Search Results - "Hirst, Jonathan J"

Regulation of inflammatory genes in decidual cells: Involvement of the bromodomain and extra-terminal family proteins by Ajgaonkar, Sandeep, Hirst, Jonathan J, Norris, Mary, Zakar, Tamas

“…The decidua undergoes proinflammatory activation in late pregnancy, promoting labor. Bromodomain and Extra-Terminal (BET) family proteins interact with…”
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The Enigma of the Adrenarche: Identifying the Early Life Mechanisms and Possible Role in Postnatal Brain Development by Cumberland, Angela L, Hirst, Jonathan J, Badoer, Emilio, Wudy, Stefan A, Greaves, Ronda F, Zacharin, Margaret, Walker, David W

“…Dehydroepiandrosterone (DHEA) and its sulfated metabolite (DHEAS) are dynamically regulated before birth and the onset of puberty. Yet, the origins and purpose…”
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Zuranolone therapy protects frontal cortex neurodevelopment and improves behavioral outcomes after preterm birth by Moloney, Roisin A., Palliser, Hannah K., Pavy, Carlton L., Shaw, Julia C., Hirst, Jonathan J.

“…Background Preterm birth is associated with brain injury and long‐term behavioral abnormalities, for which there are limited prevention options. When born…”
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Reduced Neurosteroid Exposure Following Preterm Birth and Its' Contribution to Neurological Impairment: A Novel Avenue for Preventative Therapies by Shaw, Julia C, Berry, Mary J, Dyson, Rebecca M, Crombie, Gabrielle K, Hirst, Jonathan J, Palliser, Hannah K

“…Children born preterm are at an increased risk of developing cognitive problems and neuro-behavioral disorders such as attention deficit hyperactivity disorder…”
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Progesterone receptor expression declines in the guinea pig uterus during functional progesterone withdrawal and in response to prostaglandins by Welsh, Toni N, Hirst, Jonathan J, Palliser, Hannah, Zakar, Tamas

“…Progesterone withdrawal is essential for parturition, but the mechanism of this pivotal hormonal change is unclear in women and other mammals that give birth…”
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Ganaxolone: A New Treatment for Neonatal Seizures by Yawno, Tamara, Miller, Suzie L, Bennet, Laura, Wong, Flora, Hirst, Jonathan J, Fahey, Michael, Walker, David W

“…Neonatal seizures are amongst the most common neurologic conditions managed by a neonatal care service. Seizures can exacerbate existing brain injury, induce…”
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Prenatal Stress Alters Hippocampal Neuroglia and Increases Anxiety in Childhood by Bennett, Greer A, Palliser, Hannah K, Shaw, Julia C, Walker, David, Hirst, Jonathan J

“…Prenatal stress has been associated with detrimental outcomes of pregnancy, including altered brain development leading to behavioural pathologies. The…”
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Sex-dependent effect of a low neurosteroid environment and intrauterine growth restriction on foetal guinea pig brain development by Kelleher, Meredith A, Palliser, Hannah K, Walker, David W, Hirst, Jonathan J

“…Progesterone and its neuroactive metabolite, allopregnanolone, are present in high concentrations during pregnancy, but drop significantly following birth…”
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Impaired Oligodendrocyte Development Following Preterm Birth: Promoting GABAergic Action to Improve Outcomes by Shaw, Julia C, Crombie, Gabrielle K, Palliser, Hannah K, Hirst, Jonathan J

“…Preterm birth is associated with poor long-term neurodevelopmental and behavioral outcomes, even in the absence of obvious brain injury at the time of birth…”
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Examining Neurosteroid-Analogue Therapy in the Preterm Neonate For Promoting Hippocampal Neurodevelopment by Shaw, Julia C, Dyson, Rebecca M, Palliser, Hannah K, Sixtus, Ryan P, Barnes, Heather, Pavy, Carlton L, Crombie, Gabrielle K, Berry, Mary J, Hirst, Jonathan J

