Search Results - "Hiwase, D"

TGF-α and IL-6 plasma levels selectively identify CML patients who fail to achieve an early molecular response or progress in the first year of therapy by Nievergall, E, Reynolds, J, Kok, C H, Watkins, D B, Biondo, M, Busfield, S J, Vairo, G, Fuller, K, Erber, W N, Sadras, T, Grose, R, Yeung, D T, Lopez, A F, Hiwase, D K, Hughes, T P, White, D L

“…Early molecular response (EMR, BCR-ABL1 (IS)⩽10% at 3 months) is a strong predictor of outcome in imatinib-treated chronic phase chronic myeloid leukemia…”
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Sustained inhibition of STAT5, but not JAK2, is essential for TKI-induced cell death in chronic myeloid leukemia by Schafranek, L, Nievergall, E, Powell, J A, Hiwase, D K, Leclercq, T, Hughes, T P, White, D L

“…Kinase inhibitors block proliferative signals in BCR-ABL1+ leukemic cells, but their capacity to induce apoptosis is poorly understood. Initial studies…”
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A tale of two siblings: two cases of AML arising from a single pre-leukemic DNMT3A mutant clone by Hahn, C N, Ross, D M, Feng, J, Beligaswatte, A, Hiwase, D K, Parker, W T, Ho, M, Zawitkowski, M, Ambler, K L, Cheetham, G D, Lee, Y K, Babic, M, Butcher, C M, Engler, G A, Brown, A L, D'Andrea, R J, Lewis, I D, Schreiber, A W, To, L B, Scott, H S

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Iron Chelation Therapy is Associated with Improved Survival in Lower Risk MDS by Singhal, D, Chhetri, R, Wee, L.A, Kutyna, M, Nath, S, Hiwase, D

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Cotransplantation of Placental Mesenchymal Stromal Cells Enhances Single and Double Cord Blood Engraftment in Nonobese Diabetic/Severe Combined Immune Deficient Mice by Hiwase, Smita D, Dyson, Pamela G, To, L. Bik, Lewis, Ian D.

“…Limited cell numbers in a unit restricts cord blood transplantation (CBT) in adults. We evaluated whether cotransplantation of placental mesenchymal stromal…”
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Blocking cytokine signaling along with intense Bcr-Abl kinase inhibition induces apoptosis in primary CML progenitors by Hiwase, D K, White, D L, Powell, J A, Saunders, V A, Zrim, S A, Frede, A K, Guthridge, M A, Lopez, A F, D'Andrea, R J, To, L B, Melo, J V, Kumar, S, Hughes, T P

“…In chronic myeloid leukemia (CML) cell lines, brief exposure to pharmacologically relevant dasatinib concentrations results in apoptosis. In this study, we…”
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Nilotinib-mediated inhibition of ABCB1 increases intracellular concentration of dasatinib in CML cells: implications for combination TKI therapy by Hiwase, D K, White, D, Zrim, S, Saunders, V, Melo, J V, Hughes, T P

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Proton pump inhibitors significantly increase the intracellular concentration of nilotinib, but not imatinib in target CML cells by White, D L, Eadie, L N, Saunders, V A, Hiwase, D K, Hughes, T P

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P776: A PHASE 2, OPEN‐LABEL, ASCENDING DOSE STUDY OF KER‐050 FOR THE TREATMENT OF ANEMIA IN PATIENTS WITH VERY LOW, LOW, OR INTERMEDIATE RISK MYELODYSPLASTIC SYNDROMES by Tan, S., Arbelaez, A., Chee, L., Fong, C. Y., Hiwase, D., Kannourakis, G., Kwan, J., Liang, J., Puliyayil, A., Rose, H., Ross, D., Teh, T.‐C., Westerman, D., Wight, J., Feng, W., Lachey, J., McGinty, A., Natarajan, H., Rovaldi, C., Cooper, S.

