Search Results - "Hjuler, Sara Toftegaard"

Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias by Andreassen, Kim Vietz, Hjuler, Sara Toftegaard, Furness, Sebastian G, Sexton, Patrick M, Christopoulos, Arthur, Nosjean, Olivier, Karsdal, Morten Asser, Henriksen, Kim

“…Salmon calcitonin (sCT) and human calcitonin (hCT) are pharmacologically distinct. However, the reason for the differences is unclear. Here we analyze the…”
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Standard procedures for blood withdrawal in conscious male rats induce stress and profoundly affect glucose tolerance and secretion of glucoregulatory hormones by Pedersen, Kent, Andersen, Helle, Fledelius, Christian, Holst, Jens Juul, Hjuler, Sara Toftegaard, Kuhre, Rune Ehrenreich

“…A fundamental difference between physiological and pharmacological studies in rats and humans is that withdrawal of blood from conscious rats necessitates…”
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A novel dual amylin and calcitonin receptor agonist, KBP‐089, induces weight loss through a reduction in fat, but not lean mass, while improving food preference by Gydesen, Sofie, Hjuler, Sara Toftegaard, Freving, Zenia, Andreassen, Kim Vietz, Sonne, Nina, Hellgren, Lars I, Karsdal, Morten Asser, Henriksen, Kim

“…Background and Purpose Obesity and associated co‐morbidities, such as type 2 diabetes and non‐alcoholic fatty liver disease, are major health challenges…”
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Optimization of tolerability and efficacy of the novel dual amylin and calcitonin receptor agonist KBP-089 through dose escalation and combination with a GLP-1 analog by Gydesen, Sofie, Andreassen, Kim Vietz, Hjuler, Sara Toftegaard, Hellgren, Lars I, Karsdal, Morten Asser, Henriksen, Kim

“…Amylin and GLP-1 agonism induce a well-known anorexic effect at dose initiation, which is managed by dose escalation. In this study we investigated how to…”
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KBP-088, a novel DACRA with prolonged receptor activation, is superior to davalintide in terms of efficacy on body weight by Gydesen, Sofie, Andreassen, Kim Vietz, Hjuler, Sara Toftegaard, Christensen, Jane Marie, Karsdal, Morten Asser, Henriksen, Kim

“…This study aims to elucidate the mechanism behind the potent weight loss induced by dual amylin and calcitonin receptor agonists (DACRA) through comparison of…”
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The dual amylin‐ and calcitonin‐receptor agonist KBP‐042 increases insulin sensitivity and induces weight loss in rats with obesity by Hjuler, Sara Toftegaard, Gydesen, Sofie, Andreassen, Kim Vietz, Pedersen, Steffen Lund Kjær, Hellgren, Lars I., Karsdal, Morten Asser, Henriksen, Kim

“…Objective In this study, KBP‐042, a dual amylin‐ and calcitonin‐receptor agonist, was investigated as a treatment of obesity and insulin resistance in five…”
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Is there a murine model that fully recapitulates human NASH? An unbiased bioinformatics approach to rank pre-clinical models based on proximity to human disease by Vacca, Michele, Kamzolas, Ioannis, Harder, Lea Mørch, Oakley, Fiona, Trautwein, Christian, Hatting, Maximilian, Ross, Trenton, Bernardo, Barbara, Oldenburger, Anouk, Hjuler, Sara Toftegaard, Ksiazek, Iwona, Linden, Daniel, Schuppan, Detlef, Rodriguez-Cuenca, Sergio, Tonini, Maria Manuela, Kannt, Aimo, Rodriguez-Castaneda, Tamara, Rodrigues, Cecília M.P, Cockell, Simon, Govaere, Olivier, Daly, Ann K., Allison, Michael, de Lichtenberg, Kristian Honnens, Kim, Yong Ook, Lindblom, Anna, Oldham, Stephanie, Andréasson, Anne-Christine, Schlerman, Franklin, Marioneaux, Jonathon, Sanyal, Arun, Afonso, Marta B., Rinaldi, Anthony, Amano, Yuichiro, Paradis, Valérie, Burt, Alastair, Susan, Davies, Driessen, Ann, Yashiro, Hiroaki, Brosnan, M.Juli, Yunis, Carla, Bedossa, Pierre, Tiniakos, Dina, Anstee, Quentin, Petsalaki, Evangelia, Davidsen, Peter, Perfield, Jim, Vidal-Puig, Antonio

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Hepatocyte mARC1 promotes fatty liver disease by Lewis, Lara C., Chen, Lingyan, Hameed, L. Shahul, Kitchen, Robert R., Maroteau, Cyrielle, Nagarajan, Shilpa R., Norlin, Jenny, Daly, Charlotte E., Szczerbinska, Iwona, Hjuler, Sara Toftegaard, Patel, Rahul, Livingstone, Eilidh J., Durrant, Tom N., Wondimu, Elisabeth, BasuRay, Soumik, Chandran, Anandhakumar, Lee, Wan-Hung, Hu, Sile, Gilboa, Barak, Grandi, Megan E., Toledo, Enrique M., Erikat, Abdullah H.A., Hodson, Leanne, Haynes, William G., Pursell, Natalie W., Coppieters, Ken, Fleckner, Jan, Howson, Joanna M.M., Andersen, Birgitte, Ruby, Maxwell A.

“…Non-alcoholic fatty liver disease (NAFLD) has a prevalence of ∼25% worldwide, with significant public health consequences yet few effective treatments. Human…”
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Prolonged Calcitonin Receptor Signaling by Salmon, but Not Human Calcitonin, Reveals Ligand Bias: e92042 by Andreassen, Kim Vietz, Hjuler, Sara Toftegaard, Furness, Sebastian G, Sexton, Patrick M, Christopoulos, Arthur, Nosjean, Olivier, Karsdal, Morten Asser, Henriksen, Kim

“…Salmon calcitonin (sCT) and human calcitonin (hCT) are pharmacologically distinct. However, the reason for the differences is unclear. Here we analyze the…”
Get full text