Search Results - "Hiyoshi, Takumi"

Analysis of Experimental Ligature-Induced Periodontitis Model in Mice by Tamura, Hikaru, Maekawa, Tomoki, Hiyoshi, Takumi, Terao, Yutaka

“…Periodontitis is one of the most prevalent chronic inflammatory diseases in humans. However, the disease has been hard to study, majorly because it has been…”
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Antibacterial activity of hinokitiol against both antibiotic‐resistant and ‐susceptible pathogenic bacteria that predominate in the oral cavity and upper airways by Domon, Hisanori, Hiyoshi, Takumi, Maekawa, Tomoki, Yonezawa, Daisuke, Tamura, Hikaru, Kawabata, Shigetada, Yanagihara, Katsunori, Kimura, Osamu, Kunitomo, Eiji, Terao, Yutaka

“…Hinokitiol, a component of the essential oil isolated from Cupressaceae, possesses antibacterial and antifungal activities and has been used in oral care…”
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Neutrophil elastase aggravates periodontitis by disrupting gingival epithelial barrier via cleaving cell adhesion molecules by Hiyoshi, Takumi, Domon, Hisanori, Maekawa, Tomoki, Tamura, Hikaru, Isono, Toshihito, Hirayama, Satoru, Sasagawa, Karin, Takizawa, Fumio, Tabeta, Koichi, Terao, Yutaka

“…Neutrophil elastase (NE) functions as a host defense factor; however, excessive NE activity can potentially destroy human tissues. Although NE activity is…”
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Osteoimmunology in Periodontitis: Local Proteins and Compounds to Alleviate Periodontitis by Sirisereephap, Kridtapat, Maekawa, Tomoki, Tamura, Hikaru, Hiyoshi, Takumi, Domon, Hisanori, Isono, Toshihito, Terao, Yutaka, Maeda, Takeyasu, Tabeta, Koichi

“…Periodontitis is one of the most common oral diseases resulting in gingival inflammation and tooth loss. Growing evidence indicates that it results from…”
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Ozone ultrafine bubble water exhibits bactericidal activity against pathogenic bacteria in the oral cavity and upper airway and disinfects contaminated healthcare equipment by Takizawa, Fumio, Domon, Hisanori, Hiyoshi, Takumi, Tamura, Hikaru, Shimizu, Kana, Maekawa, Tomoki, Tabeta, Koichi, Ushida, Akiomi, Terao, Yutaka

“…Ozone is strong oxidizing agent that is applied in aqueous form for sanitation. However, ozonated water is unstable and has a short half-life. Ultrafine bubble…”
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Protective effect of hinokitiol against periodontal bone loss in ligature-induced experimental periodontitis in mice by Hiyoshi, Takumi, Domon, Hisanori, Maekawa, Tomoki, Yonezawa, Daisuke, Kunitomo, Eiji, Tabeta, Koichi, Terao, Yutaka

“…•Hinokitiol inhibited the growth of oral bacteria.•Transcription of inflammatory cytokine were decreased by hinokitiol in vitro and vivo.•Hinokitiol inhibited…”
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Soybean peptide inhibits the biofilm of periodontopathic bacteria via bactericidal activity by Lwin, Hnin Yu, Aoki-Nonaka, Yukari, Matsugishi, Aoi, Takahashi, Naoki, Hiyoshi, Takumi, Tabeta, Koichi

“…This study aimed to clarify the antibacterial mechanism and antibiofilm effect of soybean-derived peptide BCBS-11 against periodontopathic bacteria. The…”
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Aggregatibacter actinomycetemcomitans induces detachment and death of human gingival epithelial cells and fibroblasts via elastase release following leukotoxin‐dependent neutrophil lysis by Hiyoshi, Takumi, Domon, Hisanori, Maekawa, Tomoki, Nagai, Kosuke, Tamura, Hikaru, Takahashi, Naoki, Yonezawa, Daisuke, Miyoshi, Tomohiro, Yoshida, Akihiro, Tabeta, Koichi, Terao, Yutaka

“…Aggregatibacter actinomycetemcomitans is considered to be associated with periodontitis. Leukotoxin (LtxA), which destroys leukocytes in humans, is one of this…”
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Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia by Domon, Hisanori, Nagai, Kosuke, Maekawa, Tomoki, Oda, Masataka, Yonezawa, Daisuke, Takeda, Wataru, Hiyoshi, Takumi, Tamura, Hikaru, Yamaguchi, Masaya, Kawabata, Shigetada, Terao, Yutaka

“…Excessive activation of neutrophils results in the release of neutrophil elastase (NE), which leads to lung injury in severe pneumonia. Previously, we…”
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Treatment of severe pneumonia by hinokitiol in a murine antimicrobial-resistant pneumococcal pneumonia model by Isono, Toshihito, Domon, Hisanori, Nagai, Kosuke, Maekawa, Tomoki, Tamura, Hikaru, Hiyoshi, Takumi, Yanagihara, Katsunori, Kunitomo, Eiji, Takenaka, Shoji, Noiri, Yuichiro, Terao, Yutaka

“…Streptococcus pneumoniae is often isolated from patients with community-acquired pneumonia. Antibiotics are the primary line of treatment for pneumococcal…”
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C-Terminal Lysine Residue of Pneumococcal Triosephosphate Isomerase Contributes to Its Binding to Host Plasminogen by Hirayama, Satoru, Hiyoshi, Takumi, Yasui, Yoshihito, Domon, Hisanori, Terao, Yutaka

