Search Results - "Hivroz, C."

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity by Rieux-Laucat, F., Le Deist, F., Hivroz, C., Roberts, I. A. G., Debatin, K. M., Fischer, A., de Villartay, J. P.

“…Fas (also known as Apo1 and CD95) is a cell surface receptor involved in apoptotic cell death. Fas expression and function were analyzed in three children…”
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The calcium current activated by T cell receptor and store depletion in human lymphocytes is absent in a primary immunodeficiency by Partiseti, M, Le Deist, F, Hivroz, C, Fischer, A, Korn, H, Choquet, D

“…Stimulation of antigen receptors of lymphocytes triggers a transitory release of Ca2+ from internal stores and the opening of a transmembrane Ca2+ conductive…”
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NATURALLY OCCURRING PRIMARY DEFICIENCIES OF THE IMMUNE SYSTEM by Fischer, A, Cavazzana-Calvo, M, Basile, G. De Saint, DeVillartay, J. P, Di Santo, J. P, Hivroz, C, Rieux-Laucat, F, Le Deist, F

“…Naturally occurring genetic disorders of the immune system provide many models for the study of its development and function. In a way, their analysis…”
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Abnormal CD40-mediated activation pathway in B lymphocytes from patients with hyper-IgM syndrome and normal CD40 ligand expression by Durandy, A, Hivroz, C, Mazerolles, F, Schiff, C, Bernard, F, Jouanguy, E, Revy, P, DiSanto, JP, Gauchat, JF, Bonnefoy, JY, Casanova, JL, Fischer, A

“…The CD40-mediated activation pathway of B cells from 10 patients with hyper-IgM syndrome and normal expression of CD40 ligand was studied. In all 10 cases, B…”
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Immunodeficiency diseases. Multiple roles for ZAP-70 by Hivroz, C, Fischer, A

“…Human patients with an immunodeficiency disease caused by mutations of the protein tyrosine kinase ZAP-70 show that this enzyme plays multiple important roles…”
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γc Gene Transfer Into SCID X1 Patients’ B-Cell Lines Restores Normal High-Affinity Interleukin-2 Receptor Expression and Function by Hacein-Bey, S., Cavazzana-Calvo, M., Deist, F.Le, Dautry-Varsat, A., Hivroz, C., Rivière, I., Danos, O., Heard, J.M., Sugamura, K., Fischer, A., Basile, G.De Saint

“…SCID X1 is characterized by faulty T-cell and natural killer cell differentiation caused by mutation of the γc chain gene encoding a number of multiple…”
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Crosstalk between T lymphocytes and dendritic cells by Hivroz, Claire, Chemin, Karine, Tourret, Marie, Bohineust, Armelle

“…Dendritic cells (DCs) are professional antigen-presenting cells (APCs) with the unique property of inducing priming and differentiation of naïve CD4+ and CD8+…”
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Phosphatidylinositol 3-kinase participates in p56(lck)/CD4-dependent down-regulation of LFA-1-mediated T cell adhesion by Mazerolles, F, Barbat, C, Hivroz, C, Fischer, A

“…The mechanism inducing cell detachment in Ag-independent adhesion between lymphocytes is poorly understood. Different putative CD4 ligands, anti-CD4 Ab, a…”
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Critical role for TRIM28 and HP1β/γ in the epigenetic control of T cell metabolic reprograming and effector differentiation by Gehrmann, Ulf, Burbage, Marianne, Zueva, Elina, Goudot, Christel, Esnault, Cyril, Ye, Mengliang, Carpier, Jean-Marie, Burgdorf, Nina, Hoyler, Thomas, Suarez, Guadalupe, Joannas, Leonel, Heurtebise-Chrétien, Sandrine, Durand, Sylvère, Panes, Rébecca, Bellemare-Pelletier, Angélique, Sáez, Pablo J., Aprahamian, Fanny, Lefevre, Deborah, Adoue, Veronique, El Aabidine, Amal Zine, Ahmad, Maqbool Muhammad, Hivroz, Claire, Joffre, Olivier, Cammas, Florence, Kroemer, Guido, Gagnon, Etienne, Andrau, Jean-Christophe, Amigorena, Sebastian

“…Naive CD4⁺ T lymphocytes differentiate into different effector types, including helper and regulatory cells (Th and Treg, respectively). Heritable gene…”
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TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex by Blanchard, Nicolas, Lankar, Danielle, Faure, Florence, Regnault, Armelle, Dumont, Céline, Raposo, Graça, Hivroz, Claire

