Search Results - "Hjerling Leffler, J."

Maternal thyroid hormone is required for parvalbumin neurone development in the anterior hypothalamic area by Harder, L., Dudazy‐Gralla, S., Müller‐Fielitz, H., Hjerling Leffler, J., Vennström, B., Heuer, H., Mittag, J.

“…Thyroid hormone (TH) is crucial for brain development and function. This becomes most evident in untreated congenital hypothyroidism, leading to irreversible…”
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Ghrelin suppresses insulin secretion in human islets and type 2 diabetes patients have diminished islet ghrelin cell number and lower plasma ghrelin levels by Lindqvist, A., Shcherbina, L., Prasad, R.B., Miskelly, M.G., Abels, M., Martínez-Lopéz, J.A., Fred, R.G., Nergård, B.J., Hedenbro, J., Groop, L., Hjerling-Leffler, J., Wierup, N.

“…It is not known how ghrelin affects insulin secretion in human islets from patients with type 2 diabetes (T2D) or whether islet ghrelin expression or…”
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Novel Striatal GABAergic Interneuron Populations Labeled in the 5HT3a(EGFP) Mouse by Muñoz-Manchado, A B, Foldi, C, Szydlowski, S, Sjulson, L, Farries, M, Wilson, C, Silberberg, G, Hjerling-Leffler, J

“…Histological and morphological studies indicate that approximately 5% of striatal neurons are cholinergic or γ-aminobutyric acidergic (GABAergic) interneurons…”
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Emergence of Functional Sensory Subtypes as Defined by Transient Receptor Potential Channel Expression by Hjerling-Leffler, Jens, AlQatari, Mona, Ernfors, Patrik, Koltzenburg, Martin

“…The existence of heterogeneous populations of dorsal root ganglion (DRG) neurons conveying different somatosensory information is the basis for the perception…”
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Novel Striatal GABAergic Interneuron Populations Labeled in the 5HT3a EGFP Mouse by Muñoz-Manchado, A.B., Foldi, C., Szydlowski, S., Sjulson, L., Farries, M., Wilson, C., Silberberg, G., Hjerling-Leffler, J.

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Environmental enrichment and the brain by Mohammed, A H, Zhu, S W, Darmopil, S, Hjerling-Leffler, J, Ernfors, P, Winblad, B, Diamond, M C, Eriksson, P S, Bogdanovic, N

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26 GENE TARGETING WITH RNAI IN PRIMARY SENSORY NEURONS: FROM SIRNA DESIGN TO PHYSIOLOGICAL EFFECT by Usoskin, D., Aquino, J., Hjerling-Leffler, J., Maxvall, I., Ernfors, P.

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Molecular Architecture of the Mouse Nervous System by Zeisel, Amit, Hochgerner, Hannah, Lönnerberg, Peter, Johnsson, Anna, Memic, Fatima, van der Zwan, Job, Häring, Martin, Braun, Emelie, Borm, Lars E., La Manno, Gioele, Codeluppi, Simone, Furlan, Alessandro, Lee, Kawai, Skene, Nathan, Harris, Kenneth D., Hjerling-Leffler, Jens, Arenas, Ernest, Ernfors, Patrik, Marklund, Ulrika, Linnarsson, Sten

“…The mammalian nervous system executes complex behaviors controlled by specialized, precisely positioned, and interacting cell types. Here, we used RNA…”
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Disentangling neural cell diversity using single-cell transcriptomics by Poulin, Jean-Francois, Tasic, Bosiljka, Hjerling-Leffler, Jens, Trimarchi, Jeffrey M, Awatramani, Rajeshwar

“…Although single-cell gene expression profiling has been possible for the past two decades, a number of recent technological advances in microfluidic and…”
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Probabilistic cell typing enables fine mapping of closely related cell types in situ by Qian, Xiaoyan, Harris, Kenneth D., Hauling, Thomas, Nicoloutsopoulos, Dimitris, Muñoz-Manchado, Ana B., Skene, Nathan, Hjerling-Leffler, Jens, Nilsson, Mats

