Search Results - "Hishigaki, H"

Exploratory aspirin resistance trial in healthy Japanese volunteers (J-ART) using platelet aggregation as a measure of thrombogenicity by Fujiwara, T, Ikeda, M, Esumi, K, Fujita, T D, Kono, M, Tokushige, H, Hatoyama, T, Maeda, T, Asai, T, Ogawa, T, Katsumata, T, Sasaki, S, Suzuki, E, Suzuki, M, Hino, F, Fujita, T K, Zaima, H, Shimada, M, Sugawara, T, Tsuzuki, Y, Hashimoto, Y, Hishigaki, H, Horimoto, S, Miyajima, N, Yamamoto, T, Imagawa, K, Sesoko, S, Fujisawa, Y

“…Aspirin prevents the production of thromboxane A2 (TXA2) by irreversibly inhibiting platelet cyclooxygenase, exhibiting antiplatelet actions. This agent has…”
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Comparative FISH mapping of mouse and rat homologues of twenty-five human X-linked genes by Kuroiwa, A, Watanabe, T, Hishigaki, H, Takahashi, E, Namikawa, T, Matsuda, Y

“…We constructed a comparative cytogenetic map of 25 functional genes in mouse and rat X chromosomes by direct R-banding fluorescence in situ hybridization…”
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Automated extraction of information on protein–protein interactions from the biological literature by Ono, Toshihide, Hishigaki, Haretsugu, Tanigami, Akira, Takagi, Toshihisa

“…Motivation: To understand biological process, we must clarify how proteins interact with each other. However, since information about protein–protein…”
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Substitution of Dmo1 with normal alleles results in decreased manifestation of diabetes in OLETF rats by Okuno, S., Kondo, M., Yamasaki, Y., Miyao, H., Ono, T., Iwanaga, T., Omori, K., Okano, M., Suzuki, M., Momota, H., Hishigaki, H., Hayashi, I., Goto, Y., Shinomiya, H., Harada, Y., Hirashima, T., Kanemoto, N., Asai, T., Wakitani, S., Takagi, T., Nakamura, Y., Tanigami, A., Watanabe, T. K.

“…Aim: Dmo1 (Diabetes Mellitus OLETF type I) is a major quantitative trait locus for dyslipidaemia, obesity and diabetes phenotypes in the Otsuka Long Evans…”
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Conservation of the rat X chromosome gene order in rodent species by Kuroiwa, A, Tsuchiya, K, Watanabe, T, Hishigaki, H, Takahashi, E, Namikawa, T, Matsuda, Y

“…We constructed the comparative cytogenetic maps of X chromosomes in three rodent species, Indian spiny mouse (Mus platythrix), Syrian hamster and Chinese…”
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Assessment of prediction accuracy of protein function from protein–protein interaction data by Hishigaki, Haretsugu, Nakai, Kenta, Ono, Toshihide, Tanigami, Akira, Takagi, Toshihisa

“…Functional prediction of open reading frames coded in the genome is one of the most important tasks in yeast genomics. Among a number of large‐scale…”
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hERGAPDbase: a database documenting hERG channel inhibitory potentials and APD-prolongation activities of chemical compounds by Hishigaki, Haretsugu, Kuhara, Satoru

“…Drug-induced QT interval prolongation is one of the most common reasons for the withdrawal of drugs from the market. In the past decade, at least nine drugs,…”
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A radiation hybrid map of the rat genome containing 5,255 markers by Yamasaki, Yuki, Watanabe, Takeshi K, Kanemoto, Naohide, Oga, Keiko, Irie, Yasuo, Browne, Julie, Adachi, Masakazu, Kiguwa, Susanna L, James, Michael R, Critcher, Ricky, Hayashi, Hiromi, Lathrop, G. Mark, Knights, Catherine, Webber, Caleb, Ono, Toshihide, Davis, Marie, Nakamura, Yusuke, Tanigami, Akira, Thangarajah, Thiru, Goodfellow, Peter N, Tsuji, Atsushi, Takahashi, Ei-ichi, Mizoguchi-Miyakita, Ayako, Kiel, Susanne, Hishigaki, Haretsugu, Day, Philip J.R, Miller, Jonathan, Smith, Angela, Tomita, Kazuhiro, Hudson, James R, McCarthy, Linda C, Bihoreau, Marie-Therese, Takagi, Toshihisa, Okuno, Shiro

