Search Results - "Hjorth, S."

The orphan receptor GPR55 is a novel cannabinoid receptor by Ryberg, E, Larsson, N, Sjögren, S, Hjorth, S, Hermansson, N‐O, Leonova, J, Elebring, T, Nilsson, K, Drmota, T, Greasley, P J

“…Background: The endocannabinoid system functions through two well characterized receptor systems, the CB1 and CB2 receptors. Work by a number of groups in…”
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Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans by Baumgartner, R., Berg, M., Matic, L., Polyzos, K. P., Forteza, M. J., Hjorth, S. A., Schwartz, T. W., Paulsson‐Berne, G., Hansson, G. K., Hedin, U., Ketelhuth, D. F. J.

“…Background The metabolism of tryptophan (Trp) along the kynurenine pathway has been shown to carry strong immunoregulatory properties. Several experimental…”
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A systems biology approach to understand gut microbiota and host metabolism in morbid obesity: design of the BARIA Longitudinal Cohort Study by Van Olden, C. C., Van de Laar, A. W., Meijnikman, A. S., Aydin, O., Van Olst, N., Hoozemans, J. B., De Brauw, L. M., Bruin, S. C., Acherman, Y. I. Z., Verheij, J., Pyykkö, J. E., Hagedoorn, M., Sanderman, R., Bosma, N. C., Tremaroli, V., Lundqvist, A., Olofsson, L. E., Herrema, H., Lappa, D., Hjorth, S., Nielsen, J., Schwartz, T., Groen, A. K., Nieuwdorp, M., Bäckhed, F., Gerdes, V. E. A.

“…Introduction Prevalence of obesity and associated diseases, including type 2 diabetes mellitus, dyslipidaemia and non‐alcoholic fatty liver disease (NAFLD),…”
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Self-organized metabotyping of obese individuals identifies clusters responding differently to bariatric surgery by Lappa, Dimitra, Meijnikman, Abraham S, Krautkramer, Kimberly A, Olsson, Lisa M, Aydin, Ömrüm, Van Rijswijk, Anne-Sophie, Acherman, Yair I Z, De Brauw, Maurits L, Tremaroli, Valentina, Olofsson, Louise E, Lundqvist, Annika, Hjorth, Siv A, Ji, Boyang, Gerdes, Victor E A, Groen, Albert K, Schwartz, Thue W, Nieuwdorp, Max, Bäckhed, Fredrik, Nielsen, Jens

“…Weight loss through bariatric surgery is efficient for treatment or prevention of obesity related diseases such as type 2 diabetes and cardiovascular disease…”
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(3 S )‐3‐(2,3‐difluorophenyl)‐3‐methoxypyrrolidine (IRL752) —a Novel Cortical-Preferring Catecholamine Transmission- and Cognition-Promoting Agent by Hjorth, S., Waters, S., Waters, N., Tedroff, J., Svensson, P., Fagerberg, A., Edling, M., Svanberg, B., Ljung, E., Gunnergren, J., McLean, S.L., Grayson, B., Idris, N.F., Neill, J.C., Sonesson, C.

“…Here we describe for the first time the distinctive pharmacological profile for (35)-3-(2,3-difluorophenyI)-3-nnethoxypyrrolidine (IRL752), a new…”
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Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration by Mikkelsen, Randi Bonke, Arora, Tulika, Trošt, Kajetan, Dmytriyeva, Oksana, Jensen, Sune Kjærsgaard, Meijnikman, Abraham Stijn, Olofsson, Louise Elisabeth, Lappa, Dimitra, Aydin, Ömrüm, Nielsen, Jens, Gerdes, Victor, Moritz, Thomas, van de Laar, Arnold, de Brauw, Maurits, Nieuwdorp, Max, Hjorth, Siv Annegrethe, Schwartz, Thue Walter, Bäckhed, Fredrik

“…Obesity and diabetes are associated with inflammation and altered plasma levels of several metabolites, which may be involved in disease progression. Some…”
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The selective 5-hydroxytryptamine 1A antagonist, AZD7371 [3(R)-(N,N-dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide (R,R)-tartrate monohydrate] (robalzotan tartrate monohydrate), inhibits visceral pain-related visceromotor, but not autonomic cardiovascular, responses to colorectal distension in rats by Lindström, E, Ravnefjord, A, Brusberg, M, Hjorth, S, Larsson, H, Martinez, V

“…5-Hydroxytryptamine 1A (5-HT(1A)) receptors have been suggested as a target for the treatment of irritable bowel syndrome (IBS). A recent clinical trial…”
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Serotonin autoreceptor function and antidepressant drug action by Hjorth, S., Bengtsson, H. J., Kullberg, A., Carlzon, D., Peilot, H., Auerbach, S. B.

