Kamil, Hlaváč, Jan

“…The potential of reversed-phase HPLC for the determination of distribution coefficient D 7.4 of selected 3-hydroxyquinolin-4(1H)-ones (3HQs) as compounds with…”
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Study of 2-aminoquinolin-4(1H)-one under Mannich and retro-Mannich reaction by Funk, Petr, Motyka, Kamil, Soural, Miroslav, Malon, Michal, Koshino, Hiroyuki, Kusz, Joachim, Hlavac, Jan

“…2-Aminoquinolin-4(1H)-one was reacted with various primary/secondary amines and paraformaldehyde under Mannich reaction conditions. In the case of secondary…”
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Meropenem population pharmacokinetics and model-based dosing optimisation in patients with serious bacterial infection by Murínová, Irena, Švidrnoch, Martin, Gucký, Tomáš, Řezáč, David, Hlaváč, Jan, Slanař, Ondřej, Šíma, Martin

“…The objective of this study was to develop a population pharmacokinetic model of meropenem in a heterogeneous population of patients with a serious bacterial…”
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Synthesis of oxidative dihydroxy metabolites of benzo[c]phenanthridines by Styskala, Jakub, Hlavac, Jan, Cankar, Petr

“…The synthesis of dihydroxybenzo[c]phenanthridines is described. 6-Bromo-2,3-dihydroxybenzaldehyde was reacted with naphtho[2,3-d][1,3]dioxol-5-amine via…”
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7-(2-Thienyl)-7-Deazaadenosine (AB61), a New Potent Nucleoside Cytostatic with a Complex Mode of Action by Perlíková, Pavla, Rylová, Gabriela, Nauš, Petr, Elbert, Tomáš, Tloušťová, Eva, Bourderioux, Aurelie, Slavětínská, Lenka Poštová, Motyka, Kamil, Doležal, Dalibor, Znojek, Pawel, Nová, Alice, Harvanová, Monika, Džubák, Petr, Šiller, Michal, Hlaváč, Jan, Hajdúch, Marián, Hocek, Michal

“…7-(2-Thienyl)-7-deazaadenosine (AB61) showed nanomolar cytotoxic activities against various cancer cell lines but only mild (micromolar) activities against…”
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Bis-Rhodamine B System as a Tin Detector or Molecular Electronics Device by Brulíkova, Lucie, Volná, Tereza, Hlavac, Jan

“…In this report, fluorescent systems consisting of two Rhodamine B moieties were designed and synthesized employing the solid-phase synthetic approach. The…”
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