Search Results - "Hislop, AD"

Lamp-2a Facilitates MHC Class II Presentation of Cytoplasmic Antigens by Zhou, Delu, Li, Ping, Lin, Yinling, Lott, Jeremy M., Hislop, Andrew D., Canaday, David H., Brutkiewicz, Randy R., Blum, Janice S.

“…Extracellular antigens are internalized and processed before binding MHC class II molecules within endosomal and lysosomal compartments of professional antigen…”
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Epitope-specific evolution of human CD8(+) T cell responses from primary to persistent phases of Epstein-Barr virus infection by Hislop, Andrew D, Annels, Nicola E, Gudgeon, Nancy H, Leese, Alison M, Rickinson, Alan B

“…Primary virus infection often elicits a large CD8(+) T cell response which subsequently contracts to a smaller memory T cell pool; the relationship between…”
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Increased Expression of the NK Cell Receptor KLRG1 by Virus-Specific CD8 T Cells during Persistent Antigen Stimulation by THIMME, Robert, APPAY, Victor, KOSCHELLA, Marie, PANTHER, Elisabeth, ROTH, Evelyn, HISLOP, Andrew D, RICKINSON, Alan B, ROWLAND-JONES, Sarah L, BLUM, Hubert E, PIRCHER, Hanspeter

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CD8+ immunodominance among Epstein-Barr virus lytic cycle antigens directly reflects the efficiency of antigen presentation in lytically infected cells by Pudney, Victoria A, Leese, Alison M, Rickinson, Alan B, Hislop, Andrew D

“…Antigen immunodominance is an unexplained feature of CD8+ T cell responses to herpesviruses, which are agents whose lytic replication involves the sequential…”
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A mutation in X‐linked inhibitor of apoptosis (G466X) leads to memory inflation of Epstein–Barr virus‐specific T cells by Lopez‐Granados, E., Stacey, M., Kienzler, A.‐K., Sierro, S., Willberg, C. B., Fox, C. P., Rigaud, S., Long, H. M., Hislop, A. D., Rickinson, A. B., Patel, S., Latour, S., Klenerman, P., Chapel, H.

“…Summary Mutations in the X‐linked inhibitor of apoptosis (XIAP) gene have been associated with XLP‐like disease, including recurrent Epstein–Barr virus…”
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CD8+ T cell immunity to Epstein-Barr virus and Kaposi’s sarcoma-associated herpes virus by Hislop, Andrew D, Sabbah, Shereen

“…Abstract Gammaherpesviruses are agents which have evolved to persist within the lymphoid system and many have oncogenic potential; studying gammaherpesvirus…”
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Tonsillar homing of Epstein-Barr virus-specific CD8+ T cells and the virus-host balance by Hislop, Andrew D, Kuo, Michael, Drake-Lee, Adrian B, Akbar, Arne N, Bergler, Wolfgang, Hammerschmitt, Nicolas, Khan, Naeem, Palendira, Umaimainthan, Leese, Alison M, Timms, Judith M, Bell, Andrew I, Buckley, Christopher D, Rickinson, Alan B

“…Patients with infectious mononucleosis (IM) undergoing primary EBV infection show large expansions of EBV-specific CD8+ T cells in the blood. While latent…”
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EBV-Specific CD8+ T Cell Memory: Relationships Between Epitope Specificity, Cell Phenotype, and Immediate Effector Function by Hislop, Andrew D, Gudgeon, Nancy H, Callan, Margaret F. C, Fazou, Chrysoula, Hasegawa, Hitoshi, Salmon, Michael, Rickinson, Alan B

“…EBV infection in humans induces CD8+ T cell memory to viral epitopes derived from both lytic and latent cycle Ags. We have analyzed the relationship between…”
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The T cell response to persistent herpes virus infections in common variable immunodeficiency by Raeiszadeh, M., Kopycinski, J., Paston, S. J., Diss, T., Lowdell, M., Hardy, G. A. D., Hislop, A. D., Workman, S., Dodi, A., Emery, V., Webster, A. D.

“…Summary We show that at least half of patients with common variable immunodeficiency (CVID) have circulating CD8+ T cells specific for epitopes derived from…”
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Epstein-Barr virus–specific CD8+ T cells that re-express CD45RA are apoptosis-resistant memory cells that retain replicative potential by Dunne, Padraic J., Faint, Jeffery M., Gudgeon, Nancy H., Fletcher, Jean M., Plunkett, Fiona J., Soares, Maria Vieira D., Hislop, Andrew D., Annels, Nicola E., Rickinson, Alan B., Salmon, Mike, Akbar, Arne N.

