Search Results - "Hjortrup, P. B."

Association between fluid balance and mortality in patients with septic shock: a post hoc analysis of the TRISS trial by Cronhjort, M., Hjortrup, P. B., Holst, L. B., Joelsson-Alm, E., Mårtensson, J., Svensen, C., Perner, A.

“…Background Several studies have shown an association between a positive fluid balance and increased mortality in patients with septic shock. This may have led…”
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Lower vs. higher fluid volumes in sepsis—protocol for a systematic review with meta‐analysis by Meyhoff, T. S., Møller, M. H., Hjortrup, P. B., Cronhjort, M., Perner, A., Wetterslev, J.

“…Background Intravenous fluid administration with crystalloids is recommended in the initial management of sepsis. However, the quality of evidence supporting…”
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Development and internal validation of the Simplified Mortality Score for the Intensive Care Unit (SMS‐ICU) by Granholm, A., Perner, A., Krag, M., Hjortrup, P. B., Haase, N., Holst, L. B., Marker, S., Collet, M. O., Jensen, A. K. G., Møller, M. H.

“…Background Intensive care unit (ICU) mortality prediction scores deteriorate over time, and their complexity decreases clinical applicability and commonly…”
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Predictive value of NGAL for use of renal replacement therapy in patients with severe sepsis by HJORTRUP, P. B., HAASE, N., TRESCHOW, F., MØLLER, M. H., PERNER, A.

“…Background The predictive value of plasma and urine neutrophil gelatinase‐associated lipocalin (NGAL) for use of renal replacement therapy (RRT) and acute…”
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Effects of fluid restriction on measures of circulatory efficacy in adults with septic shock by Hjortrup, P. B., Haase, N., Wetterslev, J., Lange, T., Bundgaard, H., Rasmussen, B. S., Dey, N., Wilkman, E., Christensen, L., Lodahl, D., Bestle, M., Perner, A.

“…Background The haemodynamic consequences of fluid resuscitation in septic shock have not been fully elucidated. Therefore, we assessed circulatory effects in…”
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Factors associated with non‐response at health‐related quality of life follow‐up in a septic shock trial by Kjær, M. N., Mortensen, C. B., Hjortrup, P. B., Rygård, S. L., Andersen, I., Perner, A.

“…Background Follow‐up of intensive care unit (ICU) patients often includes health‐related quality of life (HRQoL) surveying, but non‐responders hamper the…”
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Use of life support in acutely admitted ICU patients. An international cohort study by Meyhoff, T. S., Krag, M., Hjortrup, P. B., Perner, A., Møller, M. H.

“…Background Use of life support in intensive care unit (ICU) patients has been associated with increased risk of poor outcome. The prognostic importance of the…”
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Effects of hydroxyethyl starch 130/0.42 vs. Ringer's acetate on cytokine levels in severe sepsis by Anthon, C. T., Müller, R. B., Haase, N., Hjortrup, P. B., Møller, K., Lange, T., Wetterslev, J., Perner, A.

“…Background The Scandinavian Starch for Severe Sepsis/Septic Shock (6S) trial showed increased 90‐day mortality with hydroxyethyl starch (HES) 130/0.42 vs…”
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Lower vs Higher Fluid Volumes During Initial Management of Sepsis: A Systematic Review With Meta-Analysis and Trial Sequential Analysis by Meyhoff, Tine Sylvest, Møller, Morten Hylander, Hjortrup, Peter Buhl, Cronhjort, Maria, Perner, Anders, Wetterslev, Jørn

