Search Results - "Hiyama, Hideki"
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Analgesic effects of novel lysophosphatidic acid receptor 5 antagonist AS2717638 in rodents
Published in Neuropharmacology (01-11-2017)“…Lysophosphatidic acid (LPA) is a bioactive lipid that acts via at least six G protein-coupled receptors, LPA receptors 1–6 (LPA1-6), for various physiological…”
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Identification of potent lysophosphatidic acid receptor 5 (LPA5) antagonists as potential analgesic agents
Published in Bioorganic & medicinal chemistry (01-01-2018)“…[Display omitted] Lysophosphatidic acid (LPA) plays an important role in a variety of cellular functions. In particular, LPA5 receptor is highly expressed in…”
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Knockdown of DISC1 by In Utero Gene Transfer Disturbs Postnatal Dopaminergic Maturation in the Frontal Cortex and Leads to Adult Behavioral Deficits
Published in Neuron (Cambridge, Mass.) (25-02-2010)“…Adult brain function and behavior are influenced by neuronal network formation during development. Genetic susceptibility factors for adult psychiatric…”
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Sex-specific involvement of the Notch–JAG pathway in social recognition
Published in Translational psychiatry (10-03-2022)“…Under the hypothesis that olfactory neural epithelium gene expression profiles may be useful to look for disease-relevant neuronal signatures, we examined…”
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Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model
Published in Proceedings of the National Academy of Sciences - PNAS (22-10-2013)“…22q11 deletion syndrome (22q11DS) frequently accompanies psychiatric conditions, some of which are classified as schizophrenia and bipolar disorder in the…”
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Abnormal Development of the Olfactory Bulb and Reproductive System in Mice Lacking Prokineticin Receptor PKR2
Published in Proceedings of the National Academy of Sciences - PNAS (14-03-2006)“…Prokineticins, multifunctional secreted proteins, activate two endogenous G protein-coupled receptors PKR1 and PKR2. From in situ analysis of the mouse brain,…”
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Molecular cloning and characterization of prokineticin receptors
Published in Biochimica et biophysica acta (12-12-2002)“…Recent studies have identified two novel biofunctional proteins, termed prokineticin 1/EG-VEGF and prokineticin 2, which were mammalian homologues of mamba…”
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Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides
Published in Biochemical and biophysical research communications (20-05-2005)“…Proadrenomedullin N-terminal 20 peptide (PAMP[1–20]/PAMP-20) and its truncated analog, PAMP[9–20]/PAMP-12, are endogenous peptides that elicit hypotension…”
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evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia
Published in Proceedings of the National Academy of Sciences - PNAS (22-04-2008)“…The G protein-coupled receptor (GPCR) family is highly diversified and involved in many forms of information processing. SREB2 (GPR85) is the most conserved…”
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Molecular Cloning of Monkey Histamine H4 Receptor
Published in Journal of Pharmacological Sciences (2005)“…Histamine H4 receptor is considered as a novel therapeutic target for allergic diseases. To enhance the knowledge about species difference, which is essential…”
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Distinct localization of prokineticin 2 and prokineticin receptor 2 mRNAs in the rat suprachiasmatic nucleus
Published in The European journal of neuroscience (01-06-2006)“…The suprachiasmatic nucleus (SCN) is the master circadian clock that regulates physiological and behavioral circadian rhythms in mammals. Prokineticin 2 (PK2)…”
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Two budding yeast RAD4 homologs in fission yeast play different roles in the repair of UV-induced DNA damage
Published in DNA repair (01-10-2002)“…We have identified two fission yeast homologs of budding yeast Rad4 and human xeroderma pigmentosum complementation group C (XP-C) correcting protein,…”
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Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor
Published in Biochemical and biophysical research communications (28-01-2005)“…A lysophospholipid series, such as lysophosphatidic acid, lysophosphatidylserine, and lysophosphatidylcholine (LPC), is a bioactive lipid mediator with diverse…”
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Interaction of hHR23 with S5a
Published in The Journal of biological chemistry (24-09-1999)“…hHR23B is one of two human homologs of theSaccharomyces cerevisiae nucleotide excision repair (NER) gene product RAD23 and a component of a protein complex…”
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Molecular identification of nicotinic acid receptor
Published in Biochemical and biophysical research communications (28-03-2003)“…Nicotinic acid and its derivative, Acipimox, have been widely used in the treatment of hyperlipidemia. Pharmacological studies have demonstrated that they…”
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Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome
Published in The Journal of biological chemistry (24-09-1999)“…hHR23B is one of two human homologs of the Saccharomyces cerevisiae nucleotide excision repair (NER) gene product RAD23 and a component of a protein complex…”
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cDNA cloning and characterization of porcine histamine H4 receptor
Published in Biochimica et biophysica acta (03-05-2002)“…The cDNA encoding histamine H4 receptor was cloned from the porcine spleen cDNA library. Porcine H4 receptor, which shares 72% homology with its human…”
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