“…During acute infection, latent and lytic Epstein-Barr virus (EBV) epitope-specific CD8+ T cells have a CD45RO+CD45RA− phenotype. However, after resolution of…”
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Memory T Cells Constitute a Subset of the Human CD8+CD45RA+ Pool with Distinct Phenotypic and Migratory Characteristics by Faint, Jeffery M, Annels, Nicola E, Curnow, S. John, Shields, Philip, Pilling, Darrell, Hislop, Andrew D, Wu, Lijun, Akbar, Arne N, Buckley, Christopher D, Moss, Paul A. H, Adams, David H, Rickinson, Alan B, Salmon, Mike

“…Using HLA class I-viral epitope tetramers to monitor herpes virus-specific CD8(+) T cell responses in humans, we have shown that a significant fraction of…”
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The impact of telomere erosion on memory CD8 + T cells in patients with X-linked lymphoproliferative syndrome by Plunkett, Fiona J., Franzese, Ornella, Belaramani, Lavina L., Fletcher, Jean M., Gilmour, Kimberly C., Sharifi, Reza, Khan, Naeem, Hislop, Andrew D., Cara, Andrea, Salmon, Mike, Gaspar, H. Bobby, Rustin, Malcom H.A., Webster, David, Akbar, Arne N.

“…Patients with X-linked lymphoproliferative syndrome (XLP) experience excessive T cell proliferation after primary Epstein–Barr virus (EBV) infection, due to…”
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IL-7R sub( alpha ) versus CCR7 and CD45 as Markers of Virus-Specific CD8 super(+) T Cell Differentiation: Contrasting Pictures in Blood and Tonsillar Lymphoid Tissue by Sauce, D, Larsen, M, Leese, A M, Millar, D, Khan, N, Hislop, AD, Rickinson, AB

“…In humans, circulating CD8 super(+) memory T cells to a nonpersistent virus (influenza) lie within CCR7 super(+)CD45RA super(-) central memory, whereas memory…”
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B cells immortalized by a mini–Epstein-Barr virus encoding a foreign antigen efficiently reactivate specific cytotoxic T cells by Moosmann, Andreas, Khan, Naeem, Cobbold, Mark, Zentz, Caroline, Delecluse, Henri-Jacques, Hollweck, Gabi, Hislop, Andrew D., Blake, Neil W., Croom-Carter, Debbie, Wollenberg, Barbara, Moss, Paul A.H., Zeidler, Reinhard, Rickinson, Alan B., Hammerschmidt, Wolfgang

“…Lymphoblastoid cell lines (LCLs) are human B cells latently infected and immortalized by Epstein-Barr virus (EBV). Presenting viral antigens, they efficiently…”
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T-Cell Receptor Triggering Differentially Regulates Bim Expression in Human Lymphocytes From Healthy Individuals and Patients With Infectious Mononucleosis by Sandalova, Elena, Hislop, Andrew D., Levitsky, Victor

“…Bim, a proapoptotic member of the Bcl-2 protein family, is a major regulator of central and peripheral T-cell deletion. Regulation of Bim activity by T-cell…”
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Virus-Specific Cytotoxic T Lymphocytes Differentially Express Cell-Surface Leukocyte Immunoglobulin-Like Receptor–1, an Inhibitory Receptor for Class I Major Histocompatibility Complex Molecules by Antrobus, Richard D, Khan, Naeem, Hislop, Andrew D, Montamat-Sicotte, Damien, Garner, Lee I, Rickinson, Alan B, Moss, Paul A. H, Willcox, Benjamin E

“…Leukocyte immunoglobulin-like receptor–1 (LIR-1) is an inhibitory receptor that negatively regulates T cell effector functions after interaction with host…”
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HLA-A11-Restricted Epitope Polymorphism among Epstein-Barr Virus Strains in the Highly HLA-A11-Positive Chinese Population: Incidence and Immunogenicity of Variant Epitope Sequences by Midgley, R S, Bell, A I, Yao, Q Y, Croom-Carter, D, Hislop, A D, Whitney, B M, Chan, A T C, Johnson, P J, Rickinson, A B

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Epitope-specific Evolution of Human CD8 super(+) T Cell Responses from Primary to Persistent Phases of Epstein-Barr Virus Infection by Hislop, AD, Annels, N E, Gudgeon, N H, Leese, A M, Rickinson, AB

“…Primary virus infection often elicits a large CD8 super(+) T cell response which subsequently contracts to a smaller memory T cell pool; the relationship…”
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EBV-Specific CD8 super(+) T Cell Memory: Relationships Between Epitope Specificity, Cell Phenotype, and Immediate Effector Function by Hislop, AD, Gudgeon, N H, Callan, MFC, Fazou, C, Hasegawa, H, Salmon, M, Rickinson, AB

“…EBV infection in humans induces CD8 super(+) T cell memory to viral epitopes derived from both lytic and latent cycle Ags. We have analyzed the relationship…”
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Vaccine-induced cytotoxic T lymphocytes protect against retroviral challenge by Suhrbier, Andreas, Hislop, Andrew D, Good, Michael F, Mateo, Luis, Gardner, Joy, Gatei, Magtouf H, Daniel, Richard C.W, Meyers, Barry V, Lavin, Martin F

“…The development of prophylactic vaccines against retroviral diseases has been impeded by the lack of obvious immune correlates for protection. Cytotoxic…”
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