Search Results - "Hitchcock, M J"

Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates by Chang, Zongliang, Qin, Weibing, Zheng, Huili, Schegg, Kathleen, Han, Lu, Liu, Xiaohua, Wang, Yue, Wang, Zhuqing, McSwiggin, Hayden, Peng, Hongying, Yuan, Shuiqiao, Wu, Jiabao, Wang, Yongxia, Zhu, Shenghui, Jiang, Yanjia, Nie, Hua, Tang, Yuan, Zhou, Yu, Hitchcock, Michael J. M., Tang, Yunge, Yan, Wei

“…There are no non-hormonal male contraceptives currently on the market despite decades of efforts toward the development of “male pills”. Here, we report that…”
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Assessment of Mitochondrial Toxicity in Human Cells Treated with Tenofovir: Comparison with Other Nucleoside Reverse Transcriptase Inhibitors by BIRKUS, Gabriel, HITCHCOCK, Michael J. M, CIHLAR, Tomas

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Evidence of Oxidative Stress and Associated DNA Damage, Increased Proliferative Drive, and Altered Gene Expression in Rat Liver Produced by the Cholangiocarcinogenic Agent Furan by Hickling, K. C., Hitchcock, J. M., Oreffo, V., Mally, A., Hammond, T. G., Evans, J. G., Chipman, J. K.

“…Furan is a potent cholangiocarcinogen in rat by an as yet undefined mechanism. The risk to man remains unclear. Using a time-course stop study design, we have…”
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Induction and Progression of Cholangiofibrosis in Rat Liver Injured by Oral Administration of Furan by Hickling, K. C., Hitchcock, J. M., Chipman, J. K., Hammond, T. G., Evans, J. G.

“…Cholangiofibrosis is a structural anomaly that precedes the development of cholangiocarcinoma in some rodent models. In this article, the authors examine the…”
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Evaluation of Nucleoside Phosphonates and Their Analogs and Prodrugs for Inhibition of Orthopoxvirus Replication by KEITH, Kathy A, HITCHCOCK, Michael J. M, LEE, William A, HOLY, Antonin, KERN, Earl R

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On the effect of neonatal nitric oxide synthase inhibition in rats: a potential neurodevelopmental model of schizophrenia by Black, Mark D., Selk, David E., Hitchcock, J.M., Wettstein, Joseph G., Sorensen, Stephen M.

“…NADPH-d (nicotinamide-adenine dinucleotide phosphate-diaphorase) neurons are thought to migrate improperly during development in the brains of schizophrenic…”
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Tenofovir alafenamide: A novel prodrug of tenofovir for the treatment of Human Immunodeficiency Virus by Ray, Adrian S., Fordyce, Marshall W., Hitchcock, Michael J.M.

“…Despite substantial progress in the development of antiretroviral regimens that durably suppress Human Immunodeficiency Virus (HIV) infection, new agents that…”
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Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients by CUNDY, K. C, PETTY, B. G, FLAHERTY, J, FISHER, P. E, POLIS, M. A, WACHSMAN, M, LIETMAN, P. S, LALEZARI, J. P, HITCHCOCK, M. J. M, JAFFE, H. S

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Efferent Pathway of the Amygdala Involved in Conditioned Fear as Measured With the Fear-Potentiated Startle Paradigm by Hitchcock, Janice M, Davis, Michael

“…Fear-potentiated startle in the rat is a measure of conditioned fear that is blocked by lesions of the central nucleus of the amygdala. In a companion study,…”
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Lesions of the perirhinal cortex but not of the frontal, medial prefrontal, visual, or insular cortex block fear-potentiated startle using a visual conditioned stimulus by Rosen, JB, Hitchcock, JM, Miserendino, MJ, Falls, WA, Campeau, S, Davis, M

“…The present study is part of an ongoing series of experiments aimed at delineation of the neural pathways that mediate fear-potentiated startle, a model of…”
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Early nucleoside reverse transcriptase inhibitors for the treatment of HIV: A brief history of stavudine (D4T) and its comparison with other dideoxynucleosides by Martin, John C., Hitchcock, Michael J.M., De Clercq, Erik, Prusoff, William H.

