Search Results - "Hjortø, Gertrud Malene"

Dendritic Cells and CCR7 Expression: An Important Factor for Autoimmune Diseases, Chronic Inflammation, and Cancer by Brandum, Emma Probst, Jørgensen, Astrid Sissel, Rosenkilde, Mette Marie, Hjortø, Gertrud Malene

“…Chemotactic cytokines—chemokines—control immune cell migration in the process of initiation and resolution of inflammatory conditions as part of the body’s…”
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Chemokine Receptor N-Terminus Charge Dictates Reliance on Post-Translational Modifications for Effective Ligand Capture and Following Boosting by Defense Peptides by Xu, Ting, Schou, Anne Sophie, Lackman, Jarkko J, Barrio-Calvo, Marina, Verhallen, Lisa, Goth, Christoffer Knak, Jensen, Benjamin Anderschou Holbech, Veldkamp, Christopher T, Volkman, Brian F, Peterson, Francis C, Hjortø, Gertrud Malene

“…The chemokine receptors CCR1 and CCR5 display overlapping expression patterns and ligand dependency. Here we find that ligand activation of CCR5, not CCR1, is…”
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Selective Boosting of CCR7-Acting Chemokines; Short Peptides Boost Chemokines with Short Basic Tails, Longer Peptides Boost Chemokines with Long Basic Tails by Brandum, Emma Probst, Jørgensen, Astrid Sissel, Calvo, Marina Barrio, Spiess, Katja, Peterson, Francis C, Yang, Zhang, Volkman, Brian F, Veldkamp, Christopher T, Rosenkilde, Mette Marie, Goth, Christoffer Knak, Hjortø, Gertrud Malene

“…The chemokine receptor CCR7 and its ligands CCL19 and CCL21 regulate the lymph node homing of dendritic cells and naïve T-cells and the following induction of…”
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In-chip fabrication of free-form 3D constructs for directed cell migration analysis by Olsen, Mark Holm, Hjortø, Gertrud Malene, Hansen, Morten, Met, Özcan, Svane, Inge Marie, Larsen, Niels B

“…Free-form constructs with three-dimensional (3D) microporosity were fabricated by two-photon polymerization inside the closed microchannel of an…”
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Discovery and Characterization of Biased Allosteric Agonists of the Chemokine Receptor CXCR3 by Milanos, Lampros, Brox, Regine, Frank, Theresa, Poklukar, Gašper, Palmisano, Ralf, Waibel, Reiner, Einsiedel, Jürgen, Dürr, Maximilian, Ivanović-Burmazović, Ivana, Larsen, Olav, Hjortø, Gertrud Malene, Rosenkilde, Mette Marie, Tschammer, Nuska

“…In this work we report a design, synthesis, and detailed functional characterization of unique strongly biased allosteric agonists of CXCR3 that contain…”
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Three-Dimensional Explant Platform for Studies on Choroid Plexus Epithelium by Petersen, Natalia, Torz, Lola, Jensen, Kristian H Reveles, Hjortø, Gertrud Malene, Spiess, Katja, Rosenkilde, Mette Marie

“…The choroid plexus (CP) plays a major role in controlling the entry of substances and immune cells into the brain as it forms the blood-cerebrospinal fluid…”
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Comparison of clinical grade type 1 polarized and standard matured dendritic cells for cancer immunotherapy by Hansen, Morten, Hjortø, Gertrud Malene, Donia, Marco, Met, Özcan, Larsen, Niels Bent, Andersen, Mads Hald, thor Straten, Per, Svane, Inge Marie

“…Highlights ► Standard and type 1 polarized DCs were compared for use in cancer immunotherapy. ► Type 1 polarized DCs (αDC1 and mDC) induced superior T cell…”
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GPR183 Is Dispensable for B1 Cell Accumulation and Function, but Affects B2 Cell Abundance, in the Omentum and Peritoneal Cavity by Barington, Line, Christensen, Liv von Voss, Pedersen, Kristian Kåber, Niss Arfelt, Kristine, Roumain, Martin, Jensen, Kristian Høj Reveles, Kjær, Viktoria Madeline Skovgaard, Daugvilaite, Viktorija, Kearney, John F, Christensen, Jan Pravsgaard, Hjortø, Gertrud Malene, Muccioli, Giulio G, Holst, Peter Johannes, Rosenkilde, Mette Marie

“…B1 cells constitute a specialized subset of B cells, best characterized in mice, which is abundant in body cavities, including the peritoneal cavity. Through…”
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Probing Biased Signaling in Chemokine Receptors by Amarandi, Roxana-Maria, Hjortø, Gertrud Malene, Rosenkilde, Mette Marie, Karlshøj, Stefanie

“…The chemokine system mediates leukocyte migration during homeostatic and inflammatory processes. Traditionally, it is described as redundant and promiscuous,…”
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The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus by Jørgensen, Astrid Sissel, Brandum, Emma Probst, Mikkelsen, Jeppe Malthe, Orfin, Klaudia A., Boilesen, Ditte Rahbæk, Egerod, Kristoffer Lihme, Moussouras, Natasha A., Vilhardt, Frederik, Kalinski, Pawel, Basse, Per, Chen, Yen-Hsi, Yang, Zhang, Dwinell, Michael B., Volkman, Brian F., Veldkamp, Christopher T., Holst, Peter Johannes, Lahl, Katharina, Goth, Christoffer Knak, Rosenkilde, Mette Marie, Hjortø, Gertrud Malene

“…The endogenous chemokines CCL19 and CCL21 signal via their common receptor CCR7. CCL21 is the main lymph node homing chemokine, but a weak chemo-attractant…”
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Autocrine CCL19 blocks dendritic cell migration toward weak gradients of CCL21 by Hansen, Morten, Met, Özcan, Larsen, Niels Bent, Rosenkilde, Mette Marie, Andersen, Mads Hald, Svane, Inge Marie, Hjortø, Gertrud Malene

“…Abstract Background aims Maturation of dendritic cells (DCs) induces their homing from peripheral to lymphatic tissues guided by CCL21. However, in vitro…”
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Confinement dependent chemotaxis in two-photon polymerized linear migration constructs with highly definable concentration gradients by Hjortø, Gertrud Malene, Olsen, Mark Holm, Svane, Inge Marie, Larsen, Niels B.

“…Dendritic cell chemotaxis is known to follow chemoattractant concentration gradients through tissue of heterogeneous pore sizes, but the dependence of…”
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Increased adsorption of histidine-tagged proteins onto tissue culture polystyrene by Holmberg, Maria, Hansen, Thomas Steen, Lind, Johan Ulrik, Hjortø, Gertrud Malene

“…[Display omitted] ► Adding a histidine tag to a protein can have a high effect on the adsorption characteristics of the protein. ► Dependent on the pI value of…”
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Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines by Hjortø, Gertrud M, Larsen, Olav, Steen, Anne, Daugvilaite, Viktorija, Berg, Christian, Fares, Suzan, Hansen, Morten, Ali, Simi, Rosenkilde, Mette M

“…The CCR7 ligands CCL19 and CCL21 are increasingly recognized as functionally different (biased). Using mature human dendritic cells (DCs), we show that CCL19…”
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