Search Results - "Hittelman, Walter"

Cell Cycle-Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells by Kothari, Anisha, Hittelman, Walter N, Chambers, Timothy C

“…Microtubule-targeting agents (MTA), such as the taxanes and vinca alkaloids, are used to treat a variety of cancers due to their ability to perturb microtubule…”
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Pannexin-1 Up-regulation in the Dorsal Root Ganglion Contributes to Neuropathic Pain Development by Zhang, Yuhao, Laumet, Geoffroy, Chen, Shao-Rui, Hittelman, Walter N., Pan, Hui-Lin

“…Pannexin-1 (Panx1) is a large-pore membrane channel involved in the release of ATP and other signaling mediators. Little is known about the expression and…”
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COTI-2, A Novel Thiosemicarbazone Derivative, Exhibits Antitumor Activity in HNSCC through p53-dependent and -independent Mechanisms by Lindemann, Antje, Patel, Ameeta A, Silver, Natalie L, Tang, Lin, Liu, Zhiyi, Wang, Li, Tanaka, Noriaki, Rao, Xiayu, Takahashi, Hideaki, Maduka, Nakachi K, Zhao, Mei, Chen, Tseng-Cheng, Liu, WeiWei, Gao, Meng, Wang, Jing, Frank, Steven J, Hittelman, Walter N, Mills, Gordon B, Myers, Jeffrey N, Osman, Abdullah A

“…53 mutations are highly prevalent in head and neck squamous cell carcinoma (HNSCC) and associated with increased resistance to conventional treatment primarily…”
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Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain by Li, Lingyong, Chen, Shao-Rui, Chen, Hong, Wen, Lei, Hittelman, Walter N., Xie, Jing-Dun, Pan, Hui-Lin

“…Chronic neuropathic pain is a debilitating condition that remains difficult to treat. Diminished synaptic inhibition by GABA and glycine and increased NMDA…”
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Regulating nociceptive transmission by VGluT2‐expressing spinal dorsal horn neurons by Wang, Li, Chen, Shao‐Rui, Ma, Huijie, Chen, Hong, Hittelman, Walter N., Pan, Hui‐Lin

“…Vesicular glutamate transporter‐2 (VGluT2) mediates the uptake of glutamate into synaptic vesicles in neurons. Spinal cord dorsal horn interneurons are highly…”
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Ataxia-telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma by Sarkar, Aloke, Stellrecht, Christine M, Vangapandu, Hima V, Ayres, Mary, Kaipparettu, Benny A, Park, Jun Hyoung, Balakrishnan, Kumudha, Burks, Jared K, Pandita, Tej K, Hittelman, Walter N, Neelapu, Sattva S, Gandhi, Varsha

“…Ataxia telangiectasia mutated (ATM), a critical DNA damage sensor with protein kinase activity,is frequently altered in human cancers including mantle cell…”
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MOF Phosphorylation by ATM Regulates 53BP1-Mediated Double-Strand Break Repair Pathway Choice by Gupta, Arun, Hunt, Clayton R., Hegde, Muralidhar L., Chakraborty, Sharmistha, Udayakumar, Durga, Horikoshi, Nobuo, Singh, Mayank, Ramnarain, Deepti B., Hittelman, Walter N., Namjoshi, Sarita, Asaithamby, Aroumougame, Hazra, Tapas K., Ludwig, Thomas, Pandita, Raj K., Tyler, Jessica K., Pandita, Tej K.

“…Cell-cycle phase is a critical determinant of the choice between DNA damage repair by nonhomologous end-joining (NHEJ) or homologous recombination (HR). Here,…”
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CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death by Liu, Xiaojun, Jiang, Yingjun, Takata, Kei-Ichi, Nowak, Billie, Liu, Chaomei, Wood, Richard D, Hittelman, Walter N, Plunkett, William

“…Incorporation of the clinically active deoxycytidine analogue 2'- -cyano-2'-deoxy-1-β-D-arabino-pentofuranosyl-cytosine (CNDAC) into DNA generates…”
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Mesenchymal stem cells and macrophages interact through IL-6 to promote inflammatory breast cancer in pre-clinical models by Wolfe, Adam R, Trenton, Nicholaus J, Debeb, Bisrat G, Larson, Richard, Ruffell, Brian, Chu, Khoi, Hittelman, Walter, Diehl, Michael, Reuben, Jim M, Ueno, Naoto T, Woodward, Wendy A

“…Inflammatory breast cancer (IBC) is a unique and deadly disease with unknown drivers. We hypothesized the inflammatory environment contributes to the IBC…”
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CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition by Gadhikar, Mayur A, Zhang, Jiexin, Shen, Li, Rao, Xiayu, Wang, Jing, Zhao, Mei, Kalu, Nene N, Johnson, Faye M, Byers, Lauren A, Heymach, John, Hittelman, Walter N, Udayakumar, Durga, Pandita, Raj K, Pandita, Tej K, Pickering, Curtis R, Redwood, Abena B, Piwnica-Worms, Helen, Schlacher, Katharina, Frederick, Mitchell J, Myers, Jeffrey N

“…Checkpoint kinase inhibitors (CHKi) exhibit striking single-agent activity in certain tumors, but the mechanisms accounting for hypersensitivity are poorly…”
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Prevention of Paclitaxel-Induced Neuropathy Through Activation of the Central Cannabinoid Type 2 Receptor System by Naguib, Mohamed, Xu, Jijun J., Diaz, Philippe, Brown, David L., Cogdell, David, Bie, Bihua, Hu, Jianhua, Craig, Suzanne, Hittelman, Walter N.

