Search Results - "Hixson, E J"

Human myelomeningocele risk and ultra-rare deleterious variants in genes associated with cilium, WNT-signaling, ECM, cytoskeleton and cell migration by Au, K. S., Hebert, L., Hillman, P., Baker, C., Brown, M. R., Kim, D.-K., Soldano, K., Garrett, M., Ashley-Koch, A., Lee, S., Gleeson, J., Hixson, J. E., Morrison, A. C., Northrup, H.

“…Myelomeningocele (MMC) affects one in 1000 newborns annually worldwide and each surviving child faces tremendous lifetime medical and caregiving burdens. Both…”
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Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI by Hixson, JE, Vernier, DT

“…We have used restriction isotyping (restriction enzyme isoform genotyping) for rapid typing of common apolipoprotein E isoforms (E2, E3, E4). ApoE restriction…”
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Genetic correlation of blood pressure responses to dietary sodium and potassium intervention and cold pressor test in chinese population by Mei, H, Rice, T K, Gu, D, Hixson, J E, Jaquish, C E, Zhao, Qi, Chen, J-C, Cao, J, Li, J, Kelly, T N, Rao, D C, He, J

“…We examined the genetic association between blood pressure (BP) responses to dietary sodium and potassium intervention and to cold pressor test (CPT) in a…”
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Normal Variation in Leptin Levels Is Associated with Polymorphisms in the Proopiomelanocortin Gene, POMC by Hixson, James E, Almasy, Laura, Cole, Shelley, Birnbaum, Shifra, Mitchell, Braxton D, Mahaney, Michael C, Stern, Michael P, MacCluer, Jean W, Blangero, John, Comuzzie, Anthony G

“…ABSTRACTWe previously reported that our genome-scanning initiative had detected a highly significant linkage (log odds ratio = 4.95; P = 9 × 10) between a…”
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A Quantitative Trait Locus on Chromosome 16q Influences Variation in Plasma HDL-C Levels in Mexican Americans by Mahaney, M C, Almasy, L, Rainwater, D L, VandeBerg, J L, Cole, S A, Hixson, J E, Blangero, J, MacCluer, J W

“…OBJECTIVE—We conducted a whole-genome, multipoint linkage screen to localize a previously reported major locus accounting for 56% to 67% of the additive…”
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A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2 by Comuzzie, A.G. (Southwest Foundation for Biomedical Research, San Antonio, TX.), Hixson, J.E, Almasy, L, Mitchell, B.D, Mahaney, M.C, Dyer, T.D, Stern, M.P, MacCluer, J.W, Blangero, J

“…Obesity is a major predisposing factor for the development of several chronic diseases including non-insulin dependent diabetes mellitus (NIDDM) and coronary…”
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The contribution of individual and pairwise combinations of SNPs in the APOA1 and APOC3 genes to interindividual HDL-C variability by Brown, C M, Rea, T J, Hamon, S C, Hixson, J E, Boerwinkle, E, Clark, A G, Sing, C F

“…Apolipoproteins (apo) A-I and C-III are components of high-density lipoprotein-cholesterol (HDL-C), a quantitative trait negatively correlated with risk of…”
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A quantitative trait locus influencing BMI maps to the region of the beta-3 adrenergic receptor by MITCHELL, B. D, COLE, S. A, COMUZZIE, A. G, ALMASY, L, BLANGERO, J, MACCLUER, J. W, HIXSON, J. E

“…A quantitative trait locus influencing BMI maps to the region of the beta-3 adrenergic receptor. B D Mitchell , S A Cole , A G Comuzzie , L Almasy , J Blangero…”
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Genetic and environmental contributions to cardiovascular risk factors in Mexican Americans : The San Antonio Family Heart Study by MITCHELL, B. D, KAMMERER, C. M, VANDEBERG, J. L, STERN, M. P, MACCLUER, J. W, BLANGERO, J, MAHANEY, M. C, RAINWATER, D. L, DYKE, B, HIXSON, J. E, HENKEL, R. D, SHARP, M, COMUZZIE, A. G

“…The familial aggregation of coronary heart disease can be in large part accounted for by a clustering of cardiovascular disease risk factors. To elucidate the…”
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QTL-specific genotype-by-smoking interaction and burden of calcified coronary atherosclerosis: The NHLBI Family Heart Study by North, K.E, Carr, J.J, Borecki, I.B, Kraja, A, Province, M, Pankow, J.S, Wilk, J.B, Hixson, J.E, Heiss, G

“…Abstract Background Calcified coronary plaque (CCP) is a complex trait influenced by both genes and environment, and plausibly an interaction between the two…”
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The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans by COLE, S. A, MITCHELL, B. D, HSUEH, W.-C, PINEDA, P, BEAMER, B. A, SHULDINER, A. R, COMUZZIE, A. G, BLANGERO, J, HIXSON, J. E

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Baboons as an Animal Model for Genetic Studies of Common Human Disease by Rogers, Jeffrey, Hixson, James E.