“…Preterm birth can lead to brain injury and currently there are no targeted therapies to promote postnatal brain development and protect these vulnerable…”
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Newcastle 1000 (NEW1000) Study: an Australian population-based prospective pregnancy cohort study design and protocol by Grace, Tegan, Fisher, Joshua, Wang, Carol, Valkenborghs, Sarah R, Smith, Roger, Hirst, Jonathan J, Mattes, Joerg, Murphy, Vanessa E, Pennell, Craig E, Pennell, Craig, Smith, Roger, Calford, Mike, Collins, Clare, Kay-Lambkin, Frances, Scott, Rodney, Attia, John, McDonald, Vanessa, Murphy, Vanessa, Reeves, Penny, Mattes, Joerg, Gedye, Craig, Dudding-Bythe, Tracey, Wiggers, John, Talley, Nick, Keely, Simon, Foureur, Maralyn, Pringle, Kirsty, Gibson, Peter, Hoedt, Emily, Boyle, Andrew, Searles, Andrew, Horvat, Jay, Duncan, Mitch, Valkenborghs, Sarah, Campbell, Linda, Freeman, Emily

“…IntroductionMultiple cohort studies have been established to investigate the impact of early life factors on development and health outcomes. In Australia the…”
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Loss of neurosteroid-mediated protection following stress during fetal life by Hirst, Jonathan J., Cumberland, Angela L., Shaw, Julia C., Bennett, Greer A., Kelleher, Meredith A., Walker, David W., Palliser, Hannah K.

“…•Elevated neurosteroids during pregnancy have major protective and neurotrophic roles in the fetal brain.•Preterm birth and maternal stress during pregnancy…”
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Birth and Neonatal Transition in the Guinea Pig: Experimental Approaches to Prevent Preterm Birth and Protect the Premature Fetus by Hirst, Jonathan J, Palliser, Hannah K, Shaw, Julia C, Crombie, Gabrielle, Walker, David W, Zakar, Tamas

“…The guinea pig (Cavia porcellus) displays many features of gestational physiology that makes it the most translationally relevant rodent species. Progesterone…”
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Adaptations in the Hippocampus during the Fetal to Neonatal Transition in Guinea Pigs by Shaw, Julia C., Dyson, Rebecca M., Palliser, Hannah K., Crombie, Gabrielle K., Berry, Mary J., Hirst, Jonathan J.

“…(Background) The transition from in utero to ex utero life is associated with rapid changes in the brain that are both protective and required for newborn…”
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Increased allopregnanolone levels in the fetal sheep brain following umbilical cord occlusion by Nguyen, Phuong N., Yan, Edwin B., Castillo‐Melendez, Margie, Walker, David W., Hirst, Jonathan J.

“…Allopregnanolone (AP) is a potent modulator of the GABA A receptor. Brain AP concentrations increase in response to stress, which is thought to provide…”
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Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic by Morrison, Janna L., Botting, Kimberley J., Darby, Jack R. T., David, Anna L., Dyson, Rebecca M., Gatford, Kathryn L., Gray, Clint, Herrera, Emilio A., Hirst, Jonathan J., Kim, Bona, Kind, Karen L., Krause, Bernardo J., Matthews, Stephen G., Palliser, Hannah K., Regnault, Timothy R. H., Richardson, Bryan S., Sasaki, Aya, Thompson, Loren P., Berry, Mary J.

“…Over 30 years ago Professor David Barker first proposed the theory that events in early life could explain an individual's risk of non‐communicable disease in…”
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Stress in pregnancy: a role for neuroactive steroids in protecting the fetal and neonatal brain by Hirst, Jonathan J, Walker, David W, Yawno, Tamara, Palliser, Hannah K

“…Stressors during pregnancy can lead to perinatal brain injury resulting in serious neurological impairment. Neuroactive steroid concentrations are elevated…”
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Effects of prenatal stress on behavioural and neurodevelopmental outcomes are altered by maternal separation in the neonatal period by Crombie, Gabrielle K., Palliser, Hannah K, Shaw, Julia C, Hodgson, Deborah M., Walker, David W, Hirst, Jonathan J

“…•Maternal stress markedly disrupts behaviour and GABAergic/glutamatergic balance.•Mechanisms of stress-induced behavioural alterations involve myelination…”
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Blocked, delayed, or obstructed: What causes poor white matter development in intrauterine growth restricted infants? by Tolcos, Mary, Petratos, Steven, Hirst, Jonathan J, Wong, Flora, Spencer, Sarah J, Azhan, Aminath, Emery, Ben, Walker, David W

“…Poor white matter development in intrauterine growth restricted (IUGR) babies remains a major, untreated problem in neonatology. New therapies, guided by an…”
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Allopregnanolone in the brain: protecting pregnancy and birth outcomes by Brunton, Paula J, Russell, John A, Hirst, Jonathan J

“…A successful pregnancy requires multiple adaptations in the mother's brain that serve to optimise foetal growth and development, protect the foetus from…”
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