“…IV fluids are recommended during the initial management of sepsis, but the quality of evidence is low, and clinical equipoise exists. We aimed to assess…”
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Restriction of Intravenous Fluid in ICU Patients with Septic Shock by Meyhoff, Tine S., Hjortrup, Peter B., Wetterslev, Jørn, Sivapalan, Praleene, Laake, Jon H., Cronhjort, Maria, Jakob, Stephan M., Cecconi, Maurizio, Nalos, Marek, Ostermann, Marlies, Malbrain, Manu, Pettilä, Ville, Møller, Morten H., Kjær, Maj-Brit N., Lange, Theis, Overgaard-Steensen, Christian, Brand, Björn A., Winther-Olesen, Marie, White, Jonathan O., Quist, Lars, Westergaard, Bo, Jonsson, Andreas B., Hjortsø, Carl J.S., Meier, Nick, Jensen, Thomas S., Engstrøm, Janus, Nebrich, Lars, Andersen-Ranberg, Nina C., Jensen, Jacob V., Joseph, Neeliya A., Poulsen, Lone M., Herløv, Louise S., Sølling, Christoffer G., Pedersen, Susan K., Knudsen, Kurt K., Straarup, Therese S., Vang, Marianne L., Bundgaard, Helle, Rasmussen, Bodil S., Aagaard, Søren R., Hildebrandt, Thomas, Russell, Lene, Bestle, Morten H., Schønemann-Lund, Martin, Brøchner, Anne C., Elvander, Claes F., Hoffmann, Søren K.L., Rasmussen, Michael L., Martin, Yvonne K., Friberg, Fredrik F., Seter, Herman, Aslam, Tayyba N., Ådnøy, Sigrid, Seidel, Philipp, Strand, Kristian, Johnstad, Bror, Joelsson-Alm, Eva, Christensen, Jens, Ahlstedt, Christian, Pfortmueller, Carmen A., Siegemund, Martin, Greco, Massimiliano, Raděj, Jaroslav, Kříž, Miroslav, Gould, Doug W., Rowan, Kathy M., Mouncey, Paul R., Perner, Anders

“…In this trial, a restrictive approach to intravenous fluid administration in critically ill patients with septic shock did not reduce deaths at 90 days…”
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Lower versus Higher Hemoglobin Threshold for Transfusion in Septic Shock by Holst, Lars B, Haase, Nicolai, Wetterslev, Jørn, Wernerman, Jan, Guttormsen, Anne B, Karlsson, Sari, Johansson, Pär I, Åneman, Anders, Vang, Marianne L, Winding, Robert, Nebrich, Lars, Nibro, Helle L, Rasmussen, Bodil S, Lauridsen, Johnny R.M, Nielsen, Jane S, Oldner, Anders, Pettilä, Ville, Cronhjort, Maria B, Andersen, Lasse H, Pedersen, Ulf G, Reiter, Nanna, Wiis, Jørgen, White, Jonathan O, Russell, Lene, Thornberg, Klaus J, Hjortrup, Peter B, Müller, Rasmus G, Møller, Morten H, Steensen, Morten, Tjäder, Inga, Kilsand, Kristina, Odeberg-Wernerman, Suzanne, Sjøbø, Brit, Bundgaard, Helle, Thyø, Maria A, Lodahl, David, Mærkedahl, Rikke, Albeck, Carsten, Illum, Dorte, Kruse, Mary, Winkel, Per, Perner, Anders

“…A large Scandinavian randomized trial showed no important outcome differences between hemoglobin levels of 7 g per deciliter and 9 g per deciliter as…”
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Lower vs Higher Fluid Volumes in Adult Patients With Sepsis: An Updated Systematic Review With Meta-Analysis and Trial Sequential Analysis by Sivapalan, Praleene, Ellekjaer, Karen L, Jessen, Marie K, Meyhoff, Tine S, Cronhjort, Maria, Hjortrup, Peter B, Wetterslev, Jørn, Granholm, Anders, Møller, Morten H, Perner, Anders

“…IV fluids are recommended for adults with sepsis. However, the optimal strategy for IV fluid management in sepsis is unknown, and clinical equipoise exists. Do…”
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Immunoglobulin G for patients with necrotising soft tissue infection (INSTINCT): a randomised, blinded, placebo-controlled trial by Madsen, Martin B., Hjortrup, Peter B., Hansen, Marco B., Lange, Theis, Norrby-Teglund, Anna, Hyldegaard, Ole, Perner, Anders

