Association of sleep apnea with coronary slow-flow phenomenon

BACKGROUNDBoth obstructive sleep apnea (OSA) and coronary slow-flow phenomenon (CSFP) are known to share similar etiopathogenic mechanisms, such as chronic sympathetic activation, upregulation of inflammatory pathways, oxidative stress and, finally, endothelial dysfunction. OBJECTIVEWe evaluated whe...

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Published in:	Journal of cardiovascular medicine (Hagerstown, Md.) Vol. 13; no. 6; pp. 376 - 380
Main Authors:	Ozeke, Ozcan, Gungor, Mutlu, Ertan, Cagatay, Celik, Atac, Aydin, Dilek, Erturk, Ozcan, Hizel, Serap B, Ozgen, Fuat, Demir, Ahmet D, Ozer, Can
Format:	Journal Article
Language:	English
Published:	United States Italian Federation of Cardiology 01-06-2012
Subjects:	Coronary Angiography Female Humans Male Middle Aged No-Reflow Phenomenon - physiopathology Polysomnography Retrospective Studies Sleep Apnea, Obstructive - physiopathology
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Summary:	BACKGROUNDBoth obstructive sleep apnea (OSA) and coronary slow-flow phenomenon (CSFP) are known to share similar etiopathogenic mechanisms, such as chronic sympathetic activation, upregulation of inflammatory pathways, oxidative stress and, finally, endothelial dysfunction. OBJECTIVEWe evaluated whether there is an association between OSA and coronary flow rates. METHODWe retrospectively reviewed medical records of all patients who underwent diagnostic nocturnal polysomnography for suspected OSA. Those who had coronary angiography performed within the same year of polysomnography were divided into two main groupsthose with (group 1) and without (group 2) OSA; also, angiographic coronary TIMI (thrombolysis in myocardial infarction) frame counts (TFC) were compared between the groups. Patients with coronary arterial stenosis and angiograms with inadequate filling of the coronary arteries or visualization of the distal landmarks for frame counting were excluded from the study. RESULTSThere was a statistically significant difference between the groups regarding TFCs. We found a significant positive correlation between mean TFC and apnea-hypopnea index (r = 0.611, P < 0.001). CONCLUSIONThe current study demonstrated that sleep apnea impairs coronary flow rates and is associated with CSFP.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1558-2027 1558-2035
DOI:	10.2459/JCM.0b013e3283528f14