Search Results - "Hitchen, Paul G"

Mass spectrometry in the analysis of N-linked and O-linked glycans by North, Simon J, Hitchen, Paul G, Haslam, Stuart M, Dell, Anne

“…Mass spectrometry (MS) continues to play a vital role in defining the structures of N-glycans and O-glycans in glycoproteins via glycomic and glycoproteomic…”
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Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities by Silva, John-Paul, Lelianova, Vera G, Ermolyuk, Yaroslav S, Vysokov, Nickolai, Hitchen, Paul G, Berninghausen, Otto, Rahman, M. Atiqur, Zangrandi, Alice, Fidalgo, Sara, Tonevitsky, Alexander G, Dell, Anne, Volynski, Kirill E, Ushkaryov, Yuri A

“…Latrophilin 1 (LPH1), a neuronal receptor of α-latrotoxin, is implicated in neurotransmitter release and control of presynaptic Ca²⁺. As an "adhesion…”
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Engineering N-Linked Protein Glycosylation with Diverse O Antigen Lipopolysaccharide Structures in Escherichia coli by Feldman, Mario F., Wacker, Michael, Hernandez, Marcela, Hitchen, Paul G., Marolda, Cristina L., Kowarik, Michael, Morris, Howard R., Dell, Anne, Valvano, Miguel A., Aebi, Markus, Parodi, Armando J.

“…Campylobacter jejuni has a general N-linked protein glycosylation system that can be functionally transferred to Escherichia coli. In this study, we engineered…”
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Glycoproteomic studies of IgE from a novel hyper IgE syndrome linked to PGM3 mutation by Wu, Gang, Hitchen, Paul G., Panico, Maria, North, Simon J., Barbouche, Mohamed-Ridha, Binet, Daniel, Morris, Howard R., Dell, Anne, Haslam, Stuart M.

“…Glycans serve as important regulators of antibody activities and half-lives. IgE is the most heavily glycosylated antibody, but in comparison to other…”
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AglJ Adds the First Sugar of the N-Linked Pentasaccharide Decorating the Haloferax volcanii S-Layer Glycoprotein by KAMINSKI, Lina, ABU-QARN, Mehtap, ZIQIANG GUAN, NAPARSTEK, Shai, VENTURA, Valeria V, RAETZ, Christian R. H, HITCHEN, Paul G, DELL, Anne, EICHLER, Jerry

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Functional analysis of the Campylobacter jejuni N‐linked protein glycosylation pathway by Linton, Dennis, Dorrell, Nick, Hitchen, Paul G., Amber, Saba, Karlyshev, Andrey V., Morris, Howard R., Dell, Anne, Valvano, Miguel A., Aebi, Markus, Wren, Brendan W.

“…Summary We describe in this report the characterization of the recently discovered N‐linked glycosylation locus of the human bacterial pathogen Campylobacter…”
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Targeted glycoproteomic identification of cancer cell glycosylation by Powlesland, Alex S, Hitchen, Paul G, Parry, Simon, Graham, Sarah A, Barrio, Maria Marcela, Elola, Maria Teresa, Mordoh, José, Dell, Anne, Drickamer, Kurt, Taylor, Maureen E

“…GalMBP is a fragment of serum mannose-binding protein that has been modified to create a probe for galactose-containing ligands. Glycan array screening…”
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Identification of AglE, a Second Glycosyltransferase Involved in N Glycosylation of the Haloferax volcanii S-Layer Glycoprotein by Abu-Qarn, Mehtap, Giordano, Assunta, Battaglia, Francesca, Trauner, Andrej, Hitchen, Paul G, Morris, Howard R, Dell, Anne, Eichler, Jerry

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Deletion of Cg-emb in Corynebacterianeae Leads to a Novel Truncated Cell Wall Arabinogalactan, whereas Inactivation of Cg-ubiA Results in an Arabinan-deficient Mutant with a Cell Wall Galactan Core by Alderwick, Luke J., Radmacher, Eva, Seidel, Mathias, Gande, Roland, Hitchen, Paul G., Morris, Howard R., Dell, Anne, Sahm, Hermann, Eggeling, Lothar, Besra, Gurdyal S.

“…The cell wall of Mycobacterium tuberculosis has a complex ultrastructure that consists of mycolic acids connected to peptidoglycan via arabinogalactan (AG) and…”
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Bacterial glycoproteomics by Hitchen, Paul G, Dell, Anne

“…Division of Molecular Biosciences, Faculty of Natural Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK Correspondence Paul G…”
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The Tip of Brucella O-Polysaccharide Is a Potent Epitope in Response to Brucellosis Infection and Enables Short Synthetic Antigens to Be Superior Diagnostic Reagents by Duncombe, Lucy, Howells, Laurence, Haughey, Anna, Taylor, Andrew V, Kaveh, Daryan, Erdenliğ Gϋrbilek, Sevil, Dell, Anne, Hitchen, Paul G, Haslam, Stuart M, Mandal, Satadru Sekhar, Ganesh, N Vijaya, Bundle, David R, McGiven, John

