Search Results - "Hlaváč, Jan"

Fluorescence-Based On-Resin Detection of Three Model Proteases by Milićević, David, Hlaváč, Jan

“…A new approach to on-resin detection of three model proteases (trypsin, chymotrypsin, and thrombin) has been developed, while at the same time already…”
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Stereo- and regioselectivity of the hetero-Diels-Alder reaction of nitroso derivatives with conjugated dienes by Brulíková, Lucie, Harrison, Aidan, Miller, Marvin J, Hlaváč, Jan

“…The hetero-Diels-Alder reaction between a nitroso dienophile and a conjugated diene to give the 3,6-dihydro-2 -1,2-oxazine scaffold is useful for the synthesis…”
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Immobilized Fluorescent Probes for Simultaneous Multiple Protease Detection by Milićević, David, Hlaváč, Jan

“…A new concept for simultaneous detection of two model proteases based on immobilized fluorescently labelled peptides was developed and evaluated. Each probe…”
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4‑Chloro-2-Fluoro-5-Nitrobenzoic Acid as a Possible Building Block for Solid-phase Synthesis of Various Heterocyclic Scaffolds by Křupková, Soňa, Funk, Petr, Soural, Miroslav, Hlaváč, Jan

“…4-Chloro-2-fluoro-5-nitrobenzoic acid is a commercially available multireactive building block that can serve as a starting material in heterocyclic oriented…”
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Population Pharmacokinetic Analysis Proves Superiority of Continuous Infusion in PK/PD Target Attainment with Oxacillin in Staphylococcal Infections by Murínová, Irena, Švidrnoch, Martin, Gucký, Tomáš, Hlaváč, Jan, Michálek, Pavel, Slanař, Ondřej, Šíma, Martin

“…Considering its very short elimination half-life, the approved oxacillin dosage might not be sufficient to maintain the pharmacokinetic/pharmacodynamics…”
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Cytotoxicity of Amino‐BODIPY Modulated via Conjugation with 2‐Phenyl‐3‐Hydroxy‐4(1H)‐Quinolinones by Porubský, Martin, Vychodilová, Kristýna, Milićević, David, Buděšinský, Miloš, Stanková, Jarmila, Džubák, Petr, Hajdúch, Marián, Hlaváč, Jan

“…The combination of cytotoxic amino‐BODIPY dye and 2‐phenyl‐3‐hydroxy‐4(1H)‐quinolinone (3‐HQ) derivatives into one molecule gave rise to selective activity…”
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Recent Synthetic Approaches to 1H- and 2H-Indazoles. A Review by Cankařová, Naděžda, Hlaváč, Jan, Krchňák, Viktor

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Novel Peptide-Based Fluorescent Probe for Simultaneous Sensing of Chymotrypsin and Hydrogen Peroxide by Milićević, David, Hlaváč, Jan

“…The developed multifunctional fluorescent probe enables the simultaneous detection of chymotrypsin as a model protease and hydrogen peroxide as a…”
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Novel ratiometric xanthene-based probes for protease detection by Okorochenkova, Yana, Hlaváč, Jan

“…Novel FRET and donor-fluorescent quencher systems based on fluorescein-rhodamine B fluorophores have been developed as protease detectors and their…”
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BODIPY-aza-indole derivate complex as a selective fluorescent sensor for autolysosomes detection by Okorochenkov, Sergii, Skrott, Zdenek, Majera, Dusana, Porubský, Martin, Mistrik, Martin, Hlaváč, Jan

“…Autophagy is a process of removal and degradation of unneeded or damaged cellular components, which plays an essential role in several physiological processes…”
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Triple-FRET multi-purpose fluorescent probe for three-protease detection by Mili evi, David, Hlavá, Jan

“…A new, robust and reliable methodology for three-protease screening in a single-enzyme mode has been developed and verified, employing a multi-purpose peptide…”
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Determination of Energy Losses of the Crank Press Mechanism by Hlavac, Jan, Dekastello, Jiri

“…This paper focuses on determining the friction energy loss in the mechanism of a mechanical crank press. After defining the crank press mechanism and how it…”
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Near-infrared pH-switchable BODIPY photosensitizers for dual biotin/cRGD targeted photodynamic therapy by Porubský, Martin, Hodoň, Jiří, Stanková, Jarmila, Džubák, Petr, Hajdúch, Marián, Urban, Milan, Hlaváč, Jan

“…Photodynamic therapy (PDT) is a clinically-approved cancer treatment that is based on production of cytotoxic reactive oxygen species to induce cell death…”
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AminoBODIPY Conjugates for Targeted Drug Delivery Systems and Real-Time Monitoring of Drug Release by Porubský, Martin, Gurská, Soňa, Stanková, Jarmila, Hajdúch, Marián, Džubák, Petr, Hlaváč, Jan

“…In this work, we report two concepts of drug delivery based on small-molecule drug conjugates with the ability of specific targeting and drug release…”
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Polymer-supported synthesis of N -substituted anthranilates as the building blocks for preparation of N -arylated 3-hydroxyquinolin-4(1 H )-ones by Krajčovičová, Soňa, Hlaváč, Jan, Vychodilová, Kristýna

“…Fast and simple access to -arylated 3-hydroxyquinolin-4(1 )-ones starting from easily available 1-methyl-2-iodoterephthalate and variously substituted anilines…”
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RP-HPLC determination of dissociation constant using solely aqueous mobile phase by Volná, Tereza, Motyka, Kamil, Hlaváč, Jan

“…•The proposed HPLC method uses solely or nearly 100% aqueous mobile buffer as mobile phase.•The method offers fast determination of dissociation constant for…”
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Development of fluorescent dual-FRET probe for simultaneous detection of caspase-8 and caspase-9 activities and their relative quantification by Porubský, Martin, Řezníčková, Eva, Křupková, Soňa, Kryštof, Vladimír, Hlaváč, Jan

“…[Display omitted] •The fluorescent sensor can distinguish activity of Casp8 and Casp9 presented solely or simultaneously in cell lysates.•Evaluation model…”
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Fluorinated derivatives of 2-phenyl-3-hydroxy-4(1H)-quinolinone as tubulin polymerization inhibitors by Řehulka, Jiří, Vychodilová, Kristýna, Krejčí, Petr, Gurská, Soňa, Hradil, Pavel, Hajdúch, Marián, Džubák, Petr, Hlaváč, Jan

“…We have synthesized a series of 2-phenyl-3-hydroxy-4(1H)-quinolinone derivatives substituted with one or more fluorine atoms on the quinolone backbone as well…”
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Drug-like Inhibitors of DC-SIGN Based on a Quinolone Scaffold by Zhang, Hengxi, Daněk, Ondřej, Makarov, Dmytro, Rádl, Stanislav, Kim, Dongyoon, Ledvinka, Jiří, Vychodilová, Kristýna, Hlaváč, Jan, Lefèbre, Jonathan, Denis, Maxime, Rademacher, Christoph, Ménová, Petra

“…DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin) is a pattern recognition receptor expressed on immune cells and…”
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Effects of Ginger Phenylpropanoids and Quercetin on Nrf2-ARE Pathway in Human BJ Fibroblasts and HaCaT Keratinocytes by Hajdúch, Marián, Varanasi, Lakshman, Volná, Tereza, Hlaváč, Jan, Schadich, Ermin, Džubák, Petr

“…Quercetin and phenylpropanoids are well known chemoprotective compounds identified in many plants. This study was aimed at determining their effects on…”
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