Search Results - "Hjálmarsdóttir, Martha Á"
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Chitosan-hydroxycinnamic acid conjugates: Optimization of the synthesis and investigation of the structure activity relationship
Published in Carbohydrate polymers (01-02-2022)“…A new synthesis method was developed and optimized by a full factorial design for conjugating hydroxycinnamic acids (HCA-s) to chitosan. Cinnamic acid and…”
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The Effect of Molecular Weight on the Antibacterial Activity of N , N , N -Trimethyl Chitosan (TMC)
Published in International journal of molecular sciences (09-04-2019)“…, , -trimethyl chitosan (TMC) with 93% degree of trimethylation was synthesized. TMC and the chitosan starting material were subjected to acidic hydrolysis to…”
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The antibacterial structure-activity relationship for common chitosan derivatives
Published in International journal of biological macromolecules (15-12-2020)“…The relationship between the degree of substitution and antibacterial activity was studied for six common chitosan derivatives N, N,N-trimethyl chitosan…”
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Selective synthesis of N,N,N-trimethylated chitosan derivatives at different degree of substitution and investigation of structure-activity relationship for activity against P. aeruginosa and MRSA
Published in International journal of biological macromolecules (01-10-2020)“…Two new cationic chitosan derivatives were synthesized using a combination of Boc and TBDMS protection strategies. This included a series of six samples of the…”
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Chitotriazolan (poly(β(1-4)-2-(1H-1,2,3-triazol-1-yl)-2-deoxy-d-glucose)) derivatives: Synthesis, characterization, and evaluation of antibacterial activity
Published in Carbohydrate polymers (01-09-2021)“…Here we describe the first synthesis of a new type of polysaccharides derived from chitosan. In these structures, the 2-amino group on the pyranose ring was…”
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Synthesis of guanidinylated chitosan with the aid of multiple protecting groups and investigation of antibacterial activity
Published in Carbohydrate polymers (20-08-2015)“…•Guanidinylated chitosan derivatives were synthesized utilizing two different protecting groups.•Reactions in organic medium enabled quantitative…”
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Conjugation of CRAMP18–35 Peptide to Chitosan and Hydroxypropyl Chitosan via Copper-Catalyzed Azide–Alkyne Cycloaddition and Investigation of Antibacterial Activity
Published in International journal of molecular sciences (01-09-2024)“…We developed a synthesis strategy involving a diazo transfer reaction and subsequent click reaction to conjugate a murine cathelicidin-related antimicrobial…”
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Reduction of antimicrobial resistant pneumococci seven years after introduction of pneumococcal vaccine in Iceland
Published in PloS one (17-03-2020)“…Penicillin non-susceptible (PNSP) and multi-resistant pneumococci have been prevalent in Iceland since early nineties, mainly causing problems in treatment of…”
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Water-Soluble Quaternary and Protonable Basic Chitotriazolans: Synthesis by Click Chemistry Conversion of Chitosan Azides and Investigation of Antibacterial Activity
Published in Journal of functional biomaterials (01-03-2024)“…The azide transfer reaction and copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) can be used to convert the amino groups in chitosan to triazole…”
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Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland
Published in Journal of clinical microbiology (01-12-2018)“…Vaccination with pneumococcal conjugate vaccines (PCVs) disrupts the pneumococcal population. Our aim was to determine the impact of the 10-valent PCV on the…”
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The Effect of the 10-Valent Pneumococcal Nontypeable Haemophilus influenzae Protein D Conjugate Vaccine on H. influenzae in Healthy Carriers and Middle Ear Infections in Iceland
Published in Journal of clinical microbiology (01-07-2019)“…Vaccinations with the 10-valent pneumococcal conjugated vaccine (PHiD-CV) started in Iceland in 2011. Protein D (PD) from , which is coded for by the gene, is…”
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Comparison of Serotype Prevalence of Pneumococci Isolated from Middle Ear, Lower Respiratory Tract and Invasive Disease Prior to Vaccination in Iceland
Published in PloS one (26-01-2017)“…Information on pneumococcal serotype distribution before vaccination is a prerequisite for evaluation of vaccine effect. The aim was to investigate the…”
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Antibacterial properties of poly ( N , N -dimethylaminoethyl methacrylate) obtained at different initiator concentrations in solution polymerization
Published in Royal Society open science (01-01-2022)“…The samples of poly( , -dimethylaminoethyl methacrylate) were synthesized by radical polymerization. The amount of monomer and solvent was constant as opposed…”
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Prevalence of pilus genes in pneumococci isolated from healthy preschool children in Iceland: association with vaccine serotypes and antibiotic resistance
Published in Journal of antimicrobial chemotherapy (01-08-2015)“…The objective of this study was to investigate the prevalence of pilus islets [pilus islet 1 (PI-1) and pilus islet 2 (PI-2)] in pneumococcal isolates from…”
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Cocolonization of Pneumococcal Serotypes in Healthy Children Attending Day Care Centers: Molecular Versus Conventional Methods
Published in The Pediatric infectious disease journal (01-05-2016)“…OBJECTIVES:Pneumococci are common colonizer, especially of children, and cocolonization of different serotypes is an important factor for intraspecies genetic…”
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Water-soluble chitotriazolans derived from cationic, neutral, and anionic common chitosan derivatives: Synthesis, characterization, and antibacterial activity
Published in European polymer journal (11-09-2023)“…[Display omitted] •Mixed chitotriazolan derivatives were synthesized from common cationic, neutral, and anionic chitosan derivatives.•The free amino groups in…”
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Vaccination of Icelandic Children with the 10-Valent Pneumococcal Vaccine Leads to a Significant Herd Effect among Adults in Iceland
Published in Journal of clinical microbiology (01-04-2019)“…The introduction of pneumococcal conjugate vaccines (PCVs) into childhood vaccination programs has reduced carriage of vaccine serotypes and pneumococcal…”
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Soft Antimicrobial Agents: Synthesis and Activity of Labile Environmentally Friendly Long Chain Quaternary Ammonium Compounds
Published in Journal of medicinal chemistry (11-09-2003)“…A series of soft quaternary ammonium antimicrobial agents, which are analogues to currently used quaternary ammonium preservatives such as cetyl pyridinium…”
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Cationic quaternized aminocalix[4]arenes: cytotoxicity, haemolytic and antibacterial activities
Published in International journal of pharmaceutics (15-12-2013)“…This study reports the characterization of three cationic amphiphillic aminocalix[4]arenes as potential antimicrobial agents in vitro. In cytotoxicity tests on…”
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Impact of Chain Length on Antibacterial Activity and Hemocompatibility of Quaternary N‑Alkyl and N,N‑Dialkyl Chitosan Derivatives
Published in Biomacromolecules (11-05-2015)“…A highly efficient method for chemical modification of chitosan biopolymers by reductive amination to yield N,N-dialkyl chitosan derivatives was developed. The…”
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