“…A whole-genome radiation hybrid (RH) panel was used to construct a high-resolution map of the rat genome based on microsatellite and gene markers. These…”
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MUTATED G-PROTEIN-COUPLED RECEPTOR GPR10 IS RESPONSIBLE FOR THE HYPERPHAGIA/DYSLIPIDAEMIA/OBESITY LOCUS OF Dmo1 IN THE OLETF RAT by Watanabe, Takeshi K, Suzuki, Mikio, Yamasaki, Yuki, Okuno, Shiro, Hishigaki, Haretsugu, Ono, Toshihide, Oga, Keiko, Mizoguchi-Miyakita, Ayako, Tsuji, Atsushi, Kanemoto, Naohide, Wakitani, Shigeyuki, Takagi, Toshihisa, Nakamura, Yusuke, Tanigami, Akira

“…SUMMARY 1. We have confirmed the Diabetes Mellitus OLETF type I (Dmo1) effect on hyperphagia, dyslipidaemia and obesity in the Otsuka Long‐Evans Tokushima…”
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Detection of gene expression in synovium of patients with osteoarthritis using a random sequencing method by Okabe, Takahiro, Ohmori, Yoshihiro, Tanigami, Akira, Hishigaki, Haretsugu, Suzuki, Yutaka, Sugano, Sumio, Kawaguchi, Amu, Nakaya, Hiroyuki, Wakitani, Shigeyuki

“…The etiology of osteoarthritis (OA) is multifactorial and current research attributes it to a complex network of biochemical factors. We attempted to identify…”
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Genetic dissection of OLETF, a rat model for non-insulin-dependent diabetes mellitus : Quantitative trait locus analysis of (OLETF x BN) x OLETF by WATANABE, T. K, OKUNO, S, IRIE, Y, NAKAMURA, Y, TANIGAMI, A, OGA, K, MIZOGUCHI-MIYAKITA, A, TSUJI, A, YAMASAKI, Y, HISHIGAKI, H, KANEMOTO, N, TAKAGI, T, TAKAHASHI, E.-I

“…To identify genetic determinants relevant to non-insulin-dependent diabetes mellitus (NIDDM), we performed a genome-wide analysis for quantitative trait loci…”
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Genetic dissection of "OLETF", a rat model for non-insulin-dependent diabetes mellitus by Kanemoto, N, Hishigaki, H, Miyakita, A, Oga, K, Okuno, S, Tsuji, A, Takagi, T, Takahashi, E, Nakamura, Y, Watanabe, T K

“…To elucidate the genetic factors underlying non-insulin-dependent diabetes mellitus (NIDDM), we performed genome-wide quantitative trait locus (QTL) analysis,…”
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Mining the quantitative trait loci associated with oral glucose tolerance in the OLETF rat by Nakaya, A, Hishigaki, H, Morishita, S

“…Although the synergetic effects of multiple marker loci regarding quantitative traits such as blood glucose level have attracted interest, previous conclusions…”
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Cloning and Characterization of a Novel Member of the Human Mad Gene Family (MADH6) by Watanabe, Takeshi K., Suzuki, Mikio, Omori, Yoshihiro, Hishigaki, Haretsugu, Horie, Masato, Kanemoto, Naohide, Fujiwara, Tsutomu, Nakamura, Yusuke, Takahashi, Ei-ichi