“…We show in this study that human T cells purified from peripheral blood, T cell clones, and Jurkat T cells release microvesicles in the culture medium. These…”
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Early biochemical events after MHC class II-mediated signaling on human B lymphocytes by Mooney, NA, Grillot-Courvalin, C, Hivroz, C, Ju, LY, Charron, D

“…These studies examined the role of the MHC class II Ag in signal transduction using human B lymphocytes. Early events in signal transduction were considered…”
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In the Immune Synapse, ZAP-70 Controls T Cell Polarization and Recruitment of Signaling Proteins but Not Formation of the Synaptic Pattern by Blanchard, Nicolas, Di Bartolo, Vincenzo, Hivroz, Claire

“…Recognition by T cells of their ligands at the surface of antigen-presenting cells (APCs) leads to T cell activation, polarization of the T cell toward the…”
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Heterogeneity of responsiveness of chronic lymphocytic leukemic B cells to B cell growth factor or interleukin 2 by Hivroz, C, Grillot-Courvalin, C, Brouet, J C, Seligmann, M

“…We compared the proliferative responses of purified human leukemic B cells from 12 cases of chronic lymphocytic leukemia to highly purified B cell growth…”
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Dendritic Cell Maturation Controls Adhesion, Synapse Formation, and the Duration of the Interactions with Naive T Lymphocytes by Benvenuti, Federica, Lagaudriere-Gesbert, Cecile, Grandjean, Isabelle, Jancic, Carolina, Hivroz, Claire, Trautmann, Alain, Lantz, Olivier, Amigorena, Sebastian

“…The initiation of adaptive immune responses requires the direct interaction of dendritic cells (DCs) with naive T lymphocytes. It is well established that the…”
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Dynamic recruitment of the adaptor protein LAT: LAT exists in two distinct intracellular pools and controls its own recruitment by Bonello, Grégory, Blanchard, Nicolas, Montoya, Maria C, Aguado, Enrique, Langlet, Claire, He, Hai-Tao, Nunez-Cruz, Selena, Malissen, Marie, Sanchez-Madrid, Francisco, Olive, Daniel, Hivroz, Claire, Collette, Yves

“…The integral membrane adaptor protein linker for activation of T cells (LAT) couples the T-cell receptor (TCR) with downstream signalling and is essential for…”
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Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Guérin infection and a sibling with clinical tuberculosis by Jouanguy, E, Lamhamedi-Cherradi, S, Altare, F, Fondanèche, M C, Tuerlinckx, D, Blanche, S, Emile, J F, Gaillard, J L, Schreiber, R, Levin, M, Fischer, A, Hivroz, C, Casanova, J L

“…Complete interferon-gamma receptor 1 (IFNgammaR1) deficiency has been identified previously as a cause of fatal bacillus Calmette-Guérin (BCG) infection with…”
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Everything you ever wanted to know about ZAP-70 by Hivroz, Claire

“…The ZAP-70 tyrosine kinase has been described more than ten years ago. Its key role in thymocytes development and mature T lymphocytes activation has been…”
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Functional T cell immunodeficiency characterized by defective TCR/CD3 induced tyrosylphosphorylation by Hivroz, C, Le Deist, F, Buc, H A, Griscelli, C, Fischer, A

“…Defective T cell activation has been recognized in a number of patients with primary immunodeficiencies (ID). A distal defect resulting in abnormal production…”
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Strong and durable TCR clustering at the T/dendritic cell immune synapse is not required for NFAT activation and IFN-gamma production in human CD4+ T cells by Blanchard, Nicolas, Decraene, Maud, Yang, Kun, Miro-Mur, Francesc, Amigorena, Sebastian, Hivroz, Claire

“…The exact function of TCR clustering and organized macromolecular patterns at the immune synapse between APCs and T lymphocytes is unclear. Using human…”
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Phosphoinositide 3-Kinase Activation by Igβ Controls de Novo Formation of an Antigen-processing Compartment by Granboulan, Marie, Lankar, Danielle, Raposo, Graça, Bonnerot, Christian, Hivroz, Claire

“…Antigens that bind B cell antigen receptor (BCR) are preferentially and rapidly processed for antigen presentation. The BCR is a multimeric complex containing…”
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