Search Results - "Hite, Richard"

Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel by Tao, Xiao, Hite, Richard K., MacKinnon, Roderick

“…The Ca 2+ -activated K + channel, Slo1, has an unusually large conductance and contains a voltage sensor and multiple chemical sensors. Dual activation by…”
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Structural basis for the regulation of inositol trisphosphate receptors by Ca2+ and IP3 by Paknejad, Navid, Hite, Richard K.

“…Inositol trisphosphate receptors (IP 3 Rs) are ubiquitous Ca 2+ -permeable channels that mediate release of Ca 2+ from the endoplasmic reticulum, thereby…”
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Structural Titration of Slo2.2, a Na+-Dependent K+ Channel by Hite, Richard K., MacKinnon, Roderick

“…The stable structural conformations that occur along the complete reaction coordinate for ion channel opening have never been observed. In this study, we…”
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Structural basis for gating the high-conductance Ca2+-activated K+ channel by Hite, Richard K., Tao, Xiao, MacKinnon, Roderick

“…The precise control of an ion channel gate by environmental stimuli is crucial for the fulfilment of its biological role. The gate in Slo1 K + channels is…”
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Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms by Deng, Zengqin, Paknejad, Navid, Maksaev, Grigory, Sala-Rabanal, Monica, Nichols, Colin G., Hite, Richard K., Yuan, Peng

“…The transient receptor potential (TRP) channel TRPV4 participates in multiple biological processes, and numerous TRPV4 mutations underlie several distinct and…”
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Cryo-electron microscopy structure of the Slo2.2 Na+-activated K+ channel by Hite, Richard K., Yuan, Peng, Li, Zongli, Hsuing, Yichun, Walz, Thomas, MacKinnon, Roderick

“…Na + -activated K + channels are members of the Slo family of large conductance K + channels that are widely expressed in the brain, where their opening…”
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Structural titration reveals Ca2+-dependent conformational landscape of the IP3 receptor by Paknejad, Navid, Sapuru, Vinay, Hite, Richard K.

“…Inositol 1,4,5-trisphosphate receptors (IP 3 Rs) are endoplasmic reticulum Ca 2+ channels whose biphasic dependence on cytosolic Ca 2+ gives rise to Ca 2+…”
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Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1 by Schrecker, Marina, Korobenko, Julia, Hite, Richard K

“…The chloride-proton exchanger CLC-7 plays critical roles in lysosomal homeostasis and bone regeneration and its mutation can lead to osteopetrosis, lysosomal…”
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Mechanisms of loading and release of the 9-1-1 checkpoint clamp by Castaneda, Juan C., Schrecker, Marina, Remus, Dirk, Hite, Richard K.

“…Single-stranded or double-stranded DNA junctions with recessed 5′ ends serve as loading sites for the checkpoint clamp, 9-1-1, which mediates activation of the…”
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Membrane-mediated protein interactions drive membrane protein organization by Jiang, Yining, Thienpont, Batiste, Sapuru, Vinay, Hite, Richard K., Dittman, Jeremy S., Sturgis, James N., Scheuring, Simon

“…The plasma membrane’s main constituents, i.e., phospholipids and membrane proteins, are known to be organized in lipid-protein functional domains and…”
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Structural titration of receptor ion channel GLIC gating by HS-AFM by Ruan, Yi, Kao, Kevin, Lefebvre, Solène, Marchesi, Arin, Corringer, Pierre-Jean, Hite, Richard K., Scheuring, Simon

“…Gloeobacter violaceus ligand-gated ion channel (GLIC), a proton-gated, cation-selective channel, is a prokaryotic homolog of the pentameric Cys-loop receptor…”
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Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate by Liu, Shian, Paknejad, Navid, Zhu, Lan, Kihara, Yasuyuki, Ray, Manisha, Chun, Jerold, Liu, Wei, Hite, Richard K., Huang, Xin-Yun

“…Lysophospholipids are bioactive lipids and can signal through G-protein-coupled receptors (GPCRs). The best studied lysophospholipids are lysophosphatidic acid…”
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Principles of membrane protein interactions with annular lipids deduced from aquaporin-0 2D crystals by Hite, Richard K, Li, Zongli, Walz, Thomas

“…We have previously described the interactions of aquaporin‐0 (AQP0) with dimyristoyl phosphatidylcholine (DMPC) lipids. We have now determined the 2.5 Å…”
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Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1 by Son, Yeeun, Kenny, Timothy C., Khan, Artem, Birsoy, Kıvanç, Hite, Richard K.

“…Phosphatidylcholine and phosphatidylethanolamine, the two most abundant phospholipids in mammalian cells, are synthesized de novo by the Kennedy pathway from…”
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Discovery of Selective Inhibitors for the Lysosomal Parkinson’s Disease Channel TMEM175 by Oh, SeCheol, Lee, Jooyeon, Choi, Ho Jeong, Kim, Songwon, Sapuru, Vinay, Kim, Min, Hite, Richard K.

“…TMEM175 is a lysosomal potassium and proton channel that is associated with the development of Parkinson’s disease. Advances in understanding the physiological…”
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Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs by Kern, David M, Oh, SeCheol, Hite, Richard K, Brohawn, Stephen G

“…Hypoosmotic conditions activate volume-regulated anion channels in vertebrate cells. These channels are formed by leucine-rich repeat-containing protein 8…”
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Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β1-Adrenergic Receptor by Su, Minfei, Zhu, Lan, Zhang, Yixiao, Paknejad, Navid, Dey, Raja, Huang, Jianyun, Lee, Ming-Yue, Williams, Dewight, Jordan, Kelsey D., Eng, Edward T., Ernst, Oliver P., Meyerson, Joel R., Hite, Richard K., Walz, Thomas, Liu, Wei, Huang, Xin-Yun

“…Cardiac disease remains the leading cause of morbidity and mortality worldwide. The β1-adrenergic receptor (β1-AR) is a major regulator of cardiac functions…”
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A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter by Oldham, Michael L., Hite, Richard K., Steffen, Alanna M., Damko, Ermelinda, Li, Zongli, Walz, Thomas, Chen, Jue

“…The cryo-electron microscopy structure of human TAP transporter, a peptide transporter central to MHC class I antigen presentation and cellular immunity, in…”
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SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells by Wang, Ying, Yen, Frederick S., Zhu, Xiphias Ge, Timson, Rebecca C., Weber, Ross, Xing, Changrui, Liu, Yuyang, Allwein, Benjamin, Luo, Hanzhi, Yeh, Hsi-Wen, Heissel, Søren, Unlu, Gokhan, Gamazon, Eric R., Kharas, Michael G., Hite, Richard, Birsoy, Kıvanç

“…Glutathione (GSH) is a small-molecule thiol that is abundant in all eukaryotes and has key roles in oxidative metabolism 1 . Mitochondria, as the major site of…”
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Mechanism of 4-aminopyridine inhibition of the lysosomal channel TMEM175 by Oh, SeCheol, Stix, Robyn, Zhou, Wenchang, Faraldo-Gómez, José D, Hite, Richard K

“…Transmembrane protein 175 (TMEM175) is an evolutionarily distinct lysosomal cation channel whose mutation is associated with the development of Parkinson's…”
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