Search Results - "Hjelle, Jerry J."

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    Metabolism of malondialdehyde by rat liver aldehyde dehydrogenase by Hjelle, J J, Petersen, D R

    Published in Toxicology and applied pharmacology (01-08-1983)
    “…Mammalian liver contains a group of pyridine nucleotide linked aldehyde dehydrogenases [E.C. 1.2.1.3] which are present in high specific activity and possess…”
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  4. 4

    Comparison of the effects of ethanol and 4-methylpyrazole on the pharmacokinetics and toxicity of ethylene glycol in the dog by Grauer, G F, Thrall, M A, Henre, B A, Hjelle, J J

    Published in Toxicology letters (01-02-1987)
    “…The purpose of this investigation was to compare the effects of ethanol and 4-methylpyrazole (4MP) on the toxicity and pharmacokinetics of ethylene glycol (EG)…”
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  5. 5

    Transient induction of hepatic metallothionein following oral ethanol administration by Waalkes, M P, Hjelle, J J, Klaassen, C D

    Published in Toxicology and applied pharmacology (30-06-1984)
    “…Chronic ethanol ingestion has been associated with alterations of zinc homeostasis. Various treatments that alter zinc disposition induce hepatic…”
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    Effects of butylated hydroxyanisole on acetaminophen hepatotoxicity and glucuronidation in vivo by Hazelton, G A, Hjelle, J J, Klaassen, C D

    “…The present study examined the effects of butylated hydroxyanisole (BHA) on acetaminophen-induced hepatotoxicity and metabolism in vivo with emphasis on…”
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    Plasma concentrations and pharmacokinetics of phenylalanine in rats and mice administered aspartame by Hjelle, J J, Dudley, R E, Marietta, M P, Sanders, P G, Dickie, B C, Brisson, J, Kotsonis, F N

    Published in Pharmacology (1992)
    “…Aspartame (L-aspartyl-L-phenylalanine methyl ester) is an esterified, dipeptide sweetener that is rapidly and completely metabolized in the gastrointestinal…”
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    Hepatic aldehyde dehydrogenases and lipid peroxidation by Hjelle, J J, Petersen, D R

    “…Recent findings have shown that microsomal membrane lipid peroxidation generates a variety of reactive aldehydic products. The interaction of lipid…”
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    Effects of butylated hydroxyanisole on hepatic glucuronidation capacity in mice by Hazelton, G A, Hjelle, J J, Klaassen, C D

    Published in Toxicology and applied pharmacology (01-01-1985)
    “…The present study has examined biochemical mechanisms by which butylated hydroxyanisole (BHA) increases the glucuronidation of xenobiotics. Male and female…”
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    Inhibition of mitochondrial aldehyde dehydrogenase by malondialdehyde by Hjelle, J J, Grubbs, J H, Petersen, D R

    Published in Toxicology letters (01-11-1982)
    “…Rat liver mitochondria contain an aldehyde dehydrogenase (ALDH, EC 1.2.1.3) with a low Km for acetaldehyde (2 microM) which is susceptible to inhibition by a…”
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    Time course of the carbon tetrachloride-induced decrease in mitochondrial aldehyde dehydrogenase activity by Hjelle, J J, Grubbs, J H, Beer, D G, Petersen, D R

    Published in Toxicology and applied pharmacology (01-01-1983)
    “…Hepatic microsomal enzymes like cytochrome P-450 and glucose 6-phosphatase are inhibited after exposure to CCl4 in vivo. Since comparatively less is known…”
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  14. 14

    Studies on carbon tetrachloride-ethanol interactions in mice by Hjelle, J J, Gordon, A S, Petersen, D R

    Published in Toxicology letters (01-01-1982)
    “…Male C57BL/6J (C57) and DBA/2J (DBA) inbred mice were dosed with either corn oil or carbon tetrachloride (CCl4) in corn oil 24 h before a 3.25 g/kg i.p. dose…”
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    Role of sulfhydryls in the hepatotoxicity of organic and metallic compounds by Klaassen, C D, Bracken, W M, Dudley, R E, Goering, P L, Hazelton, G A, Hjelle, J J

    Published in Fundamental and applied toxicology (01-01-1985)
    “…Endogenous sulfhydryl compounds serve a critical role in maintaining the function and viability of living systems. Glutathione (GSH) is the most abundant of…”
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    The effects of disopyramide phosphate on serum glucose and glucose counterregulation in the dog by Means, J R, Hjelle, J J, Kotsonis, F N

    Published in Fundamental and applied toxicology (01-01-1985)
    “…The effect of oral administration of the antiarrhythmic disopyramide phosphate (DPP) on serum glucose and glucose counterregulation was determined in beagle…”
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    Absence of developmental effects in CF-1 mice exposed to aspartame in utero by McAnulty, P A, Collier, M J, Enticott, J, Tesh, J M, Mayhew, D A, Comer, C P, Hjelle, J J, Kotsonis, F N

    Published in Fundamental and applied toxicology (01-08-1989)
    “…Aspartame (L-aspartyl-L-phenylalanine methyl ester) is a widely used high potency dipeptide sweetener. Developmental toxicology studies have been performed in…”
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