Search Results - "Hirvonen, Jouni"

Properties and chemical modifications of lignin: Towards lignin-based nanomaterials for biomedical applications by Figueiredo, Patrícia, Lintinen, Kalle, Hirvonen, Jouni T., Kostiainen, Mauri A., Santos, Hélder A.

“…Biorenewable polymers have emerged as an attractive alternative to conventional metallic and organic materials for a variety of different applications. This is…”
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Pharmaceutical nanocrystals by nanomilling: critical process parameters, particle fracturing and stabilization methods by Peltonen, Leena, Hirvonen, Jouni

“…Objectives  Wet milling is a common technique to produce drug nanocrystals. Stability of the nanocrystals is a critical question, and different kinds of…”
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Current developments and applications of microfluidic technology toward clinical translation of nanomedicines by Liu, Dongfei, Zhang, Hongbo, Fontana, Flavia, Hirvonen, Jouni T., Santos, Hélder A.

“…Nanoparticulate drug delivery systems hold great potential for the therapy of many diseases, especially cancer. However, the translation of nanoparticulate…”
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Tailoring Porous Silicon for Biomedical Applications: From Drug Delivery to Cancer Immunotherapy by Li, Wei, Liu, Zehua, Fontana, Flavia, Ding, Yaping, Liu, Dongfei, Hirvonen, Jouni T., Santos, Hélder A.

“…In the past two decades, porous silicon (PSi) has attracted increasing attention for its potential biomedical applications. With its controllable geometry,…”
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Microfluidics for Production of Particles: Mechanism, Methodology, and Applications by Liu, Zehua, Fontana, Flavia, Python, Andre, Hirvonen, Jouni T., Santos, Hélder A.

“…In the past two decades, microfluidics‐based particle production is widely applied for multiple biological usages. Compared to conventional bulk methods,…”
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Production of pure drug nanocrystals and nano co-crystals by confinement methods by Fontana, Flavia, Figueiredo, Patrícia, Zhang, Pei, Hirvonen, Jouni T., Liu, Dongfei, Santos, Hélder A.

“…The use of drug nanocrystals in the drug formulation is increasing due to the large number of poorly water-soluble drug compounds synthetized and due to the…”
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The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties by Shahbazi, Mohammad-Ali, Faghfouri, Leila, Ferreira, Mónica P A, Figueiredo, Patrícia, Maleki, Hajar, Sefat, Farshid, Hirvonen, Jouni, Santos, Hélder A

“…Studies of nanosized forms of bismuth (Bi)-containing materials have recently expanded from optical, chemical, electronic, and engineering fields towards…”
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Stabilizing Agents for Drug Nanocrystals: Effect on Bioavailability by Tuomela, Annika, Hirvonen, Jouni, Peltonen, Leena

“…Drug nanocrystals are a versatile option for drug delivery purposes, and while the number of poorly soluble drug materials is all the time increasing, more…”
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High drug-loaded microspheres enabled by controlled in-droplet precipitation promote functional recovery after spinal cord injury by Li, Wei, Chen, Jian, Zhao, Shujie, Huang, Tianhe, Ying, Huiyan, Trujillo, Claudia, Molinaro, Giuseppina, Zhou, Zheng, Jiang, Tao, Liu, Wei, Li, Linwei, Bai, Yuancheng, Quan, Peng, Ding, Yaping, Hirvonen, Jouni, Yin, Guoyong, Santos, Hélder A., Fan, Jin, Liu, Dongfei

“…Drug delivery systems with high content of drug can minimize excipients administration, reduce side effects, improve therapeutic efficacy and/or promote…”
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Multistaged Nanovaccines Based on Porous Silicon@Acetalated Dextran@Cancer Cell Membrane for Cancer Immunotherapy by Fontana, Flavia, Shahbazi, Mohammad‐Ali, Liu, Dongfei, Zhang, Hongbo, Mäkilä, Ermei, Salonen, Jarno, Hirvonen, Jouni T., Santos, Hélder A.

“…Immunoadjuvant porous silicon (PSi)‐based nanovaccines are prepared by nanoprecipitation in a glass capillary microfluidics device. Vesicles, derived from…”
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Artificially cloaked viral nanovaccine for cancer immunotherapy by Fusciello, Manlio, Fontana, Flavia, Tähtinen, Siri, Capasso, Cristian, Feola, Sara, Martins, Beatriz, Chiaro, Jacopo, Peltonen, Karita, Ylösmäki, Leena, Ylösmäki, Erkko, Hamdan, Firas, Kari, Otto K., Ndika, Joseph, Alenius, Harri, Urtti, Arto, Hirvonen, Jouni T., Santos, Hélder A., Cerullo, Vincenzo

“…Virus-based cancer vaccines are nowadays considered an interesting approach in the field of cancer immunotherapy, despite the observation that the majority of…”
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Non-viral nanoparticles for RNA interference: Principles of design and practical guidelines by Liu, Zehua, Wang, Shiqi, Tapeinos, Christos, Torrieri, Giulia, Känkänen, Voitto, El-Sayed, Nesma, Python, Andre, Hirvonen, Jouni T., Santos, Hélder A.