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Human Pedigree-Based Quantitative-Trait–Locus Mapping: Localization of Two Genes Influencing HDL-Cholesterol Metabolism by Almasy, Laura, Hixson, James E., Rainwater, David L., Cole, Shelley, Williams, Jeff T., Mahaney, Michael C., VandeBerg, John L., Stern, Michael P., MacCluer, Jean W., Blangero, John

“…Common disorders with genetic susceptibilities involve the action of multiple genes interacting with each other and with environmental factors, making it…”
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Common variants in the Na+-coupled bicarbonate transporter genes and salt sensitivity of blood pressure: the GenSalt study by Guo, L, Liu, F, Chen, S, Yang, X, Huang, J, He, J, Jaquish, C E, Zhao, Q, Gu, C C, Hixson, J E, Gu, D

“…The current study comprehensively examined the association between common variants in the Na + -coupled bicarbonate transporter (NCBT) genes and blood pressure…”
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Molecular basis for "null" lipoprotein(a) phenotypes and the influence of apolipoprotein(a) size on plasma lipoprotein(a) level in the baboon by White, A.L, Hixson, J.E, Rainwater, D.L, Lanford, R.E

“…High plasma levels of lipoprotein(a) (Lp(a)) and its unique apolipoprotein, apo(a), are an independent risk factor for cardiovascular disease. Plasma Lp(a)…”
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A paired sibling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans by Mitchell, B D, Blangero, J, Comuzzie, A G, Almasy, L A, Shuldiner, A R, Silver, K, Stern, M P, MacCluer, J W, Hixson, J E

“…The beta3 adrenergic receptor, located on chromosome 8, is a regulator of energy expenditure and lipolysis. A missense mutation in this gene, characterized by…”
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A Genome Search Identifies Major Quantitative Trait Loci on Human Chromosomes 3 and 4 That Influence Cholesterol Concentrations in Small LDL Particles by Rainwater, David L, Almasy, Laura, Blangero, John, Cole, Shelley A, VandeBerg, John L, MacCluer, Jean W, Hixson, James E

“…Small, dense LDL particles are associated with increased risk of cardiovascular disease. To identify the genes that influence LDL size variation, we performed…”
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The PPAR alpha gene is associated with triglyceride, low-density cholesterol and inflammation marker response to fenofibrate intervention: the GOLDN study by Frazier-Wood, A C, Ordovas, J M, Straka, R J, Hixson, J E, Borecki, I B, Tiwari, H K, Arnett, D K

“…As a peroxisome proliferator-activated receptor alpha (PPARα) agonist, fenofibrate favorably modulates dyslipidemia and inflammation markers, which are…”
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Common Genetic Variants in the Endothelial System Predict Blood Pressure Response to Sodium Intake: The GenSalt Study by Defagó, Maria Daniela, Gu, Dongfeng, Hixson, James E., Shimmin, Lawrence C., Rice, Treva K., Gu, Charles C., Jaquish, Cashell E., Liu, De-Pei, He, Jiang, Kelly, Tanika N.

“…BACKGROUND We examined the association between 14 endothelial system genes and salt-sensitivity of blood pressure (BP). METHODS After a 3-day baseline…”
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Linkage exclusion analysis of the chromosome 11 region containing UCP2 and UCP3 with obesity-related phenotypes in Mexican Americans by Gomuzzie, A.G, Almasy, L, Cole, S.A, Boss, O, Giacobino, J.P, Muzzin, P, Stern, M.P, MacCluer, J.W, Blangero, J, Hixson, J.E

“…OBJECTIVE: To investigate whether the region of chromosome 11 (11q13) containing the genes UCP2 and UCP3 could be excluded for linkage with a variety of…”
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