Search Results - "Hizume, Kohji"

Replication fork pausing at protein barriers on chromosomes by Hizume, Kohji, Araki, Hiroyuki

“…When a cell divides prior to completion of DNA replication, serious DNA damage may occur. Thus, in addition to accuracy, the processivity of the replication…”
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Lamin B Receptor Recognizes Specific Modifications of Histone H4 in Heterochromatin Formation by Hirano, Yasuhiro, Hizume, Kohji, Kimura, Hiroshi, Takeyasu, Kunio, Haraguchi, Tokuko, Hiraoka, Yasushi

“…Inner nuclear membrane proteins provide a structural framework for chromatin, modulating transcription beneath the nuclear envelope. Lamin B receptor (LBR) is…”
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Flexible DNA Path in the MCM Double Hexamer Loaded on DNA by Hizume, Kohji, Kominami, Hiroaki, Kobayashi, Kei, Yamada, Hirofumi, Araki, Hiroyuki

“…The formation of the pre-replicative complex (pre-RC) during the G1 phase, which is also called the licensing of DNA replication, is the initial and essential…”
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In vitro observation of histone-hexamer association with and dissociation from the amino-terminal region of budding yeast Mcm2, a subunit of the replicative helicase by Hizume, Kohji

“…During DNA replication, core histones that form nucleosomes on template strands are evicted and associate with newly synthesized strands to reform nucleosomes…”
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Molecular dynamics of DNA and nucleosomes in solution studied by fast-scanning atomic force microscopy by Suzuki, Yuki, Higuchi, Yuji, Hizume, Kohji, Yokokawa, Masatoshi, Yoshimura, Shige H., Yoshikawa, Kenichi, Takeyasu, Kunio

“…Nucleosome is a fundamental structural unit of chromatin, and the exposure from or occlusion into chromatin of genomic DNA is closely related to the regulation…”
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Transcriptional Coactivator PC4, a Chromatin-Associated Protein, Induces Chromatin Condensation by Das, Chandrima, Hizume, Kohji, Batta, Kiran, Kumar, B. R. Prashanth, Gadad, Shrikanth S., Ganguly, Semanti, Lorain, Stephanie, Verreault, Alain, Sadhale, Parag P., Takeyasu, Kunio, Kundu, Tapas K.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Topoisomerase II, scaffold component, promotes chromatin compaction in vitro in a linker-histone H1-dependent manner by Hizume, Kohji, Araki, Sumiko, Yoshikawa, Kenichi, Takeyasu, Kunio

“…TopoisomeraseII (Topo II) is a major component of chromosomal scaffolds and essential for mitotic chromosome condensation, but the mechanism of this action…”
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Core Histone Charge and Linker Histone H1 Effects on the Chromatin Structure of Schizosaccharomyces pombe by PRIETO, Eloise, HIZUME, Kohji, KOBORI, Toshiro, YOSHIMURA, S. H., TAKEYASU, Kunio

“…Histones are highly conserved proteins among eukaryotes. However, yeast histones are more divergent in their sequences. In particular, the histone tail regions…”
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Protective Effect of Vitamin C against Double-Strand Breaks in Reconstituted Chromatin Visualized by Single-Molecule Observation by Yoshikawa, Yuko, Hizume, Kohji, Oda, Yoshiko, Takeyasu, Kunio, Araki, Sumiko, Yoshikawa, Kenichi

“…Direct attack to genomic DNA by reactive oxygen species causes various types of lesions, including base modifications and strand breaks. The most significant…”
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Removal of histone tails from nucleosome dissects the physical mechanisms of salt-induced aggregation, linker histone H1-induced compaction, and 30-nm fiber formation of the nucleosome array by Hizume, Kohji, Nakai, Tonau, Araki, Sumiko, Prieto, Eloise, Yoshikawa, Kenichi, Takeyasu, Kunio

“…In order to reveal the roles of histone tails in the formation of higher-order chromatin structures, we employed atomic force microscopy (AFM), and an in vitro…”
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Nano-scale analyses of the chromatin decompaction induced by histone acetylation by Hizume, Kohji, Araki, Sumiko, Hata, Kosuke, Prieto, Eloise, Kundu, Tapas K., Yoshikawa, Kenichi, Takeyasu, Kunio

“…The acetylation of histone tails is a key factor in the maintenance of chromatin dynamics and cellular homeostasis. The hallmark of active chromatin is the…”
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Single-molecule anatomy by atomic force microscopy and recognition imaging by Takahashi, Hirohide, Hizume, Kohji, Kumeta, Masahiro, Yoshimura, Shige H., Takeyasu, Kunio

“…Atomic force microscopy (AFM) has been a useful technique to visualize cellular and molecular structures at single-molecule resolution. The combination of…”
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S2-5 Molecular mechanism of initiation of chromosomal DN replication in eukaryotic cells by ARAKI Hiroyuki, MAKINO Nishiho, YAGURA Masaru, TANAKA Yoshimi, HIZUME Kohji, TANAKA Seiji

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Atomic force microscopy demonstrates a critical role of DNA superhelicity in nucleosome dynamics by Hizume, Kohji, Yoshimura, Shige H, Takeyasu, Kunio

“…Nucleosome is the most basic structural unit of eukaryotic chromosome, forming an 11 nm "beads-on-a-string" fiber. The molecular mechanism of chromatin folding…”
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DNA polymerase ε-dependent modulation of the pausing property of the CMG helicase at the barrier by Hizume, Kohji, Endo, Shizuko, Muramatsu, Sachiko, Kobayashi, Takehiko, Araki, Hiroyuki

“…The proper pausing of replication forks at barriers on chromosomes is important for genome integrity. However, the detailed mechanism underlying this process…”
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Structural organization of dynamic chromatin by Hizume, Kohji, Yoshimura, Shige H, Kumeta, Masahiro, Takeyasu, Kunio

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Chromatin Reconstitution: Development of a Salt-dialysis Method Monitored by Nano-technology by HIZUME, Kohji, YOSHIMURA, Shige H., MARUYAMA, Hugo, KIM, Joongbeak, WADA, Hitoshi, TAKEYASU, Kunio

“…The regulation of DNA replication and transcription is achieved by dynamic structural changes of chromatin in which a series of proteins will acquire…”
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Concerted interaction between origin recognition complex (ORC), nucleosomes and replication origin DNA ensures stable ORC–origin binding by Hizume, Kohji, Yagura, Masaru, Araki, Hiroyuki

“…Chromosomal replication origins, where DNA replication is initiated, are determined in eukaryotic cells by specific binding of a six‐subunit origin recognition…”
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Linker Histone H1 per se Can Induce Three-Dimensional Folding of Chromatin Fiber by Hizume, Kohji, Yoshimura, Shige H, Takeyasu, Kunio

“…Higher-order architectures of chromosomes play important roles in the regulation of genome functions. To understand the molecular mechanism of genome packing,…”
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Fundamental structural units of the Escherichia coli nucleoid revealed by atomic force microscopy by Kim, Joongbaek, Yoshimura, Shige H., Hizume, Kohji, Ohniwa, Ryosuke L., Ishihama, Akira, Takeyasu, Kunio

“…A small container of several to a few hundred µm3 (i.e. bacterial cells and eukaryotic nuclei) contains extremely long genomic DNA (i.e. mm and m long,…”
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