Search Results - "Hirst, T C"

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  1. 1

    Systematic review and meta-analysis of temozolomide in animal models of glioma: was clinical efficacy predicted? by Hirst, T C, Vesterinen, H M, Sena, E S, Egan, K J, Macleod, M R, Whittle, I R

    Published in British journal of cancer (15-01-2013)
    “…Background: Malignant glioma is an aggressive tumour commonly associated with a dismal outcome despite optimal surgical and radio-chemotherapy. Since 2005…”
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    Journal Article
  2. 2

    Meta-analysis of data from animal studies: A practical guide by Vesterinen, H.M., Sena, E.S., Egan, K.J., Hirst, T.C., Churolov, L., Currie, G.L., Antonic, A., Howells, D.W., Macleod, M.R.

    Published in Journal of neuroscience methods (15-01-2014)
    “…•Meta-analysis is an invaluable tool in the life sciences.•Methods for the application to clinical data are well documented.•Consideration is required when…”
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    Journal Article
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    A systematic review and meta‐analysis of gene therapy in animal models of cerebral glioma: why did promise not translate to human therapy? by Hirst, T. C., Vesterinen, H. M., Conlin, S., Egan, K. J., Antonic, A., Lawson McLean, A., Macleod, M. R., Grant, R., Brennan, P. M., Sena, E. S., Whittle, I. R.

    Published in Evidence-based preclinical medicine (01-12-2014)
    “…Background The development of therapeutics is often characterized by promising animal research that fails to translate into clinical efficacy; this holds for…”
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    Journal Article
  5. 5

    P08.23 A systematic review and meta-analysis of topoisomerase inhibition in pre-clinical glioma models by Jue, T. J., Hirst, T. C., Sena, E. S., Macleod, M. R., McDonald, K. L.

    Published in Neuro-oncology (Charlottesville, Va.) (01-05-2017)
    “…Background : Glioblastoma is the most common malignant primary brain tumor in adults. Pre-clinical animal studies make an important contribution to the…”
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    Journal Article
  6. 6

    P60 WHY ANIMAL MODELS OF GENE THERAPY HAVE LET GLIOMA PATIENTS DOWN by Hirst, T. C., Vesterinen, H. M., Conlin, S., Egan, K. J., Antonic, A., McLean, A. L., Macleod, M. R., Whittle, I. R., Grant, R., Brennan, P. M., Sena, E. S.

    Published in Neuro-oncology (Charlottesville, Va.) (01-10-2014)
    “…INTRODUCTION: The development of new therapeutics is often characterised by promising animal research that fails to translate into clinical efficacy; this…”
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    Journal Article
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