“…[Display omitted] Ribonucleic acid interference (RNAi) is an innovative treatment strategy for a myriad of indications. Non-viral synthetic nanoparticles (NPs)…”
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Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles, and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics by Liu, Zehua, Li, Yunzhan, Li, Wei, Xiao, Chen, Liu, Dongfei, Dong, Chao, Zhang, Ming, Mäkilä, Ermei, Kemell, Marianna, Salonen, Jarno, Hirvonen, Jouni T., Zhang, Hongbo, Zhou, Dawang, Deng, Xianming, Santos, Hélder A.

“…Herein, a novel nanohybrid based on porous silicon, gold nanoparticles (Au NPs), and acetalated dextran (DPSi/DAu@AcDEX) is reported to encapsulate and deliver…”
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The impact of nanoparticles on the mucosal translocation and transport of GLP-1 across the intestinal epithelium by Araújo, Francisca, Shrestha, Neha, Shahbazi, Mohammed-Ali, Fonte, Pedro, Mäkilä, Ermei M, Salonen, Jarno J, Hirvonen, Jouni T, Granja, Pedro L, Santos, Hélder A, Sarmento, Bruno

“…Abstract Glucagon like peptide-1 (GLP-1) is an incretin hormone that is in the pipeline for type 2 diabetes mellitus (T2DM) therapy. However, oral…”
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Nanosuspensions of poorly soluble drugs: Preparation and development by wet milling by Liu, Peng, Rong, Xinyu, Laru, Johanna, van Veen, Bert, Kiesvaara, Juha, Hirvonen, Jouni, Laaksonen, Timo, Peltonen, Leena

“…Nanosizing techniques are important tools for improving the bioavailability of water insoluble drugs. Here, a rapid wet milling method was employed to prepare…”
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Bioengineered Porous Silicon Nanoparticles@Macrophages Cell Membrane as Composite Platforms for Rheumatoid Arthritis by Fontana, Flavia, Albertini, Silvia, Correia, Alexandra, Kemell, Marianna, Lindgren, Rici, Mäkilä, Ermei, Salonen, Jarno, Hirvonen, Jouni T., Ferrari, Franca, Santos, Hélder A.

“…Biohybrid nanosystems are at the center of personalized medicine, affording prolonged circulation time and targeting to the disease site, and serving as…”
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Conductive vancomycin-loaded mesoporous silica polypyrrole-based scaffolds for bone regeneration by Zanjanizadeh Ezazi, Nazanin, Shahbazi, Mohammad-Ali, Shatalin, Yuri V., Nadal, Eloy, Mäkilä, Ermei, Salonen, Jarno, Kemell, Marianna, Correia, Alexandra, Hirvonen, Jouni, Santos, Hélder A.

“…[Display omitted] Bone tissue engineering is considered an alternative approach for conventional strategies available to treat bone defects. In this study, we…”
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Fabrication of a Multifunctional Nano-in-micro Drug Delivery Platform by Microfluidic Templated Encapsulation of Porous Silicon in Polymer Matrix by Zhang, Hongbo, Liu, Dongfei, Shahbazi, Mohammad-Ali, Mäkilä, Ermei, Herranz-Blanco, Bárbara, Salonen, Jarno, Hirvonen, Jouni, Santos, Hélder A.

“…A multifunctional nano‐in‐micro drug delivery platform is developed by conjugating the porous silicon nanoparticles with mucoadhesive polymers and subsequent…”
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The mechanisms of surface chemistry effects of mesoporous silicon nanoparticles on immunotoxicity and biocompatibility by Shahbazi, Mohammad-Ali, Hamidi, Mehrdad, Mäkilä, Ermei M, Zhang, Hongbo, Almeida, Patrick V, Kaasalainen, Martti, Salonen, Jarno J, Hirvonen, Jouni T, Santos, Hélder A

“…Abstract Despite steadily increasing insights on the biocompatibility of PSi nanoparticles (NPs), an extensive biosafety study on the immune and red blood…”
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Drug release from nanoparticles embedded in four different nanofibrillar cellulose aerogels by Valo, Hanna, Arola, Suvi, Laaksonen, Päivi, Torkkeli, Mika, Peltonen, Leena, Linder, Markus B., Serimaa, Ritva, Kuga, Shigenori, Hirvonen, Jouni, Laaksonen, Timo

“…[Display omitted] Highly porous nanocellulose aerogels prepared by freeze-drying from various nanofibrillar cellulose (NFC) hydrogels are introduced as…”
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