“…The main causative agent of pneumonia, , is also responsible for invasive diseases. recruits human plasminogen for the invasion and colonization of host…”
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Erythromycin Restores Osteoblast Differentiation and Osteogenesis Suppressed by Porphyromonas gingivalis Lipopolysaccharide by Tamura, Hikaru, Maekawa, Tomoki, Domon, Hisanori, Sirisereephap, Kridtapat, Isono, Toshihito, Hirayama, Satoru, Hiyoshi, Takumi, Sasagawa, Karin, Takizawa, Fumio, Maeda, Takeyasu, Terao, Yutaka, Tabeta, Koichi

“…The macrolide erythromycin (ERM) inhibits excessive neutrophil accumulation and bone resorption in inflammatory tissues. We previously reported that the…”
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Sulfated vizantin causes detachment of biofilms composed mainly of the genus Streptococcus without affecting bacterial growth and viability by Hasegawa, Taisuke, Takenaka, Shoji, Oda, Masataka, Domon, Hisanori, Hiyoshi, Takumi, Sasagawa, Karin, Ohsumi, Tatsuya, Hayashi, Naoki, Okamoto, Yasuko, Yamamoto, Hirofumi, Ohshima, Hayato, Terao, Yutaka, Noiri, Yuichiro

“…Sulfated vizantin, a recently developed immunostimulant, has also been found to exert antibiofilm properties. It acts not as a bactericide, but as a…”
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Clarithromycin Inhibits Pneumolysin Production via Downregulation of ply Gene Transcription despite Autolysis Activation by Domon, Hisanori, Isono, Toshihito, Hiyoshi, Takumi, Tamura, Hikaru, Sasagawa, Karin, Maekawa, Tomoki, Hirayama, Satoru, Yanagihara, Katsunori, Terao, Yutaka

“…Streptococcus pneumoniae, the most common cause of community-acquired pneumonia, causes severe invasive infections, including meningitis and bacteremia. The…”
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Triosephosphate isomerase of Streptococcus pneumoniae is released extracellularly by autolysis and binds to host plasminogen to promote its activation by Hirayama, Satoru, Domon, Hisanori, Hiyoshi, Takumi, Isono, Toshihito, Tamura, Hikaru, Sasagawa, Karin, Takizawa, Fumio, Terao, Yutaka

“…Recruitment of plasminogen is an important infection strategy of the human pathogen Streptococcus pneumoniae to invade host tissues. In Streptococcus aureus,…”
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Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4 by Nagai, Kosuke, Domon, Hisanori, Maekawa, Tomoki, Oda, Masataka, Hiyoshi, Takumi, Tamura, Hikaru, Yonezawa, Daisuke, Arai, Yoshiaki, Yokoji, Mai, Tabeta, Koichi, Habuka, Rie, Saitoh, Akihiko, Yamaguchi, Masaya, Kawabata, Shigetada, Terao, Yutaka

“…•Pneumococcal autolysis causes release of DnaK, EF-Tu, and GAPDH associated with its DNA.•DnaK, EF-Tu, and GAPDH induced the production of proinflammatory…”
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The Pneumococcal Protein SufC Binds to Host Plasminogen and Promotes Its Conversion into Plasmin by Yasui, Yoshihito, Hirayama, Satoru, Hiyoshi, Takumi, Isono, Toshihito, Domon, Hisanori, Maekawa, Tomoki, Tabeta, Koichi, Terao, Yutaka

“…causes otitis media, sinusitis, and serious diseases such as pneumonia and bacteremia. However, the in vivo dynamics of infections and disease severity are not…”
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Erythromycin inhibits neutrophilic inflammation and mucosal disease by upregulating DEL-1 by Maekawa, Tomoki, Tamura, Hikaru, Domon, Hisanori, Hiyoshi, Takumi, Isono, Toshihito, Yonezawa, Daisuke, Hayashi, Naoki, Takahashi, Naoki, Tabeta, Koichi, Maeda, Takeyasu, Oda, Masataka, Ziogas, Athanasios, Alexaki, Vasileia Ismini, Chavakis, Triantafyllos, Terao, Yutaka, Hajishengallis, George

“…Macrolide antibiotics exert antiinflammatory effects; however, little is known regarding their immunomodulatory mechanisms. In this study, using 2 distinct…”
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Effects of Erythromycin on Osteoclasts and Bone Resorption via DEL-1 Induction in Mice by Tamura, Hikaru, Maekawa, Tomoki, Domon, Hisanori, Hiyoshi, Takumi, Hirayama, Satoru, Isono, Toshihito, Sasagawa, Karin, Yonezawa, Daisuke, Takahashi, Naoki, Oda, Masataka, Maeda, Takeyasu, Tabeta, Koichi, Terao, Yutaka

“…Macrolides are used to treat various infectious diseases, including periodontitis. Furthermore, macrolides are known to have immunomodulatory effects; however,…”
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A novel macrolide–Del-1 axis to regenerate bone in old age by Sirisereephap, Kridtapat, Tamura, Hikaru, Lim, Jong-Hyung, Surboyo, Meircurius Dwi Condro, Isono, Toshihito, Hiyoshi, Takumi, Rosenkranz, Andrea L., Sato-Yamada, Yurie, Domon, Hisanori, Ikeda, Akari, Hirose, Tomoyasu, Sunazuka, Toshiaki, Yoshiba, Nagako, Okada, Hiroyuki, Terao, Yutaka, Maeda, Takeyasu, Tabeta, Koichi, Chavakis, Triantafyllos, Hajishengallis, George, Maekawa, Tomoki

“…Aging is associated with increased susceptibility to chronic inflammatory bone loss disorders, such as periodontitis, in large part due to the impaired…”
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