“…Brucellosis is a global disease and the world's most prevalent zoonosis. All cases in livestock and most cases in humans are caused by members of the genus…”
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The Immunologically Distinct O Antigens from Francisella tularensis Subspecies tularensis and Francisella novicida Are both Virulence Determinants and Protective Antigens by THOMAS, Rebecca M, TITBALL, Richard W, OYSTON, Petra C. F, GRIFFIN, Kate, WATERS, Emma, HITCHEN, Paul G, MICHELL, Stephen L, DARREN GRICE, I, WILSON, Jennifer C, PRIOR, Joann L

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An Aeromonas caviae Genomic Island Is Required for both O-Antigen Lipopolysaccharide Biosynthesis and Flagellin Glycosylation by TABEI, S. Mohammed B, HITCHEN, Paul G, DELL, Anne, SHAW, Jonathan G, DAY-WILLIAMS, Michaela J, MERINO, Susana, VART, Richard, PANG, Poh-Choo, HORSBURGH, Gavin J, VICHES, Silvia, WILHELMS, Markus, TOMAS, Juan M

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Glycoproteomics: a powerful tool for characterizing the diverse glycoforms of bacterial pilins and flagellins by Hitchen, Paul G, Twigger, Katie, Valiente, Esmeralda, Langdon, Rebecca H, Wren, Brendan W, Dell, Anne

“…With glycosylation now firmly established across both Archaeal and bacterial proteins, a wide array of glycan diversity has become evident from structural…”
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Gene Function Hypotheses for the Campylobacter jejuni Glycome Generated by a Logic-Based Approach by Sternberg, Michael J.E., Tamaddoni-Nezhad, Alireza, Lesk, Victor I., Kay, Emily, Hitchen, Paul G., Cootes, Adrian, van Alphen, Lieke B., Lamoureux, Marc P., Jarrell, Harold C., Rawlings, Christopher J., Soo, Evelyn C., Szymanski, Christine M., Dell, Anne, Wren, Brendan W., Muggleton, Stephen H.

“…Increasingly, experimental data on biological systems are obtained from several sources and computational approaches are required to integrate this information…”
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The S-Layer Glycoprotein of the Crenarchaeote Sulfolobus acidocaldarius Is Glycosylated at Multiple Sites with Chitobiose-Linked N-Glycans by Peyfoon, Elham, Meyer, Benjamin, Hitchen, Paul G., Panico, Maria, Morris, Howard R., Haslam, Stuart M., Albers, Sonja-Verena, Dell, Anne

“…Glycosylation of the S-layer of the crenarchaea Sulfolobus acidocaldarius has been investigated using glycoproteomic methodologies. The mature protein is…”
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Neisseria gonorrhoeae Type IV Pili Undergo Multisite, Hierarchical Modifications with Phosphoethanolamine and Phosphocholine Requiring an Enzyme Structurally Related to Lipopolysaccharide Phosphoethanolamine Transferases by Aas, Finn Erik, Egge-Jacobsen, Wolfgang, Winther-Larsen, Hanne C., Løvold, Cecilia, Hitchen, Paul G., Dell, Anne, Koomey, Michael

“…The zwitterionic phospho-forms phosphoethanolamine and phosphocholine are recognized as influential and important substituents of pathogen cell surfaces. PilE,…”
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Unique Modifications with Phosphocholine and Phosphoethanolamine Define Alternate Antigenic Forms of Neisseria gonorrhoeae Type IV pili by Hegge, Finn Terje, Hitchen, Paul G., Aas, Finn Erik, Kristiansen, Heidi, Løvold, Cecilia, Egge-Jacobsen, Wolfgang, Panico, Maria, Leong, Weng Yee, Bull, Victoria, Virji, Mumtaz, Morris, Howard R., Dell, Anne, Koomey, Michael, Mekalanos, John J.

“…Several major bacterial pathogens and related commensal species colonizing the human mucosa express phosphocholine (PC) at their cell surfaces. PC appears to…”
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LosA, a Key Glycosyltransferase Involved in the Biosynthesis of a Novel Family of Glycosylated Acyltrehalose Lipooligosaccharides from Mycobacterium marinum by Burguière, Adeline, Hitchen, Paul G., Dover, Lynn G., Kremer, Laurent, Ridell, Malin, Alexander, David C., Liu, Jun, Morris, Howard R., Minnikin, David E., Dell, Anne, Besra, Gurdyal S.

“…Members of the genus Mycobacterium are characterized by cell envelopes rich in unusual free lipids, interacting with a covalently anchored…”
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Systems analysis of bacterial glycomes by Kay, Emily, Lesk, Victor I, Tamaddoni-Nezhad, Alireza, Hitchen, Paul G, Dell, Anne, Sternberg, Michael J, Muggleton, Stephen, Wren, Brendan W

“…Bacteria produce an array of glycan-based structures including capsules, lipo-oligosaccharide and glycosylated proteins, which are invariably…”
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