“…Purpose The aim of the INSTINCT trial was to assess the effect of intravenous polyspecific immunoglobulin G (IVIG) compared with placebo on self-reported…”
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Low‐dose hydrocortisone in patients with COVID‐19 and severe hypoxia: The COVID STEROID randomised, placebo‐controlled trial by Munch, Marie Warrer, Meyhoff, Tine Sylvest, Helleberg, Marie, Kjær, Maj‐Brit Nørregaard, Granholm, Anders, Hjortsø, Carl Johan Steensen, Jensen, Thomas Steen, Møller, Morten Hylander, Hjortrup, Peter Buhl, Wetterslev, Mik, Vesterlund, Gitte Kingo, Russell, Lene, Jørgensen, Vibeke Lind, Kristiansen, Klaus Tjelle, Benfield, Thomas, Ulrik, Charlotte Suppli, Andreasen, Anne Sofie, Bestle, Morten Heiberg, Poulsen, Lone Musaeus, Hildebrandt, Thomas, Knudsen, Lene Surland, Møller, Anders, Sølling, Christoffer Grant, Brøchner, Anne Craveiro, Rasmussen, Bodil Steen, Nielsen, Henrik, Christensen, Steffen, Strøm, Thomas, Cronhjort, Maria, Wahlin, Rebecka Rubenson, Jakob, Stephan M., Cioccari, Luca, Venkatesh, Balasubramanian, Hammond, Naomi, Jha, Vivekanand, Myatra, Sheila Nainan, Jensen, Marie Qvist, Leistner, Jens Wolfgang, Mikkelsen, Vibe Sommer, Svenningsen, Jens S., Laursen, Signe Bjørn, Hatley, Emma Victoria, Kristensen, Camilla Meno, Al‐Alak, Ali, Clapp, Esben, Jonassen, Trine Bak, Bjerregaard, Caroline Løkke, Østerby, Niels Christian Haubjerg, Jespersen, Mette Mindedahl, Abou‐Kassem, Dalia, Lassen, Mathilde Languille, Zaabalawi, Reem, Daoud, Mohammed Mahmoud, Abdi, Suhayb, Meier, Nick, Cour, Kirstine, Derby, Cecilie Bauer, Damlund, Birka Ravnholt, Laigaard, Jens, Andersen, Lene Lund, Mikkelsen, Johan, Jensen, Jeppe Lundholm Stadarfeld, Rasmussen, Anders Hørby, Arnerlöv, Emil, Lykke, Mathilde, Holst‐Hansen, Mikkel Zacharias Bystrup, Tøstesen, Boris Wied, Schwab, Janne, Madsen, Emilie Kabel, Gluud, Christian, Lange, Theis, Perner, Anders

“…Background In the early phase of the pandemic, some guidelines recommended the use of corticosteroids for critically ill patients with COVID‐19, whereas others…”
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Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock by Kjær, Maj-Brit Nørregaard, Meyhoff, Tine Sylvest, Sivapalan, Praleene, Granholm, Anders, Hjortrup, Peter Buhl, Madsen, Martin Bruun, Møller, Morten Hylander, Egerod, Ingrid, Wetterslev, Jørn, Lange, Theis, Cronhjort, Maria, Laake, Jon Henrik, Jakob, Stephan M., Nalos, Marek, Ostermann, Marlies, Gould, Doug, Cecconi, Maurizio, Malbrain, Manu L. N. G., Ahlstedt, Christian, Kiel, Louise Bendix, Bestle, Morten H., Nebrich, Lars, Hildebrandt, Thomas, Russell, Lene, Vang, Marianne, Rasmussen, Michael Lindhart, Sølling, Christoffer, Brøchner, Anne Craveiro, Krag, Mette, Pfortmueller, Carmen, Kriz, Miroslav, Siegemund, Martin, Albano, Giovanni, Aagaard, Søren Rosborg, Bundgaard, Helle, Crone, Vera, Wichmann, Sine, Johnstad, Bror, Martin, Yvonne Karin, Seidel, Philipp, Mårtensson, Johan, Hollenberg, Jacob, Wistrand, Mats, Donati, Abele, Barbara, Enrico, Karvunidis, Thomas, Hollinger, Alexa, Carsetti, Andrea, Lumlertgul, Nuttha, Joelsson-Alm, Eva, Lambiris, Nikolas, Aslam, Tayyba Naz, Friberg, Fredrik Femtehjell, Vesterlund, Gitte Kingo, Mortensen, Camilla Bekker, Vestergaard, Stine Rom, Caspersen, Sidsel Fjordbak, Jensen, Diana Bertelsen, Borup, Morten, Rasmussen, Bodil Steen, Perner, Anders

