Search Results - "Hitora, Yuki"

Colletofragarone A2 and Colletoins A–C from a Fungus Colletotrichum sp. Decrease Mutant p53 Levels in Cells by Sadahiro, Yusaku, Hitora, Yuki, Tsukamoto, Sachiko

“…p53 is frequently mutated in tumor cells. Mutant p53 (mut p53) accumulates in cells to promote cancer progression, invasion, and metastasis, and it is…”
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Halichonic Acid B, a Rearranged Nitrogenous Bisabolene-Type Sesquiterpene from a Marine Sponge Axinyssa sp by Hitora, Yuki, Ogura, Kenta, El-Desoky, Ahmed H. H., Ise, Yuji, Angkouw, Esther D., Mangindaan, Remy E. P., Tsukamoto, Sachiko

“…A new rearranged nitrogenous bisabolone-type sesquiterpene, halichonic acid B (1), was isolated from a marine sponge Axinyssa sp. together with halichonic acid…”
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Cyclopsammocinamides A and B, Enantiomeric Cyclic Peptides of Cyclocinamide A, from the Marine Sponge Psammocinia sp by El-Desoky, Ahmed H. H., Hitora, Yuki, Onodera, Keita, Ise, Yuji, Losung, Fitje, Mangindaan, Remy E. P., Tsukamoto, Sachiko

“…LC-MS and molecular networking analyses of the extract of the marine sponge Psammocinia sp. indicated the presence of two new compounds with multiple halogens…”
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A monoacylglyceryltrimethylhomoserine, 21F121-A, containing a branched acyl group from Penicillium glaucoroseum by Kimura, Ichiro, Hitora, Yuki, Sadahiro, Yusaku, Kawahara, Teppei, Tsukamoto, Sachiko

“…A new monoacylglyceryltrimethylhomoserine, 21F121-A ( 1 ), was isolated from the culture of Penicillium glaucoroseum (21F00121) by LCMS-guided purification…”
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Peniphilones A and B: Azaphilone Alkaloids from the Endophytic Fungus Penicillium maximae by Tsukamoto, Sachiko, Koyanagi, Yuhei, Hitora, Yuki

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Induction of secondary metabolite production by fungal co-culture of Talaromyces pinophilus and Paraphaeosphaeria sp by Murakami, Shunya, Hayashi, Nozomu, Inomata, Teruyo, Kato, Hikaru, Hitora, Yuki, Tsukamoto, Sachiko

“…Fungal co-culture is a strategy to induce the production of secondary metabolites by activating cryptic genes. We discovered the production of a new compound,…”
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Colletofragarone A2 Inhibits Cancer Cell Growth In Vivo and Leads to the Degradation and Aggregation of Mutant p53 by Sadahiro, Yusaku, Hitora, Yuki, Kimura, Ichiro, Hitora-Imamura, Natsuko, Onodera, Risako, Motoyama, Keiichi, Tsukamoto, Sachiko

“…Mutant p53 not only loses its original tumor suppressor function but also acquires new abilities regarding oncogenic progression. Therefore, the strategy of…”
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A new linear peptide, higapeptin, isolated from the mud flat-derived fungus Acremonium persicinum inhibits mitochondrial energy metabolism by El-Desoky, Ahmed H., Hitora, Yuki, Nishime, Yoshitomo, Sadahiro, Yusaku, Kawahara, Teppei, Tsukamoto, Sachiko

“…A combination of LC–MS/MS and feature-based molecular networking analyses led to the isolation of a new adenopeptin analog, higapeptin ( 1 ), and four known…”
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Synthesis and Biological Evaluation of Siladenoserinol A Analogs Possessing a Diastereomeric 6,8-Dioxabicyclo[3.2.1]octane Skeleton by Yoshida, Masahito, Sasaoka, Kohei, Hano, Kohei, Sugiyama, Yoshiyuki, Hitora, Yuki, Doi, Takayuki, Tsukamoto, Sachiko, Kigoshi, Hideo

“…The efficient synthesis of siladenoserinol analogs possessing a diastereomeric 6,8-dioxabicyclo[3.2.1]octane (6,8-DOBCO) skeleton has been achieved from…”
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Dragmacidins G and H, Bisindole Alkaloids Tethered by a Guanidino Ethylthiopyrazine Moiety, from a Lipastrotethya sp. Marine Sponge by Hitora, Yuki, Takada, Kentaro, Ise, Yuji, Okada, Shigeru, Matsunaga, Shigeki

“…LCMS analysis of the extract and a cytotoxicity assay of the HPLC fractions generated from a small-scale extract of a Lipastrotethya sp. marine sponge…”
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Arteperoxides A–C, tris-normonoterpene–sesquiterpene conjugates with peroxide-bridges from Artemisia judaica exhibiting antiosteoclastogenic activity by El-Desoky, Ahmed H., Asano, Toshifumi, Maeyama, Yuka, Kato, Hikaru, Hitora, Yuki, Goto, Eishu, Kotani, Shunsuke, Nakajima, Makoto, Tsukamoto, Sachiko