“…Peripheral neuropathy is a major dose-limiting toxicity of chemotherapy, especially after multiple courses of paclitaxel. The development of paclitaxel-induced…”
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Cancer Stem Cells and Tumor Response to Therapy: Current Problems and Future Prospects by Milas, Luka, MD, PhD, Hittelman, Walter N., PhD

“…The presence of a subpopulation of cells within tumors, so-called cancer stemlike cells, that is uniquely capable of reestablishing the tumor during and after…”
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Development of a human immuno-oncology therapeutic agent targeting HER2: targeted delivery of granzyme B by Cheung, Lawrence H, Zhao, Yunli, Alvarez-Cienfuegos, Ana, Mohamedali, Khalid A, Cao, Yu J, Hittelman, Walter N, Rosenblum, Michael G

“…Immunotherapeutic approaches designed to augment T and B cell mediated killing of tumor cells has met with clinical success in recent years suggesting…”
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Sensing of blood pressure increase by transient receptor potential vanilloid 1 receptors on baroreceptors by Sun, Hao, Li, De-Pei, Chen, Shao-Rui, Hittelman, Walter N, Pan, Hui-Lin

“…The arterial baroreceptor is critically involved in the autonomic regulation of homoeostasis. The transient receptor potential vanilloid 1 (TRPV1) receptor is…”
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Antagonism of Tumoral Prolactin Receptor Promotes Autophagy-Related Cell Death by Wen, Yunfei, Zand, Behrouz, Ozpolat, Bulent, Szczepanski, Miroslaw J., Lu, Chunhua, Yuca, Erkan, Carroll, Amy R., Alpay, Neslihan, Bartholomeusz, Chandra, Tekedereli, Ibrahim, Kang, Yu, Rupaimoole, Rajesha, Pecot, Chad V., Dalton, Heather J., Hernandez, Anadulce, Lokshin, Anna, Lutgendorf, Susan K., Liu, Jinsong, Hittelman, Walter N., Chen, Wen Y., Lopez-Berestein, Gabriel, Szajnik, Marta, Ueno, Naoto T., Coleman, Robert L., Sood, Anil K.

“…Therapeutic upregulation of macroautophagy in cancer cells provides an alternative mechanism for cell death. Prolactin (PRL) and its receptor (PRLR) are…”
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14-3-3ζ Overexpression Defines High Risk for Breast Cancer Recurrence and Promotes Cancer Cell Survival by NEAL, Christopher L, JUN YAO, HITTELMAN, Walter, HUNG, Mien-Chie, DIHUA YU, WENTAO YANG, XIAOYAN ZHOU, NGUYEN, Nina T, JING LU, DANES, Christopher G, HUA GUO, LAN, Keng-Hsueh, ENSOR, Joe

“…Abstract The ubiquitously expressed 14-3-3 proteins are involved in numerous important cellular functions. The loss of 14-3-3σ is a common event in breast…”
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RING Finger and WD Repeat Domain 3 (RFWD3) Associates with Replication Protein A (RPA) and Facilitates RPA-mediated DNA Damage Response by Liu, Shangfeng, Chu, Jessica, Yucer, Nur, Leng, Mei, Wang, Shih-Ya, Chen, Benjamin P.C., Hittelman, Walter N., Wang, Yi

“…DNA damage response is crucial for maintaining genomic integrity and preventing cancer by coordinating the activation of checkpoints and the repair of damaged…”
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Preparation of Primary Acute Lymphoblastic Leukemia Cells in Different Cell Cycle Phases by Centrifugal Elutriation by Delgado, Magdalena, Kothari, Anisha, Hittelman, Walter N, Chambers, Timothy C

“…The ability to synchronize cells has been central to advancing our understanding of cell cycle regulation. Common techniques employed include serum…”
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Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk TP53 Mutation by Tanaka, Noriaki, Patel, Ameeta A, Tang, Lin, Silver, Natalie L, Lindemann, Antje, Takahashi, Hideaki, Jaksik, Roman, Rao, Xiayu, Kalu, Nene N, Chen, Tseng-Cheng, Wang, Jiping, Frederick, Mitchell J, Johnson, Faye, Gleber-Netto, Frederico O, Fu, Siqing, Kimmel, Marek, Wang, Jing, Hittelman, Walter N, Pickering, Curtis R, Myers, Jeffrey N, Osman, Abdullah A

“…The cure rate for patients with advanced head and neck squamous cell carcinoma (HNSCC) remains poor due to resistance to standard therapy primarily consisting…”
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Multiplexed In Situ Immunofluorescence Using Dynamic DNA Complexes by Schweller, Ryan M., Zimak, Jan, Duose, Dzifa Y., Qutub, Amina A., Hittelman, Walter N., Diehl, Michael R.

“…DNA‐based erasers: The designed strand‐displacement reactions between dynamic DNA probes (carrying fluorescent dyes (★) and quencher domains (•)) and…”
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