“…The occasion of this 25th anniversary issue encouraged us to reminisce about the important history of the discovery of the dideoxynucleoside analogues for the…”
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Synthesis, Oral Bioavailability Determination, and in vitro Evaluation of Prodrugs of the Antiviral Agent 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) by Starrett, John E. Jr, Tortolani, David R, Russell, John, Hitchcock, Michael J. M, Whiterock, Valerie, Martin, John C, Mansuri, Muzammil M

“…A series of phosphonate prodrugs were evaluated in an attempt to increase the oral bioavailability of the anti-HIV agent 9-[2-(phosphonomethoxy)ethyl]adenine…”
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Effect of Oral Probenecid Coadministration on the Chronic Toxicity and Pharmacokinetics of Intravenous Cidofovir in Cynomolgus Monkeys by Lacy, Steven A., Hitchcock, Michael J. M., Lee, William A., Tellier, Pierre, Cundy, Kenneth C.

“…In animals and humans, intravenous administration of the antiviral nucleotide analogue cidofovir results in a dose-limiting nephrotoxicity characterized by…”
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Cellular pharmacology of 2',3'-dideoxy-2',3'-didehydrothymidine, a nucleoside analog active against human immunodeficiency virus by HSU-TSO HO, HITCHCOCK, M. J. M

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Intracellular metabolism of the antiherpes agent (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine by Ho, H T, Woods, K L, Bronson, J J, De Boeck, H, Martin, J C, Hitchcock, M J

“…(S)-1-[3-Hydroxy-2-(phosphonylmethoxy)propyl]cytosine (HPMPC) is an antiviral phosphonate nucleotide analogue that displays activity against a range of…”
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Acyclic purine phosphonate analogs as antiviral agents. Synthesis and structure-activity relationships by Kim, Choung Un, Luh, Bing Yu, Misco, Peter F, Bronson, Joanne J, Hitchcock, Michael J. M, Ghazzouli, Ismail, Martin, John C

“…A series of 9-(phosphonoalkyl)purines, which are analogues of 9-[2-(phosphonomethoxy)ethyl]purines (guanine, PMEG, 1; adenine, PMEA, 2), were synthesized. The…”
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A Direct Projection From the Central Nucleus of the Amygdala to the Acoustic Startle Pathway: Anterograde and Retrograde Tracing Studies by Rosen, Jeffrey B, Hitchcock, Janice M, Sananes, Catherine B, Miserendino, Mindy J. D, Davis, Michael

“…Previous work has shown that lesions of the central nucleus of the amygdala block fear-potentiated acoustic startle and that electrical simulation of the…”
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Dissipative transport of a Bose-Einstein condensate by Dries, D., Pollack, S. E., Hitchcock, J. M., Hulet, R. G.

“…We investigate the effects of impurities, either correlated disorder or a single Gaussian defect, on the collective dipole motion of a Bose-Einstein condensate…”
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All-optical production of a lithium quantum gas using narrow-line laser cooling by Duarte, P. M., Hart, R. A., Hitchcock, J. M., Corcovilos, T. A., Yang, T.-L., Reed, A., Hulet, R. G.

“…We have used the narrow 2S{sub 1/2}{yields}3P{sub 3/2} transition in the ultraviolet (uv) to laser cool and magneto-optically trap (MOT) {sup 6}Li atoms. Laser…”
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Disruption of latent inhibition in the rat by the 5-HT2 agonist DOI: effects of MDL 100,907, clozapine, risperidone and haloperidol by HITCHCOCK, J. M, LISTER, S, FISCHER, T. R, WETTSTEIN, J. G

“…Latent inhibition (LI), a measure of the ability to learn to ignore irrelevant stimuli, is disrupted in acute schizophrenics and in rats treated with…”
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