“…Antiosteoclastogenic-guided screening was conducted with 120 extracts of the medicinal plants collected in Egypt that led to the selection of Artemisia judaica…”
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Cell-based screening of extracts of natural sources to search for inhibitors of the ubiquitin–proteasome system and identification of proteasome inhibitors from the fungus Remotididymella sp by Nishimura, Soichiro, Hitora, Yuki, Kawahara, Teppei, Tanabe, Mika, Ogata, Eisuke, Kato, Hikaru, Srikoon, Pattaravadee, Watanabe, Takashi, Tsukamoto, Sachiko

“…[Display omitted] •We screened fungal extracts using a cell-based luminescent assay.•This assay can exclude influences of coloring or fluorescent compounds in…”
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Isolation, Synthesis, and Structure–Activity Relationship Study on Daphnane and Tigliane Diterpenes as HIV Latency-Reversing Agents by El-Desoky, Ahmed H. H, Eguchi, Keisuke, Kishimoto, Naoki, Asano, Toshifumi, Kato, Hikaru, Hitora, Yuki, Kotani, Shunsuke, Nakamura, Teruya, Tsuchiya, Soken, Kawahara, Teppei, Watanabe, Masato, Wada, Mikiyo, Nakajima, Makoto, Watanabe, Takashi, Misumi, Shogo, Tsukamoto, Sachiko

“…Three new diterpenes, stellejasmins A (1) and B (2) and 12-O-benzoylphorbol-13-heptanoate (3), were isolated from the roots of Stellera chamaejasme L. The…”
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Poecillastrin E, F, and G, cytotoxic chondropsin-type macrolides from a marine sponge Poecillastra sp by Irie, Raku, Hitora, Yuki, Ise, Yuji, Okada, Shigeru, Takada, Kentaro, Matsunaga, Shigeki

“…Poecillastrin E (1), F (2), and G (3) were isolated from a marine sponge Poecillastra sp. as the cytotoxic constituents. Their planar structures were…”
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Combinatorial screening for therapeutics in ATTRv amyloidosis identifies naphthoquinone analogues as TTR-selective amyloid disruptors by Sasaki, Ryoko, Suico, Mary Ann, Chosa, Keisuke, Teranishi, Yuriko, Sato, Takashi, Kagami, Asuka, Kotani, Shunsuke, Kato, Hikaru, Hitora, Yuki, Tsukamoto, Sachiko, Yamashita, Tomohiro, Yokoyama, Takeshi, Mizuguchi, Mineyuki, Kai, Hirofumi, Shuto, Tsuyoshi

“…Hereditary ATTR amyloidosis is caused by the point mutation in serum protein transthyretin (TTR) that destabilizes its tetrameric structure to dissociate into…”
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Fluorescent image-based high-content screening of extracts of natural resources for cell cycle inhibitors and identification of a new sesquiterpene quinone from the sponge, Dactylospongia metachromia by Hitora, Yuki, Sejiyama, Ai, Honda, Koyo, Ise, Yuji, Losung, Fitje, Mangindaan, Remy E.P., Tsukamoto, Sachiko

“…[Display omitted] •We constructed a screening system for isolating cell cycle inhibitors.•It is a fluorescent image-based high-content system using HeLa/Fucci2…”
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Amakusamine from a Psammocinia sp. Sponge: Isolation, Synthesis, and SAR Study on the Inhibition of RANKL-Induced Formation of Multinuclear Osteoclasts by Maeyama, Yuka, Nakashima, Yuta, Kato, Hikaru, Hitora, Yuki, Maki, Kazuhiko, Inada, Natsumi, Murakami, Shunya, Inazumi, Tomoaki, Ise, Yuji, Sugimoto, Yukihiko, Ishikawa, Hayato, Tsukamoto, Sachiko

“…A simple methylenedioxy dibromoindole alkaloid, amakusamine (1), was isolated from a marine sponge of the genus Psammocinia, and its structure was determined…”
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Taichunins E–T, Isopimarane Diterpenes and a 20-nor-Isopimarane, from Aspergillus taichungensis (IBT 19404): Structures and Inhibitory Effects on RANKL-Induced Formation of Multinuclear Osteoclasts by El-Desoky, Ahmed H. H, Inada, Natsumi, Maeyama, Yuka, Kato, Hikaru, Hitora, Yuki, Sebe, Momona, Nagaki, Mika, Kai, Aika, Eguchi, Keisuke, Inazumi, Tomoaki, Sugimoto, Yukihiko, Frisvad, Jens C, Williams, Robert M, Tsukamoto, Sachiko

“…Fifteen new isopimarane-type diterpenes, taichunins E–S (1–15), and a new 20-nor-isopimarane, taichunin T (16), together with four known compounds were…”
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On the assignment of the absolute configuration at the isolated methyl branch in miyakosyne A, cytotoxic linear acetylene, from the deep-sea marine sponge Petrosia sp by Hitora, Yuki, Takada, Kentaro, Matsunaga, Shigeki

“…Absolute configuration of miyakosyne A at its isolated branched methyl stereogenic center has been studied by chemical degradation in combination with…”
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Curacin E from the Brittle Star Ophiocoma scolopendrina by Ueoka, Reiko, Hitora, Yuki, Ito, Akihiro, Yoshida, Minoru, Okada, Shigeru, Takada, Kentaro, Matsunaga, Shigeki

“…Bioassay-guided fractionation of the extract of the brittle star Ophiocoma scolopendrina afforded curacin E (1), a congener of curacin A (2). Curacin A (2) is…”
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