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Therapy Related Myeloid Neoplasms (T-MN) Show High Mutation Frequency and a Spectrum Different from Primary MDS by Singhal, D, Wee, L.A, Babic, M, Parker, W, Moore, S, Feng, J, Schreiber, A, Geoghegan, J, Kutyna, M, Chhetri, R, Nath, S, Singhal, N, Gowda, R, Ross, D, To, L.B, D’Andrea, R, Lewis, I, Hahn, C, Scott, H, Hiwase, D

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Relapsed multiple myeloma: who benefits from salvage autografts? by Chow, A. W. S., Lee, C. H. S., Hiwase, D. K., To, L. B., Horvath, N.

“…Background Multiple myeloma is incurable despite the advance of autologous stem cell transplant (ASCT) and novel agents (thalidomide, bortezomib,…”
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155 SNP-MICROARRAY OF PERIPHERAL BLOOD-GRANULOCYTES DNA CAN DETECT CLONAL EVOLUTION IN MYELODYSPLASTIC SYNDROMES (MDS) by Hiwase, D, Moore, S, Kutyna, M, Fraser, R, Singhal, D, Chhetri, R, Lewis, I, Bardy, P, To, L. Bik, Scott, H

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P-122 Transfusion dependency is associated with inferior outcome in very low- and low-risk IPSS-R patients by Hiwase, D, Kutyna, M, Carr, T, Harrison, P, Melo, J.V, Bardy, P, To, L.B

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154 TARGETED MUTATION SEQUENCING AND SNP-MICRORRAY CAN IDENTIFY POOR PROGNOSTIC GROUP IN IPSS-LOWER RISK GROUP by Hiwase, D, Moore, S, Hahn, C, Kutyna, M, Van Der Hoek, M, Fraser, R, Chhetri, R, Singhal, D, Lewis, I, Bardy, P, To, L. Bik, Scott, H

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153 MULTIPLE MUTATIONS IN THE SAME GENE SUGGEST CLONAL DIVERSITY AND IS ASSOCIATED WITH POOR PROGNOSIS IN MDS by Hiwase, D, Hahn, C, Babic, M, Moore, S, Singhal, D, Kutyna, M, Chhetri, R, Lopez, A, Heatley, S, Feng, J, Bardy, P, Ross, D, Lewis, I.A.N, To, B.I.K, Schreiber, A, Scott, H

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13 THE ADDITION OF LENALIDOMIDE TO AZACITIDINE ACHIEVES HIGHER RESPONSES BUT NO IMPROVEMENT IN TWELVE MONTH CLINICAL BENEFIT OR PFS; MAIN ANALYSIS AUSTRALIAN ALLG MDS4 TRIAL by Kenealy, M, Benson, W, Stevenson, W, Eek, R, Zantomio, D, Cunningham, I, Hiwase, D, Cowan, L, Vlachos, S, Zannino, D, Seymour, J.F

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Short-term intense Bcr-Abl kinase inhibition with nilotinib is adequate to trigger cell death in BCR-ABL cells by Hiwase, D K, White, D L, Saunders, V A, Kumar, S, Melo, J V, Hughes, T P

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Intermediate-dose CY and G-CSF more efficiently mobilize adequate numbers of PBSC for tandem autologous PBSC transplantation compared with low-dose CY in patients with multiple myeloma by Hiwase, D.K, Bollard, G, Hiwase, S, Bailey, M, Muirhead, J, Schwarer, A.P

“…Background Autologous PBSC transplantation is the standard care for patients with multiple myeloma. The most common regimen used to mobilize PBSC consists of…”
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P-272 The combination of azacitidine and lenalidomide is deliverable without unexpected toxicity; interim safety results of the ALLG MDS4 randomised trial by Kenealy, M, Seymour, J.F, Benson, W, Stevenson, W, Eek, R, Zantomio, D, Cunningham, I, Hiwase, D, Cowan, L, Zannino, D

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Can rotational thromboelastometry rapidly identify theragnostic targets in isolated traumatic brain injury? by Hiwase, Abhiram D, Ovenden, Christopher D, Kaukas, Lola M, Finnis, Mark, Zhang, Zeyu, O'Connor, Stephanie, Foo, Ngee, Reddi, Benjamin, Wells, Adam J, Ellis, Daniel Y

“…Coagulation assessment in traumatic brain injury (TBI) typically relies upon laboratory-based standard coagulation tests (SCTs), including the activated…”
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