Search Results - "Hjorth, S A"

Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans by Baumgartner, R., Berg, M., Matic, L., Polyzos, K. P., Forteza, M. J., Hjorth, S. A., Schwartz, T. W., Paulsson‐Berne, G., Hansson, G. K., Hedin, U., Ketelhuth, D. F. J.

“…Background The metabolism of tryptophan (Trp) along the kynurenine pathway has been shown to carry strong immunoregulatory properties. Several experimental…”
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Mutational Evidence for a Common κ Antagonist Binding Pocket in the Wild-Type κ and Mutant μ[K303E] Opioid Receptors by Jones, Robert M, Hjorth, Siv A, Schwartz, Thue W, Portoghese, Philip S

“…The selectivity of the prototypical Kappa opioid receptor (OP sub(2)) antagonist norbinaltorphimine (nor-BNI, 1) has been attributed to the presence of an…”
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A new mathematical model to predict cavern diameters in highly shear thinning, power law liquids using axial flow impellers by Amanullah, A., Hjorth, S.A., Nienow, A.W.

“…An axial force model is described for predicting cavern diameters in highly shear thinning liquids using axial flow impellers. The model has been verified…”
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Differentiation Between Binding Sites for Angiotensin II and Nonpeptide Antagonists on the Angiotensin II Type 1 Receptors by Schambye, Hans T., Hjorth, Siv A., Bergsma, Derk J., Sathe, Ganesh, Schwartz, Thue W.

“…To characterize binding sites for nonpeptide angiotensin antagonists on the human angiotensin II receptor type 1 (AT1receptor) we have systematically exchanged…”
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Analysis of selective binding epitopes for the kappa-opioid receptor antagonist nor-binaltorphimine by Hjorth, S A, Thirstrup, K, Grandy, D K, Schwartz, T W

“…The structural determinants for the selective binding of the nonpeptide opioid receptor antagonist nor-binaltorphimine (nor-BNI) to the kappa-opioid receptor…”
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Binding of Norbinaltorphimine (norBNI) Congeners to Wild-Type and Mutant Mu and Kappa Opioid Receptors:  Molecular Recognition Loci for the Pharmacophore and Address Components of Kappa Antagonists by Larson, Dennis L, Jones, Robert M, Hjorth, Siv A, Schwartz, Thue W, Portoghese, Philip S

“…Molecular modifications of both the kappa opioid antagonist norbinaltorphimine (norBNI, 1) and the kappa receptor have provided evidence that the selectivity…”
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Glucagon and glucagon-like peptide 1: selective receptor recognition via distinct peptide epitopes by Hjorth, S A, Adelhorst, K, Pedersen, B B, Kirk, O, Schwartz, T W

“…Glucagon and glucagon-like peptide 1 (GLP-1) are homologous peptide hormones that are recognized by likewise homologous, but highly selective receptors…”
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Radioligand-dependent discrepancy in agonist affinities enhanced by mutations in the kappa-opioid receptor by Hjorth, S A, Thirstrup, K, Schwartz, T W

“…A series of kappa/mu receptor chimeras and a number of kappa receptors substituted in the second transmembrane segment (TM-II) were investigated using as…”
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Cavern Sizes Generated in Highly Shear Thinning Viscous Fluids by SCABA 3SHP1 Impellers by Amanullah, A., Hjorth, S.A., Nienow, A.W.

“…The dimensions of caverns formed in highly shear thinning Carbopol solutions using axial flow SCABA 3SHP1 impellers with D/T ratios of 0.33, 0.44 and 0.49 at…”
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Identification of peptide binding residues in the extracellular domains of the AT1 receptor by Hjorth, S A, Schambye, H T, Greenlee, W J, Schwartz, T W

“…To locate essential determinants for angiotensin II binding, we have performed a systematic mutational analysis of the exterior domain of the AT1 receptor…”
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Glucagon and GLP-1 receptors: lessons from chimeric ligands and receptors by Hjorth, S A, Schwartz, T W

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Interaction between the nonpeptide angiotensin antagonist SKF-108,566 and histidine 256 (HisVI:16) of the angiotensin type 1 receptor by Schambye, H T, Hjorth, S A, Weinstock, J, Schwartz, T W

“…His256 (HisVI:16) of transmembrane segment (TM)-VI of the rat angiotensin type 1 (AT1) receptor was targeted for mutagenesis to investigate its potential…”
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Mutations along transmembrane segment II of the NK-1 receptor affect substance P competition with non-peptide antagonists but not substance P binding by Rosenkilde, M M, Cahir, M, Gether, U, Hjorth, S A, Schwartz, T W

“…Mutational analysis of the NK-1 receptor indicates that residues involved in non-peptide antagonist binding cluster around the outer portion of transmembrane…”
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Constitutive Activation of Tethered-Peptide/Corticotropin-Releasing Factor Receptor Chimeras by Nielsen, S M, Nielsen, L Z, Hjorth, S A, Perrin, M H, Vale, W W

“…Constitutive activity, or ligand-independent activity, of mutant G protein-coupled receptors (GPCRs) has been described extensively and implicated in the…”
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Constitutive Activity of Glucagon Receptor Mutants by Hjorth, Siv A, Ørskov, Cathrine, Schwartz, Thue W

“…Increased constitutive activity has been observed in the PTH receptor in association with naturally occurring mutations of two residues that are conserved…”
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Construction of a high affinity zinc switch in the kappa-opioid receptor by Thirstrup, K, Elling, C E, Hjorth, S A, Schwartz, T W

“…Very limited structural information is available concerning the superfamily of G-protein-coupled receptors with their seven-transmembrane segments. Recently a…”
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Steric hindrance mutagenesis versus alanine scan in mapping of ligand binding sites in the tachykinin NK1 receptor by Holst, B, Zoffmann, S, Elling, C E, Hjorth, S A, Schwartz, T W

“…Residues in transmembrane domain (TM)-III, TM-V, TM-VI, and TM-VII believed to be facing the deep part of the presumed main ligand-binding pocket of the NK1…”
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Mutational analysis of the interaction of the N- and C-terminal ends of angiotensin II with the rat AT(1A) receptor by Costa-Neto, C M, Miyakawa, A A, Oliveira, L, Hjorth, S A, Schwartz, T W, Paiva, A C

“…1. The role of different residues of the rat AT(1A) receptor in the interaction with the N- and C-terminal ends of angiotensin II (AngII) was studied by…”
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Self-organized metabotyping of obese individuals identifies clusters responding differently to bariatric surgery by Lappa, Dimitra, Meijnikman, Abraham S, Krautkramer, Kimberly A, Olsson, Lisa M, Aydin, Ömrüm, Van Rijswijk, Anne-Sophie, Acherman, Yair I Z, De Brauw, Maurits L, Tremaroli, Valentina, Olofsson, Louise E, Lundqvist, Annika, Hjorth, Siv A, Ji, Boyang, Gerdes, Victor E A, Groen, Albert K, Schwartz, Thue W, Nieuwdorp, Max, Bäckhed, Fredrik, Nielsen, Jens

“…Weight loss through bariatric surgery is efficient for treatment or prevention of obesity related diseases such as type 2 diabetes and cardiovascular disease…”
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Ligand binding pocket of the human somatostatin receptor 5: mutational analysis of the extracellular domains by Greenwood, M T, Hukovic, N, Kumar, U, Panetta, R, Hjorth, S A, Srikant, C B, Patel, Y C

“…The ligand binding domain of G protein-coupled receptors for peptide ligands consists of a pocket formed by extracellular and transmembrane domain (TM)…”
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