“…This article briefly summarizes, within the context of a brief review of the relevant literature, the outcome of our recent rat microdialysis studies on (1)…”
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Mutational Evidence for a Common κ Antagonist Binding Pocket in the Wild-Type κ and Mutant μ[K303E] Opioid Receptors by Jones, Robert M, Hjorth, Siv A, Schwartz, Thue W, Portoghese, Philip S

“…The selectivity of the prototypical Kappa opioid receptor (OP sub(2)) antagonist norbinaltorphimine (nor-BNI, 1) has been attributed to the presence of an…”
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A new mathematical model to predict cavern diameters in highly shear thinning, power law liquids using axial flow impellers by Amanullah, A., Hjorth, S.A., Nienow, A.W.

“…An axial force model is described for predicting cavern diameters in highly shear thinning liquids using axial flow impellers. The model has been verified…”
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Effects of selective serotonin and serotonin/noradrenaline reuptake inhibitors on extracellular serotonin in rat diencephalon and frontal cortex by Felton, Tracy M, Kang, Tommy B, Hjorth, Stephan, Auerbach, Sidney B

“…Some clinical reports suggest that tricyclic antidepressants which block both noradrenaline and serotonin (5-HT) reuptake (SNRIs) are more effective than…”
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Phenotypic and genotypic characterization of prolyliminopeptidase-negative Neisseria gonorrhoeae isolates in Denmark by FJELDSØE-NIELSEN, H, UNEMO, M, FREDLUND, H, HJORTH, S. V, BERTHELSEN, L. M, PALMER, H. M, FRIIS-MØLLER, A

“…In the study presented here 26 recent Danish clinical isolates of prolyliminopeptidase (PIP)-negative Neisseria gonorrhoeae were phenotypically and…”
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Hypothermia in the rat induced by the potent serotoninergic agent 8-OH-DPAT by HJORTH, S

“…The potent, centrally acting 5-HT receptor agonist 8-OH-DPAT was shown to induce a clearcut hypothermic response in naive and PCPA-pretreated conscious rats,…”
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The 5-HT1A receptor agonist, 8-OH-DPAT, preferentially activates cell body 5-HT autoreceptors in rat brain in vivo by Hjorth, S., Magnusson, T.

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5-HT1A autoreceptors and the mode of action of selective serotonin reuptake inhibitors (SSRI) by HJORTH, S, AUERBACH, S. B

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Lack of 5-HT1A autoreceptor desensitization following chronic citalopram treatment, as determined by in vivo microdialysis by Hjorth, S, Auerbach, S B

“…Electrophysiological studies suggest that 5-HT autoreceptor desensitization may be responsible for the delayed clinical efficacy of some antidepressant drugs,…”
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Autoreceptor antagonists enhance the effect of the reuptake inhibitor citalopram on extracellular 5-HT: this effect persists after repeated citalopram treatment by Gundlah, C, Hjorth, S, Auerbach, S B

“…The effect of repeated administration of the reuptake inhibitor citalopram (10 mg/kg s.c., b.i.d. for 14 days) or saline on extracellular 5-hydroxytryptamine…”
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Studies on the role of 5-HT1A autoreceptors and α1-adrenoceptors in the inhibition of 5-HT release. I: BMY7378 and prazosin by HJORTH, S, BENGTSSON, H. J, MILANO, S, LUNDBERG, J. F, SHARP, T

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Differentiation Between Binding Sites for Angiotensin II and Nonpeptide Antagonists on the Angiotensin II Type 1 Receptors by Schambye, Hans T., Hjorth, Siv A., Bergsma, Derk J., Sathe, Ganesh, Schwartz, Thue W.

“…To characterize binding sites for nonpeptide angiotensin antagonists on the human angiotensin II receptor type 1 (AT1receptor) we have systematically exchanged…”
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Binding of Norbinaltorphimine (norBNI) Congeners to Wild-Type and Mutant Mu and Kappa Opioid Receptors:  Molecular Recognition Loci for the Pharmacophore and Address Components of Kappa Antagonists by Larson, Dennis L, Jones, Robert M, Hjorth, Siv A, Schwartz, Thue W, Portoghese, Philip S

“…Molecular modifications of both the kappa opioid antagonist norbinaltorphimine (norBNI, 1) and the kappa receptor have provided evidence that the selectivity…”
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