Search Results - "Hirst, W. D."

Differential involvement of 5-HT1B/1D and 5-HT6 receptors in cognitive and non-cognitive symptoms in Alzheimer's disease by GARCIA-ALLOZA, M, HIRST, W. D, CHEN, C. P. L-H, LASHERAS, B, FRANCIS, P. T, RAMIREZ, M. J

“…Growing evidence suggests that a compromised serotonergic system plays an important role in the pathophysiology of Alzheimer's disease (AD). We assessed the…”
Get full text

GBA mutations in Parkinson disease: earlier death but similar neuropathological features by Adler, C. H., Beach, T. G., Shill, H. A., Caviness, J. N., Driver‐Dunckley, E., Sabbagh, M. N., Patel, A., Sue, L. I., Serrano, G., Jacobson, S. A., Davis, K., Belden, C. M., Dugger, B. N., Paciga, S. A., Winslow, A. R., Hirst, W. D., Hentz, J. G.

“…Background and purpose Mutations in the glucocerebrosidase (GBA) gene are known to be a risk factor for Parkinson's disease (PD). Data on clinicopathological…”
Get full text

Serotonin transporters in adult rat brain astrocytes revealed by [3H]5-HT uptake into glial plasmalemmal vesicles by Hirst, W.D, Price, G.W, Rattray, M, Wilkin, G.P

“…Cultured astrocytes derived from neonatal rat brain exhibited high affinity, Na+-dependent, paroxetine and fluoxetine sensitive [3H] 5-HT uptake. Reverse…”
Get full text

The human GABAB1b and GABAB2 heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen by Wood, M D, Murkitt, K L, Rice, S Q, Testa, T, Punia, P K, Stammers, M, Jenkins, O, Elshourbagy, N A, Shabon, U, Taylor, S J, Gager, T L, Minton, J, Hirst, W D, Price, G W, Pangalos, M

“…The aim of this study was to characterize the pharmacological profile of the GABAB1/GABAB2 heterodimeric receptor expressed in Chinese hamster ovary (CHO)…”
Get full text

Identification of 5‐hydroxytryptamine receptors positively coupled to adenylyl cyclase in rat cultured astrocytes by Hirst, Warren D., Price, Gary W., Rattray, Marcus, Wilkin, Graham P.

“…1 5‐Hydroxytryptamine (5‐HT) elicited a dose‐dependent stimulation of intracellular adenosine 3′: 5′‐cyclic monophosphate (cyclic AMP) accumulation in cultured…”
Get full text

Cortical spreading depression produces increased cGMP levels in cortex and brain stem that is inhibited by tonabersat (SB-220453) but not sumatriptan by Read, Simon J., Hirst, Warren D., Upton, Neil, Parsons, Andrew A.

“…Migraine headache is proposed to be mediated by nitric oxide (NO). Suitable mechanisms for eliciting increases in brain NO concentration in migraineurs have…”
Get full text

De novo expression of lipocortin-1 in reactive microglia and astrocytes in kainic acid lesioned rat cerebellum by Young, Karen A., Hirst, Warren D., Solito, Egle, Wilkin, Graham P.

“…An understanding of the role of reactive glia in the neurodegenerative/regenerative process requires a knowledge of the molecules synthesised by these cells…”
Get full text

GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer by Robbins, M J, Calver, A R, Filippov, A K, Hirst, W D, Russell, R B, Wood, M D, Nasir, S, Couve, A, Brown, D A, Moss, S J, Pangalos, M N

“…GABA(B) receptors are unique among G-protein-coupled receptors (GPCRs) in their requirement for heterodimerization between two homologous subunits, GABA(B1)…”
Get full text

Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice by Prosser, H M, Gill, C H, Hirst, W D, Grau, E, Robbins, M, Calver, A, Soffin, E M, Farmer, C E, Lanneau, C, Gray, J, Schenck, E, Warmerdam, B S, Clapham, C, Reavill, C, Rogers, D C, Stean, T, Upton, N, Humphreys, K, Randall, A, Geppert, M, Davies, C H, Pangalos, M N

“…The recent cloning of two GABA(B) receptor subunits, GABA(B1) and GABA(B2), has raised the possibility that differences in GABA(B) receptor subunit composition…”
Get full text

Cyclic AMP-dependent protein kinase phosphorylation facilitates GABA(B) receptor-effector coupling by Couve, A, Thomas, P, Calver, A R, Hirst, W D, Pangalos, M N, Walsh, F S, Smart, T G, Moss, S J

“…GABA (gamma-aminobutyric acid)(B) receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system…”
Get full text

The C-terminal domains of the GABA(b) receptor subunits mediate intracellular trafficking but are not required for receptor signaling by Calver, A R, Robbins, M J, Cosio, C, Rice, S Q, Babbs, A J, Hirst, W D, Boyfield, I, Wood, M D, Russell, R B, Price, G W, Couve, A, Moss, S J, Pangalos, M N

