Search Results - "Hirst, Jennifer"

Global Prevalence of Chronic Kidney Disease - A Systematic Review and Meta-Analysis by Hill, Nathan R, Fatoba, Samuel T, Oke, Jason L, Hirst, Jennifer A, O'Callaghan, Christopher A, Lasserson, Daniel S, Hobbs, F D Richard

“…Chronic kidney disease (CKD) is a global health burden with a high economic cost to health systems and is an independent risk factor for cardiovascular disease…”
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Impact of patient and public involvement on enrolment and retention in clinical trials: systematic review and meta-analysis by Crocker, Joanna C, Ricci-Cabello, Ignacio, Parker, Adwoa, Hirst, Jennifer A, Chant, Alan, Petit-Zeman, Sophie, Evans, David, Rees, Sian

“…To investigate the impact of patient and public involvement (PPI) on rates of enrolment and retention in clinical trials and explore how this varies with the…”
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The need for randomization in animal trials: an overview of systematic reviews by Hirst, Jennifer A, Howick, Jeremy, Aronson, Jeffrey K, Roberts, Nia, Perera, Rafael, Koshiaris, Constantinos, Heneghan, Carl

“…Randomization, allocation concealment, and blind outcome assessment have been shown to reduce bias in human studies. Authors from the Collaborative Approach to…”
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Adaptor protein complexes and disease at a glance by Sanger, Anneri, Hirst, Jennifer, Davies, Alexandra K, Robinson, Margaret S

“…Adaptor protein (AP) complexes are heterotetramers that select cargo for inclusion into transport vesicles. Five AP complexes (AP-1 to AP-5) have been…”
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Quantifying the Effect of Metformin Treatment and Dose on Glycemic Control by HIRST, Jennifer A, FARMER, Andrew J, ALI, Raghib, ROBERTS, Nia W, STEVENS, Richard J

“…Metformin is the first-line oral medication recommended for glycemic control in patients with type 2 diabetes. We reviewed the literature to quantify the…”
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Prevalence and factors associated with multimorbidity among primary care patients with decreased renal function by Hirst, Jennifer A, Ordóñez Mena, José M, O'Callaghan, Chris A, Ogburn, Emma, Taylor, Clare J, Yang, Yaling, Hobbs, F D Richard

“…To establish the prevalence of multimorbidity in people with chronic kidney disease (CKD) stages 1-5 and transiently impaired renal function and identify…”
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Uptake, effectiveness and safety of COVID-19 vaccines in individuals at clinical risk due to immunosuppressive drug therapy or transplantation procedures: a population-based cohort study in England by Chen, Daniel Tzu-Hsuan, Copland, Emma, Hirst, Jennifer A, Mi, Emma, Dixon, Sharon, Coupland, Carol, Hippisley-Cox, Julia

“…Immunocompromised individuals are at increased risk of severe COVID-19 outcomes, underscoring the importance of COVID-19 vaccination in this population. The…”
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AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A by Davies, Alexandra K., Itzhak, Daniel N., Edgar, James R., Archuleta, Tara L., Hirst, Jennifer, Jackson, Lauren P., Robinson, Margaret S., Borner, Georg H. H.

“…Adaptor protein 4 (AP-4) is an ancient membrane trafficking complex, whose function has largely remained elusive. In humans, AP-4 deficiency causes a severe…”
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Role of the AP-5 adaptor protein complex in late endosome-to-Golgi retrieval by Hirst, Jennifer, Itzhak, Daniel N, Antrobus, Robin, Borner, Georg H H, Robinson, Margaret S

“…The AP-5 adaptor protein complex is presumed to function in membrane traffic, but so far nothing is known about its pathway or its cargo. We have used…”
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Changes in HbA1c level over a 12-week follow-up in patients with type 2 diabetes following a medication change by Hirst, Jennifer A, Stevens, Richard J, Farmer, Andrew J

“…Current guidance about the interval needed before retesting HbA1c when monitoring for glycaemic control is based on expert opinion rather than well-powered…”
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Adaptor Protein Complexes AP‐4 and AP‐5: New Players in Endosomal Trafficking and Progressive Spastic Paraplegia by Hirst, Jennifer, Irving, Carol, Borner, Georg H.H.