“…MAD (mothers against decapentaplegic)-related proteins (MADRs) are intracellular components that play critical roles in signal-transduction pathways involving…”
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A < 1.7 cM interval is responsible for Dmo1 obesity phenotypes in OLETF rats by Watanabe, Takeshi K, Okuno, Shiro, Yamasaki, Yuki, Ono, Toshihide, Oga, Keiko, Mizoguchi-Miyakita, Ayako, Miyao, Hideo, Suzuki, Mikio, Momota, Hiroshi, Goto, Yoshihiro, Shinomiya, Hiroichi, Hishigaki, Haretsugu, Hayashi, Isamu, Asai, Toshihiro, Wakitani, Shigeyuki, Takagi, Toshihisa, Nakamura, Yusuke, Tanigami, Akira

“…Summary 1. Dmo1 (Diabetes Mellitus OLETF type I) is a major quantitative trait locus for dyslipidaemia, obesity and diabetes phenotypes of male Otsuka Long…”
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A whole-genome radiation hybrid panel and framework map of the rat genome by McCarthy, L C, Bihoreau, M T, Kiguwa, S L, Browne, J, Watanabe, T K, Hishigaki, H, Tsuji, A, Kiel, S, Webber, C, Davis, M E, Knights, C, Smith, A, Critcher, R, Huxtall, P, Hudson, Jr, J R, Ono, T, Hayashi, H, Takagi, T, Nakamura, Y, Tanigami, A, Goodfellow, P N, Lathrop, G M, James, M R

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Characterization of newly developed SSLP markers for the rat by Watanabe, T K, Ono, T, Okuno, S, Mizoguchi-Miyakita, A, Yamasaki, Y, Kanemoto, N, Hishigaki, H, Oga, K, Takahashi, E, Irie, Y, Bihoreau, M T, James, M R, Lathrop, G M, Takagi, T, Nakamura, Y, Tanigami, A

“…We have isolated more than 12,000 clones containing microsatellite sequences, mainly consisting of (CA)n dinucleotide repeats, using genomic DNA from the BN…”
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Quantitative trait loci for lipid metabolism in the study of OLETF x (OLETF x Fischer 344) backcross rats by Yamasaki, Y, Watanabe, T K, Okuno, S, Ono, T, Oga, K, Mizoguchi-Miyakita, A, Goto, Y, Shinomiya, H, Momota, H, Miyao, H, Hayashi, I, Asai, T, Suzuki, M, Harada, Y, Hishigaki, H, Wakitani, S, Takagi, T, Nakamura, Y, Tanigami, A

“…1. The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is a model of type II diabetes with accompanying dyslipidaemia and obesity. 2. To define chromosomal…”
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Single-Allele Correction Of The Dmo1 Locus In Congenic Animals Substantially Attenuates Obesity, Dyslipidaemia And Diabetes Phenotypes Of The Oletf Rat by Watanabe, Takeshi K, Okuno, Shiro, Ono, Toshihide, Yamasaki, Yuki, Oga, Keiko, Mizoguchi-Miyakita, Ayako, Miyao, Hideo, Suzuki, Mikio, Momota, Hiroshi, Goto, Yoshihiro, Shinomiya, Hiroichi, Hishigaki, Haretsugu, Hayashi, Isamu, Asai, Toshihiro, Wakitani, Shigeyuki, Takagi, Toshihisa, Nakamura, Yusuke, Tanigami, Akira

“…SUMMARY 1. Whole‐genome scans have identified Dmo1 as a major quantitative trait locus for dyslipidaemia and obesity in the Otsuka Long Evans Tokushima Fatty…”
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Genetic analysis of pancreatic duct hyperplasia in Otsuka Long-Evans Tokushima Fatty rats: Possible association with a region on rat chromosome 14 that includes the disrupted cholecystokinin-A receptor gene by Kanemoto, Naohide, Kondo, Mari, Iwanaga, Tomoyuki, Hishigaki, Haretsugu, Ono, Toshihide, Mizoguchi-Miyakita, Ayako, Oga, Keiko, Tsuji, Atsushi, Okuno, Shiro, Watanabe, Takeshi K., Nose, Masato, Tanigami, Akira

“…An Otsuka Long–Evans Tokushima Fatty (OLETF) strain of rat spontaneously developed hyperglycemia, hyperinsulinemia, insulin resistance and mild obesity, which…”
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