“…GABA(B) receptors are G-protein-coupled receptors that mediate slow synaptic inhibition in the brain and spinal cord. These receptors are heterodimers…”
Get full text

Molecular and pharmacological characterization of a functional tachykinin NK3 receptor cloned from the rabbit iris sphincter muscle by Medhurst, Andrew D, Hirst, Warren D, Jerman, Jeffery C, Meakin, Jacqueline, Roberts, Jennifer C, Testa, Tania, Smart, Darren

“…A functional tachykinin NK3 receptor was cloned from the rabbit iris sphincter muscle and its distribution investigated in ocular tissues. Standard polymerase…”
Get full text

Characterization of [125I]‐SB‐258585 binding to human recombinant and native 5‐HT6 receptors in rat, pig and human brain tissue by Hirst, Warren D, Minton, Jayne A L, Bromidge, Steven M, Moss, Stephen F, Latter, Alison J, Riley, Graham, Routledge, Carol, Middlemiss, Derek N, Price, Gary W

“…SB‐258585 (4‐Iodo‐N‐[4‐methoxy‐3‐(4‐methyl‐piperazin‐1‐yl)‐phenyl]‐benzenesulphonamide) is a high affinity ligand at 5‐HT6 receptors. It displays over 100 fold…”
Get full text

Vesicle exocytosis stimulated by α-latrotoxin is mediated by latrophilin and requires both external and stored Ca2 by Davletov, Bazbek A., Meunier, Frédéric A., Ashton, Anthony C., Matsushita, Hiroaki, Hirst, Warren D., Lelianova, Vera G., Wilkin, Graham P., Dolly, J.Oliver, Ushkaryov, Yuri A.

“…α‐Latrotoxin (LTX) stimulates massive neurotransmitter release by two mechanisms: Ca2+‐dependent and ‐independent. Our studies on norepinephrine secretion from…”
Get full text

Expression of COX-2 by Normal and Reactive Astrocytes in the Adult Rat Central Nervous System by Hirst, Warren D., Young, Karen A., Newton, Robert, Allport, Victoria C., Marriott, Derek R., Wilkin, Graham P.

“…We have used a previously characterized antiserum against cycloxygenase-2 (COX-2) together with cold methanol fixation to immunohistochemically locate the…”
Get full text

Characterization of the binding of [125I]‐human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor by Langmead, Christopher J, Szekeres, Philip G, Chambers, Jonathan K, Ratcliffe, Steven J, Jones, Declan N C, Hirst, Warren D, Price, Gary W, Herdon, Hugh J

“…GPR10 is a novel G‐protein coupled receptor that is the human orthologue of rat Unknown Hypothalamic Receptor‐1 (UHR‐1). Human prolactin‐releasing peptide…”
Get full text

Perspective on the current state of the LRRK2 field by Taymans, Jean-Marc, Fell, Matt, Greenamyre, Tim, Hirst, Warren D., Mamais, Adamantios, Padmanabhan, Shalini, Peter, Inga, Rideout, Hardy, Thaler, Avner

“…Almost 2 decades after linking LRRK2 to Parkinson’s disease, a vibrant research field has developed around the study of this gene and its protein product…”
Get full text

The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen by Wood, M D, Murkitt, K L, Rice, S Q, Testa, T, Punia, P K, Stammers, M, Jenkins, O, Elshourbagy, N A, Shabon, U, Taylor, S J, Gager, T L, Minton, J, Hirst, W D, Price, G W, Pangalos, M

“…1. The aim of this study was to characterize the pharmacological profile of the GABA(B1)/GABA(B2) heterodimeric receptor expressed in Chinese hamster ovary…”
Get full text

The LXR agonist TO901317 selectively lowers hippocampal A beta 42 and improves memory in the Tg2576 mouse model of Alzheimer's disease by Riddell, DR, Zhou, H, Comery, T A, Kouranova, E, Lo, C F, Warwick, H K, Ring, R H, Kirksey, Y, Aschmies, S, Xu, J, Kubek, K, Hirst, W D, Gonzales, C, Chen, Y, Murphy, E, Leonard, S, Vasylyev, D, Oganesian, A, Martone, R L, Pangalos, M N, Reinhart, PH, Jacobsen, J S

“…Recent studies show that intracellular cholesterol levels can modulate the processing of amyloid precursor protein to A beta peptide. Moreover,…”
Get full text

Cultured astrocytes express messenger RNA for multiple serotonin receptor subtypes, without functional coupling of 5-HT1 receptor subtypes to adenylyl cyclase by Hirst, W D, Cheung, N Y, Rattray, M, Price, G W, Wilkin, G P

“…The literature describing the expression of 5-HT receptor subtypes by astrocytes is controversial and incomplete. It is clear that primary cultures of…”
Get full text