“…The adaptor proteins (APs) are a family of five heterotetrameric complexes with important functions in vesicle trafficking. While the roles of APs 1–3 are…”
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Performance of point-of-care HbA1c test devices: implications for use in clinical practice - a systematic review and meta-analysis by Hirst, Jennifer A, McLellan, Julie H, Price, Christopher P, English, Emma, Feakins, Benjamin G, Stevens, Richard J, Farmer, Andrew J

“…Point-of-care (POC) devices could be used to measure hemoglobin A1c (HbA1c) in the doctors' office, allowing immediate feedback of results to patients. Reports…”
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Comparative efficacy and safety of the artemisinin derivatives compared to quinine for treating severe malaria in children and adults: A systematic update of literature and network meta-analysis by Nyaaba, Nicholas, Andoh, Nana Efua, Amoh, Gordon, Amuzu, Dominic Selorm Yao, Ansong, Mary, Ordóñez-Mena, José M, Hirst, Jennifer

“…The artemisinin derivatives are the preferred antimalaria drugs for treating severe Plasmodium falciparum malaria. However, their clinical effectiveness…”
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Perceptions on undertaking regular asymptomatic self-testing for COVID-19 using lateral flow tests: a qualitative study of university students and staff by Wanat, Marta, Logan, Mary, Hirst, Jennifer A, Vicary, Charles, Lee, Joseph J, Perera, Rafael, Tracey, Irene, Duff, Gordon, Tufano, Peter, Fanshawe, Thomas, Mwandigha, Lazaro, Nicholson, Brian D, Tonkin-Crine, Sarah, Hobbs, Richard

“…ObjectivesSuccessful implementation of asymptomatic testing programmes using lateral flow tests (LFTs) depends on several factors, including feasibility,…”
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The fifth adaptor protein complex by Hirst, Jennifer, Barlow, Lael D, Francisco, Gabriel Casey, Sahlender, Daniela A, Seaman, Matthew N J, Dacks, Joel B, Robinson, Margaret S

“…Adaptor protein (AP) complexes sort cargo into vesicles for transport from one membrane compartment of the cell to another. Four distinct AP complexes have…”
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Quality of life in older adults with chronic kidney disease and transient changes in renal function: Findings from the Oxford Renal cohort by Busa, Isabella, Ordóñez-Mena, José M, Yang, Yaling, Wolstenholme, Jane, Petrou, Stavros, Taylor, Clare J, O'Callaghan, Chris A, Fraser, Simon D. S, Taal, Maarten W, McManus, Richard J, Hirst, Jennifer A, Hobbs, F. D. Richard

“…Background Quality of life (QoL) is an important measure of disease burden and general health perception. The relationship between early chronic kidney disease…”
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Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England by Copland, Emma, Patone, Martina, Saatci, Defne, Handunnetthi, Lahiru, Hirst, Jennifer, Hunt, David P. J., Mills, Nicholas L., Moss, Paul, Sheikh, Aziz, Coupland, Carol A. C., Harnden, Anthony, Robertson, Chris, Hippisley-Cox, Julia

“…The risk-benefit profile of COVID-19 vaccination in children remains uncertain. A self-controlled case-series study was conducted using linked data of 5.1…”
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Prevalence of chronic kidney disease in the community using data from OxRen: a UK population-based cohort study by Hirst, Jennifer A, Hill, Nathan, O'Callaghan, Chris A, Lasserson, Daniel, McManus, Richard J, Ogburn, Emma, Mena, José M Ordóñez, Shine, Brian, Taylor, Clare J, Vazquez-Montes, Maria Dla, Yang, Yaling, Hobbs, Fd Richard

“…Chronic kidney disease (CKD) is a largely asymptomatic condition of diminished renal function, which may not be detected until advanced stages without…”
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Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles by Borner, Georg H H, Antrobus, Robin, Hirst, Jennifer, Bhumbra, Gary S, Kozik, Patrycja, Jackson, Lauren P, Sahlender, Daniela A, Robinson, Margaret S

“…Despite recent advances in mass spectrometry, proteomic characterization of transport vesicles remains challenging. Here, we describe a multivariate proteomics…”
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Stable endocytic structures navigate the complex pellicle of apicomplexan parasites by Koreny, Ludek, Mercado-Saavedra, Brandon N., Klinger, Christen M., Barylyuk, Konstantin, Butterworth, Simon, Hirst, Jennifer, Rivera-Cuevas, Yolanda, Zaccai, Nathan R., Holzer, Victoria J. C., Klingl, Andreas, Dacks, Joel B., Carruthers, Vern B., Robinson, Margaret S., Gras, Simon, Waller, Ross F.

“…Apicomplexan parasites have immense impacts on humanity, but their basic cellular processes are often poorly understood. Where endocytosis occurs in these…”
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