Search Results - "Hitoshi Kurose"

Cardiac Fibrosis and Fibroblasts by Kurose, Hitoshi

“…Cardiac fibrosis is the excess deposition of extracellular matrix (ECM), such as collagen. Myofibroblasts are major players in the production of collagen, and…”
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Pharmacology of Antagonism of GPCR by Kurose, Hitoshi, Kim, Sang Geon

“…Agonists are defined as the ligands that activate intracellular signaling and evoke cellular responses. Synthetic and endogenous agonists should bind specific…”
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Therapeutic Targets for the Treatment of Cardiac Fibrosis and Cancer: Focusing on TGF-β Signaling by Parichatikanond, Warisara, Luangmonkong, Theerut, Mangmool, Supachoke, Kurose, Hitoshi

“…Transforming growth factor-β (TGF-β) is a common mediator of cancer progression and fibrosis. Fibrosis can be a significant pathology in multiple organs,…”
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Myofibroblasts and inflammatory cells as players of cardiac fibrosis by Kurose, Hitoshi, Mangmool, Supachoke

“…On myocardial infarction, many cells are injured or died owing to arterial occlusion. Intracellular molecules released from injured or dead cells initiate…”
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New Therapeutics for Heart Failure: Focusing on cGMP Signaling by Mangmool, Supachoke, Duangrat, Ratchanee, Parichatikanond, Warisara, Kurose, Hitoshi

“…Current drugs for treating heart failure (HF), for example, angiotensin II receptor blockers and β-blockers, possess specific target molecules involved in the…”
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Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis by Yoshida, Yuya, Matsunaga, Naoya, Nakao, Takaharu, Hamamura, Kengo, Kondo, Hideaki, Ide, Tomomi, Tsutsui, Hiroyuki, Tsuruta, Akito, Kurogi, Masayuki, Nakaya, Michio, Kurose, Hitoshi, Koyanagi, Satoru, Ohdo, Shigehiro

“…Dysfunction of the circadian clock has been implicated in the pathogenesis of cardiovascular disease. The CLOCK protein is a core molecular component of the…”
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Gi/o Protein-Dependent and -Independent Actions of Pertussis Toxin (PTX) by Mangmool, Supachoke, Kurose, Hitoshi

“…Pertussis toxin (PTX) is a typical A-B toxin. The A-protomer (S1 subunit) exhibits ADP-ribosyltransferase activity. The B-oligomer consists of four subunits…”
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Gα12 and Gα13 as key regulatory mediator in signal transduction by Kurose, Hitoshi

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Gα12/13 signaling in metabolic diseases by Yang, Yoon Mee, Kuen, Da-Sol, Chung, Yeonseok, Kurose, Hitoshi, Kim, Sang Geon

“…As the key governors of diverse physiological processes, G protein-coupled receptors (GPCRs) have drawn attention as primary targets for several diseases,…”
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Regulation of β-Adrenergic Receptors in the Heart: A Review on Emerging Therapeutic Strategies for Heart Failure by Parichatikanond, Warisara, Duangrat, Ratchanee, Kurose, Hitoshi, Mangmool, Supachoke

“…The prolonged overstimulation of β-adrenergic receptors (β-ARs), a member of the G protein-coupled receptor (GPCR) family, causes abnormalities in the density…”
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The MAPK Erk5 is necessary for proper skeletogenesis involving a Smurf-Smad-Sox9 molecular axis by Iezaki, Takashi, Fukasawa, Kazuya, Horie, Tetsuhiro, Park, Gyujin, Robinson, Samuel, Nakaya, Michio, Fujita, Hiroyuki, Onishi, Yuki, Ozaki, Kakeru, Kanayama, Takashi, Hiraiwa, Manami, Kitaguchi, Yuka, Kaneda, Katsuyuki, Yoneda, Yukio, Takarada, Takeshi, Guo, X Edward, Kurose, Hitoshi, Hinoi, Eiichi

“…Erk5 belongs to the mitogen-activated protein kinase (MAPK) family. Following its phosphorylation by Mek5, Erk5 modulates several signaling pathways in a…”
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Therapeutic Targets for Treatment of Heart Failure: Focus on GRKs and β-Arrestins Affecting βAR Signaling by Mangmool, Supachoke, Parichatikanond, Warisara, Kurose, Hitoshi