“…Purpose To assess long-term outcomes of restrictive versus standard intravenous (IV) fluid therapy in adult intensive care unit (ICU) patients with septic…”
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Randomized Controlled Trials on Lower vs Higher Fluid Volumes During Initial Management of Sepsis Are Very Fragile Reply by Meyhoff, TS, Moller, MH, Hjortrup, PB, Cronhjort, M, Perner, A, Wetterslev, J

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Albumin use in patients with septic shock—Post‐hoc analyses of an international randomised fluid trial by Meyhoff, Tine Sylvest, Granholm, Anders, Hjortrup, Peter Buhl, Sivapalan, Praleene, Lange, Theis, Laake, Jon Henrik, Cronhjort, Maria, Jakob, Stephan M., Cecconi, Maurizio, Nalos, Marek, Ostermann, Marlies, Malbrain, Manu L. N. G., Møller, Morten Hylander, Perner, Anders

“…Background Albumin administration is suggested in patients with sepsis and septic shock who have received large volumes of crystalloids. Given lack of firm…”
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Albumin administration in septic shock—Protocol for post‐hoc analyses of data from a multicentre RCT by Meyhoff, Tine Sylvest, Granholm, Anders, Hjortrup, Peter Buhl, Sivapalan, Praleene, Lange, Theis, Laake, Jon Henrik, Cronhjort, Maria, Jakob, Stephan M., Cecconi, Maurizio, Nalos, Marek, Ostermann, Marlies, Malbrain, Manu L. N. G., Møller, Morten Hylander, Perner, Anders

“…Background Intravenous (IV) albumin is suggested for patients with septic shock who have received large amounts of IV crystalloids; a conditional…”
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Restrictive versus standard IV fluid therapy in adult ICU patients with septic shock—Bayesian analyses of the CLASSIC trial by Sivapalan, Praleene, Meyhoff, Tine Sylvest, Hjortrup, Peter Buhl, Lange, Theis, Kaas‐Hansen, Benjamin Skov, Kjær, Maj‐Brit N., Laake, Jon Henrik, Cronhjort, Maria, Jakob, Stephan M., Cecconi, Maurizio, Nalos, Marek, Ostermann, Marlies, Malbrain, Manu L. N. G., Møller, Morten Hylander, Perner, Anders, Granholm, Anders

“…Background The CLASSIC trial assessed the effects of restrictive versus standard intravenous (IV) fluid therapy in adult intensive care unit (ICU) patients…”
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Effects of IV fluid restriction according to site‐specific intensity of standard fluid treatment—protocol by Sivapalan, Praleene, Kaas‐Hansen, Benjamin Skov, Meyhoff, Tine Sylvest, Hjortrup, Peter Buhl, Kjær, Maj‐Brit N., Laake, Jon Henrik, Cronhjort, Maria, Jakob, Stephan M., Cecconi, Maurizio, Nalos, Marek, Ostermann, Marlies, Malbrain, Manu L. N. G., Møller, Morten Hylander, Perner, Anders, Granholm, Anders

“…Background Variation in usual practice in fluid trials assessing lower versus higher volumes may affect overall comparisons. To address this, we will evaluate…”
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