Search Results - "Hirst, Simon C."

Fenretinide Derivatives Act as Disrupters of Interactions of Serum Retinol Binding Protein (sRBP) with Transthyretin and the sRBP Receptor by Campos-Sandoval, José Angel, Redondo, Clara, Kinsella, Gemma K, Pal, Akos, Jones, Geraint, Eyre, Gwen S, Hirst, Simon C, Findlay, John B. C

“…Serum retinol binding protein (sRBP) is released from the liver as a complex with transthyretin (TTR), a process under the control of dietary retinol. Elevated…”
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Conformational selectivity in molecular recognition: the influence of artificial receptors on the cis-trans isomerization of acylprolines by Vicent, Cristina, Hirst, Simon C, Garcia-Tellado, Fernando, Hamilton, Andrew D

“…The cis-trans isomerization of acylprolyl groups is a kinetically significant step in protein folding and, as such, has been the subject of intense scrutiny…”
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[3 + 2] cycloaddition reactions of 4-alkyl-3-hydroxy-2H-pyrazolo[4,3-c]isoquinolinium inner salts by Phillips, Eifion D, Hirst, Simon C, Perry, Matthew W D, Withnall, Jane

“…Heating dipolarophiles with 4-alkyl-3-hydroxy-2H-pyrazolo[4,3-c]isoquinolinium hydroxide inner salts results in [3 + 2] cycloaddition across positions 3a and 5…”
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Annulation of imidazolines with bis-electrophiles: Synthesis of imidazo[1,2- a]pyridines by Jones, Raymond C.F., Patel, Pravin, Hirst, Simon C, Smallridge, Mark J

“…1-Benzyl-2-(ethoxycarbonylmethylene)-2,3,4,5-tetrahydroimidazole undergoes annulation with a variety of 1,3-bis-electrophiles (α,β-unsaturated acid…”
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[3 + 2] Cycloaddition Reactions of 4-Alkyl-3-hydroxy-2H-pyrazolo[4,3-c]iso- quinolinium Inner Salts by Phillips, Eifion D, Hirst, Simon C, Perry, Matthew W. D, Withnall, Jane

“…Heating dipolarophiles with 4-alkyl-3-hydroxy-2H-pyrazolo[4,3-c]isoquinolinium hydroxide inner salts results in [3 + 2] cycloaddition across positions 3a and 5…”
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A new chiral heterocyclic 1,1-enediamine as a precursor to piperidines by Jones, Raymond C. F., Hirst, Simon C.

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Complexation control of pericyclic reactions: supramolecular effects on the intramolecular Diels-Alder reaction by Hirst, Simon C, Hamilton, Andrew D

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Complexation control of pericyclic reactions: supramolecular effects on the intramolecular Diels-Alder reaction [Erratum to document cited in CA114(3):23229t] by Hirst, Simon C, Hamilton, Andrew D

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New functionalised silicas for highly selective cation exchange SPE purification in medicinal chemistry by Brown, Jane, Chighine, Alessandra, Colucci, Marie A., Galaffu, Nicola, Hirst, Simon C., Seymour, Helen M., Shiers, Jason J., Wilkes, Robin D., Williams, Jonathan G., Wilson, John R.H.

“…Functionalised silicas 2 and 3 are effective for cation exchange purifications of basic molecules containing acid-sensitive functionalities, selective…”
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[3 + 2] Cycloaddition Reactions of 4-Alkyl-3-hydroxy-2 H -pyrazolo[4,3- c ]iso- quinolinium Inner Salts by Phillips, Eifion D., Hirst, Simon C., Perry, Matthew W. D., Withnall, Jane

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Alkylation of an imidazolidine enaminoester: A new sequence for the Cα-alkylation of 4,5-dihydroimidazoles by Jones, Raymond C.F, Patel, Pravin, Hirst, Simon C, Turner, Ian

“…1-Benzyl-2-(ethoxycarbonylmethylene)-2,3,4,5-tetrahydroimidazole undergoes preferred C-alkylation with halogenoalkanes, dihalogenoalkanes and epoxides;…”
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