“…Heart failure (HF) is a heart disease that is classified into two main types: HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction…”
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Multiple functions of G protein-coupled receptor kinases by Watari, Kenji, Nakaya, Michio, Kurose, Hitoshi

“…Desensitization is a physiological feedback mechanism that blocks detrimental effects of persistent stimulation. G protein-coupled receptor kinase 2 (GRK2) was…”
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A novel regulatory function of sweet taste-sensing receptor in adipogenic differentiation of 3T3-L1 cells by Masubuchi, Yosuke, Nakagawa, Yuko, Ma, Jinhui, Sasaki, Tsutomu, Kitamura, Tadahiro, Yamamoto, Yoritsuna, Kurose, Hitoshi, Kojima, Itaru, Shibata, Hiroshi

“…Sweet taste receptor is expressed not only in taste buds but also in nongustatory organs such as enteroendocrine cells and pancreatic beta-cells, and may play…”
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Knockout of Purinergic P2Y6 Receptor Fails to Improve Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis by Nishiyama, Kazuhiro, Ariyoshi, Kohei, Nishimura, Akiyuki, Kato, Yuri, Mi, Xinya, Kurose, Hitoshi, Kim, Sang Geon, Nishida, Motohiro

“…Nonalcoholic steatohepatitis (NASH) is a disease that progresses from nonalcoholic fatty liver (NAFL) and which is characterized by inflammation and fibrosis…”
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Gα12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration by Kim, Tae Hyun, Yang, Yoon Mee, Han, Chang Yeob, Koo, Ja Hyun, Oh, Hyunhee, Kim, Su Sung, You, Byoung Hoon, Choi, Young Hee, Park, Tae-Sik, Lee, Chang Ho, Kurose, Hitoshi, Noureddin, Mazen, Seki, Ekihiro, Wan, Yu-Jui Yvonne, Choi, Cheol Soo, Kim, Sang Geon

“…Nonalcoholic fatty liver disease (NAFLD) arises from mitochondrial dysfunction under sustained imbalance between energy intake and expenditure, but the…”
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Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound by Kiyonaka, Shigeki, Kato, Kenta, Nishida, Motohiro, Mio, Kazuhiro, Numaga, Takuro, Sawaguchi, Yuichi, Yoshida, Takashi, Wakamori, Minoru, Mori, Emiko, Numata, Tomohiro, Ishii, Masakazu, Takemoto, Hiroki, Ojida, Akio, Watanabe, Kenta, Uemura, Aya, Kurose, Hitoshi, Morii, Takashi, Kobayashi, Tsutomu, Sato, Yoji, Sato, Chikara, Hamachi, Itaru, Mori, Yasuo

“…Canonical transient receptor potential (TRPC) channels control influxes of Ca²⁺ and other cations that induce diverse cellular processes upon stimulation of…”
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β-arrestin2 in infiltrated macrophages inhibits excessive inflammation after myocardial infarction by Watari, Kenji, Nakaya, Michio, Nishida, Motohiro, Kim, Kyeong-Man, Kurose, Hitoshi

“…Beta-arrestins (β-arrestin1 and β-arrestin2) are known as cytosolic proteins that mediate desensitization and internalization of activated G protein-coupled…”
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Drebrin is induced during myofibroblast differentiation and enhances the production of fibrosis-related genes by Hironaka, Takanori, Ueno, Tomoyuki, Mae, Kyosuke, Yoshimura, Chikashi, Morinaga, Takumi, Horii, Yuma, Nagasaka, Akiomi, Kurose, Hitoshi, Nakaya, Michio

“…Fibrosis is attributed to excess deposition of extracellular matrix (ECM) proteins including collagen and is associated with various organ dysfunction. This…”
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TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy by Onohara, Naoya, Nishida, Motohiro, Inoue, Ryuji, Kobayashi, Hiroyuki, Sumimoto, Hideki, Sato, Yoji, Mori, Yasuo, Nagao, Taku, Kurose, Hitoshi

“…Angiotensin (Ang) II participates in the pathogenesis of heart failure through induction of cardiac hypertrophy. Ang II‐induced hypertrophic growth of…”
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