“…Understanding the function of a tissue requires knowing the spatial organization of its constituent cell types. In the cerebral cortex, single-cell RNA…”
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Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing by Usoskin, Dmitry, Furlan, Alessandro, Islam, Saiful, Abdo, Hind, Lönnerberg, Peter, Lou, Daohua, Hjerling-Leffler, Jens, Haeggström, Jesper, Kharchenko, Olga, Kharchenko, Peter V, Linnarsson, Sten, Ernfors, Patrik

“…Based on single cell RNA-sequencing of 622 adult mouse sensory neurons, Usoskin et al . performed unbiased classification to identify the cellular and…”
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Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons by Rudy, Bernardo, Fishell, Gordon, Lee, SooHyun, Hjerling‐Leffler, Jens

“…An understanding of the diversity of cortical GABAergic interneurons is critical to understand the function of the cerebral cortex. Recent data suggest that…”
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Specialized cutaneous Schwann cells initiate pain sensation by Abdo, Hind, Calvo-Enrique, Laura, Lopez, Jose Martinez, Song, Jianren, Zhang, Ming-Dong, Usoskin, Dmitry, El Manira, Abdeljabbar, Adameyko, Igor, Hjerling-Leffler, Jens, Ernfors, Patrik

“…An essential prerequisite for the survival of an organism is the ability to detect and respond to aversive stimuli. Current belief is that noxious stimuli…”
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The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors by Lee, SooHyun, Hjerling-Leffler, Jens, Zagha, Edward, Fishell, Gord, Rudy, Bernardo

“…A highly diverse population of neocortical GABAergic inhibitory interneurons has been implicated in multiple functions in information processing within…”
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Schizophrenia genomics: genetic complexity and functional insights by Sullivan, Patrick F., Yao, Shuyang, Hjerling-Leffler, Jens

“…Determining the causes of schizophrenia has been a notoriously intractable problem, resistant to a multitude of investigative approaches over centuries. In…”
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Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics by Harris, Kenneth D, Hochgerner, Hannah, Skene, Nathan G, Magno, Lorenza, Katona, Linda, Bengtsson Gonzales, Carolina, Somogyi, Peter, Kessaris, Nicoletta, Linnarsson, Sten, Hjerling-Leffler, Jens

“…Understanding any brain circuit will require a categorization of its constituent neurons. In hippocampal area CA1, at least 23 classes of GABAergic neuron have…”
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Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development by Marques, Sueli, van Bruggen, David, Vanichkina, Darya Pavlovna, Floriddia, Elisa Mariagrazia, Munguba, Hermany, Väremo, Leif, Giacomello, Stefania, Falcão, Ana Mendanha, Meijer, Mandy, Björklund, Åsa Kristina, Hjerling-Leffler, Jens, Taft, Ryan James, Castelo-Branco, Gonçalo

“…Pdgfra+ oligodendrocyte precursor cells (OPCs) arise in distinct specification waves during embryogenesis in the central nervous system (CNS). It is unclear…”
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Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System by Memic, Fatima, Knoflach, Viktoria, Morarach, Khomgrit, Sadler, Rebecca, Laranjeira, Catia, Hjerling-Leffler, Jens, Sundström, Erik, Pachnis, Vassilis, Marklund, Ulrika

“…The enteric nervous system (ENS) regulates gastrointestinal function via different subtypes of neurons, organized into fine-tuned neural circuits. It is not…”
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Diversity of Interneurons in the Dorsal Striatum Revealed by Single-Cell RNA Sequencing and PatchSeq by Muñoz-Manchado, Ana B., Bengtsson Gonzales, Carolina, Zeisel, Amit, Munguba, Hermany, Bekkouche, Bo, Skene, Nathan G., Lönnerberg, Peter, Ryge, Jesper, Harris, Kenneth D., Linnarsson, Sten, Hjerling-Leffler, Jens

“…Striatal locally projecting neurons, or interneurons, act on nearby circuits and shape functional output to the rest of the basal ganglia. We performed…”
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Genetic Fate Mapping Reveals That the Caudal Ganglionic Eminence Produces a Large and Diverse Population of Superficial Cortical Interneurons by Miyoshi, Goichi, Hjerling-Leffler, Jens, Karayannis, Theofanis, Sousa, Vitor H, Butt, Simon J. B, Battiste, James, Johnson, Jane E, Machold, Robert P, Fishell, Gord

“…By combining an inducible genetic fate mapping strategy with electrophysiological analysis, we have systematically characterized the populations of cortical…”
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