Search Results - "Hiser, Carrie"

The K-path entrance in cytochrome c oxidase is defined by mutation of E101 and controlled by an adjacent ligand binding domain by Hiser, Carrie, Liu, Jian, Ferguson-Miller, Shelagh

“…Three mutant forms of Rhodobacter sphaeroides cytochrome c oxidase (RsCcO) were created to test for multiple K-path entry sites (E101W), the existence of an…”
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Role of conformational change and K-path ligands in controlling cytochrome c oxidase activity by Liu, Jian, Hiser, Carrie, Ferguson-Miller, Shelagh

“…Given the central role of cytochrome oxidase (C O) in health and disease, it is an increasingly important question as to how the activity and efficiency of…”
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Gating and regulation of the cytochrome c oxidase proton pump by Ferguson-Miller, Shelagh, Hiser, Carrie, Liu, Jian

“…As a consumer of 95% of the oxygen we breathe, cytochrome c oxidase plays a major role in the energy balance of the cell. Regulation of its oxygen reduction…”
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Identification of Conserved Lipid/detergent-Binding Sites in a High-Resolution Structure of the Membrane Protein Cytochrome c Oxidase by Qin, Ling, Hiser, Carrie, Mulichak, Anne, Garavito, R. Michael, Ferguson-Miller, Shelagh

“…Well ordered reproducible crystals of cytochrome c oxidase (CcO) from Rhodobactersphaeroides yield a previously unreported structure at 2.0 Å resolution that…”
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Identification of a Key Cholesterol Binding Enhancement Motif in Translocator Protein 18 kDa by Li, Fei, Liu, Jian, Valls, Lance, Hiser, Carrie, Ferguson-Miller, Shelagh

“…Translocator protein 18 kDa (TSPO) in the mitochondrial outer membrane has been implicated in cholesterol transport regulating steroidogenesis. A human single…”
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A Conserved Amphipathic Ligand Binding Region Influences K‑Path-Dependent Activity of Cytochrome c Oxidase by Hiser, Carrie, Buhrow, Leann, Liu, Jian, Kuhn, Leslie, Ferguson-Miller, Shelagh

“…A conserved, crystallographically defined bile acid binding site was originally identified in the membrane domain of mammalian and bacterial cytochrome c…”
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Cardiolipin Deficiency in Rhodobacter sphaeroides Alters the Lipid Profile of Membranes and of Crystallized Cytochrome Oxidase, but Structure and Function Are Maintained by Zhang, Xi, Tamot, Banita, Hiser, Carrie, Reid, Gavin E, Benning, Christoph, Ferguson-Miller, Shelagh

“…Many recent studies highlight the importance of lipids in membrane proteins, including in the formation of well-ordered crystals. To examine the effect of…”
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Crystallographic Location and Mutational Analysis of Zn and Cd Inhibitory Sites and Role of Lipidic Carboxylates in Rescuing Proton Path Mutants in Cytochrome c Oxidase by Qin, Ling, Mills, Denise A, Hiser, Carrie, Murphree, Anna, Garavito, R. Michael, Ferguson-Miller, Shelagh, Hosler, Jonathan

“…Cytochrome c oxidase (CcO) transfers protons from the inner surface of the enzyme to the buried O2 reduction site through two different pathways, termed K and…”
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Role of the Conserved Arginine Pair in Proton and Electron Transfer in Cytochrome c Oxidase by Qian, Jie, Mills, Denise A, Geren, Lois, Wang, Keifei, Hoganson, Curt W, Schmidt, Bryan, Hiser, Carrie, Babcock, Gerald T, Durham, Bill, Millett, Francis, Ferguson-Miller, Shelagh

“…A hydrogen-bonded network is observed above the hemes in all of the high-resolution crystal structures of cytochrome oxidases. It includes water and a pair of…”
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The K-path entrance in cytochrome c oxidase is defined by mutation of E101 and controlled by an adjacent ligand binding domain by Hiser, Carrie, Liu, Jian, Ferguson-Miller, Shelagh

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TSPO protein binding partners in bacteria, animals, and plants by Hiser, Carrie, Montgomery, Beronda L., Ferguson-Miller, Shelagh

“…The ancient membrane protein TSPO is phylogenetically widespread from archaea and bacteria to insects, vertebrates, plants, and fungi. TSPO’s primary amino…”
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New TSPO Crystal Structures of Mutant and Heme-Bound Forms with Altered Flexibility, Ligand Binding, and Porphyrin Degradation Activity by Liu, Jian, Hiser, Carrie, Li, Fei, Hall, Robert, Garavito, R. Michael, Ferguson-Miller, Shelagh

“…The ancient protein TSPO (translocator protein 18kD) is found in all kingdoms and was originally identified as a binding site of benzodiazepine drugs. Its…”
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Correction to “New TSPO Crystal Structures of Mutant and Heme-Bound Forms with Altered Flexibility, Ligand Binding, and Porphyrin Degradation Activity” by Liu, Jian, Hiser, Carrie, Li, Fei, Hall, Robert, Garavito, R. Michael, Ferguson-Miller, Shelagh

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Membrane Potential-controlled Inhibition of Cytochromec Oxidase by Zinc by Mills, Denise A., Schmidt, Bryan, Hiser, Carrie, Westley, Erica, Ferguson-Miller, Shelagh

“…Like many voltage-sensitive ion pumps, cytochromec oxidase is inhibited by zinc. Binding of zinc to the outside surface of Rhodobacter sphaeroides cytochromec…”
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Genetic modification of respiratory capacity in potato by Carrie Hiser, Kapranov, Philipp, McIntosh, Lee

“…Mitochondrial respiration was altered in transgenic potato (Solanum tuberosum) lines by overexpression of the alternative oxidase Aox1 gene. Overexpressing…”
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Tryptophan rich sensory protein, TSPO: Functional insights from high resolution structures by Ferguson-Miller, Shelagh, Liu, Jian, Li, Fei, Hiser, Carrie, Lapres, John, Michael Garavito, R.

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Redox-Dependent Conformational Changes in Cytochrome c Oxidase Suggest a Gating Mechanism for Proton Uptake by Qin, Ling, Liu, Jian, Mills, Denise A, Proshlyakov, Denis A, Hiser, Carrie, Ferguson-Miller, Shelagh

“…A role for conformational change in the coupling mechanism of cytochrome c oxidase is the subject of controversy. Relatively small conformational changes have…”
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Alternative oxidase of potato is an integral membrane protein synthesized de novo during aging of tuber slices by Hiser, C. (Michigan State University, East Lansing, MI), McIntosh, L

“…The rise in alternative respiratory capacity upon aging of potato (Solanum tuberosum) tuber slices is correlated with changes in mitochondrial membrane protein…”
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Translocator protein 18 kDa (TSPO): Structural insights and functional questions by Ferguson-Miller, Shelagh, Li, Fei, Liu, Jian, Hiser, Carrie, Garavito, Michael R.

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Expression, Purification and Characterization of Bacterial and Human Translocator Protein 18 kDa (TSPO) by Li, Fei, Hiser, Carrie, Ferguson-Miller, Shelagh

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