Search Results - "Hirst, D. G."

Gold nanoparticles as novel agents for cancer therapy by JAIN, S, HIRST, D. G, O'SULLIVAN, J. M

“…Gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and…”
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Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapy by Butterworth, K T, Coulter, J A, Jain, S, Forker, J, McMahon, S J, Schettino, G, Prise, K M, Currell, F J, Hirst, D G

“…High atomic number (Z) materials such as gold preferentially absorb kilovoltage x-rays compared to soft tissue and may be used to achieve local dose…”
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Interstitial cells: involvement in rhythmicity and neural control of gut smooth muscle by Hirst, G. D. S., Ward, S. M.

“…Many smooth muscles display spontaneous electrical and mechanical activity, which persists in the absence of any stimulation. In the past this has been…”
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Identification of rhythmically active cells in guinea-pig stomach by Dickens, Emma J., Hirst, G. D. S., Tomita, T.

“…When intracellular recordings were made from the antral region of guinea-pig stomach, cells with different patterns of electrical activity were detected. One…”
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Role of interstitial cells of Cajal in neural control of gastrointestinal smooth muscles by Ward, S. M., Sanders, K. M., Hirst, G. D. S.

“…Specialized cells known as interstitial cells of Cajal (ICC) are distributed in specific locations within the tunica muscularis of the gastrointestinal tract…”
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Generation of slow waves in the antral region of guinea-pig stomach - a stochastic process by Hirst, G. D. S., Edwards, F. R.

“…Slow waves were recorded from the circular muscle layer of the antral region of guinea-pig stomach. Slow waves were abolished by 2APB, an inhibitor of IP 3…”
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Relationship between clonogenic radiosensitivity, radiation-induced apoptosis and DNA damage repair in human colon cancer cells by DUNNE, A. L, PRICE, M. E, MOTHERSILL, C, MCKEOWN, S. R, ROBSON, T, HIRST, D. G

“…The intrinsic radiation sensitivity of normal and tumour tissue is a major determinant of the outcome of radiotherapy. There is currently no established test…”
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Electrical Coupling between the Myenteric Interstitial Cells of Cajal and Adjacent Muscle Layers in the Guinea-Pig Gastric Antrum by Cousins, H. M., Edwards, F. R., Hickey, H., Hill, C. E., Hirst, G. D. S.

“…Intracellular recordings were made from short segments of the muscular wall of the guinea-pig gastric antrum. Preparations were impaled using two independent…”
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Involvement of intramuscular interstitial cells in nitrergic inhibition in the mouse gastric antrum by Suzuki, H., Ward, S. M., Bayguinov, Y. R., Edwards, F. R., Hirst, G. D. S.

“…Intracellular recordings were made from isolated bundles of the circular muscle layer of mouse gastric antrum and the responses evoked by stimulating intrinsic…”
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Regenerative potentials evoked in circular smooth muscle of the antral region of guinea-pig stomach by Suzuki, H., Hirst, G. D. S.

“…Slow waves recorded from the circular smooth muscle layer of guinea-pig antrum consisted of two components, an initial component and a secondary regenerative…”
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Selective knockout of intramuscular interstitial cells reveals their role in the generation of slow waves in mouse stomach by Dickens, Emma J., Edwards, F. R., Hirst, G. D. S.

“…Intracellular recording techniques were used to compare the patterns of electrical activity generated in the antral region of the stomachs of wild-type and W/W…”
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Unitary nature of regenerative potentials recorded from circular smooth muscle of guinea-pig antrum by Edwards, F. R., Hirst, G. D. S., Suzuki, H.

“…When short segments of single bundles of circular muscle of guinea-pig antrum were isolated and impaled with two microelectrodes, the membrane potential…”
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The radiation-inducible pE9 promoter driving inducible nitric oxide synthase radiosensitizes hypoxic tumour cells to radiation by Coulter, J A, McCarthy, H O, Worthington, J, Robson, T, Scott, S, Hirst, D G

“…Driving high-level transgene expression in a tumour-specific manner remains a key requirement in the development of cancer gene therapy. We have previously…”
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p21 -mediated transcriptional targeting of inducible nitric oxide synthase gene therapy sensitizes tumours to fractionated radiotherapy by MCCARTHY, H. O, WORTHINGTON, J, BARRETT, E, COSIMO, E, BOYD, M, MAIRS, R. J, WARD, C, MCKEOWN, S. R, HIRST, D. G, ROBSON, T

“…Cancer gene therapy that utilizes toxic transgene products requires strict transcriptional targeting to prevent adverse normal tissue effects. We report on the…”
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Regional variation in contribution of myenteric and intramuscular interstitial cells of Cajal to generation of slow waves in mouse gastric antrum by Hirst, G. D. S., Beckett, E. A. H., Sanders, K. M., Ward, S. M.

“…When intracellular recordings were made from the antral region of murine stomach, cells with three different patterns of electrical activity were detected. One…”
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Pacemaker shift in the gastric antrum of guinea-pigs produced by excitatory vagal stimulation involves intramuscular interstitial cells by Hirst, G. D. S., Dickens, E. J., Edwards, F. R.

“…Intracellular recordings were made from isolated bundles of the circular muscle layer of guinea-pig gastric antrum and the responses produced by stimulating…”
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An electrical description of the generation of slow waves in the antrum of the guinea-pig by Edwards, F. R., Hirst, G. D. S.

“…This paper provides an electrical description of the generation of slow waves in the guinea-pig gastric antrum. A short segment of a circular smooth muscle…”
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Tumour cell radiosensitization using constitutive (CMV) and radiation inducible (WAF1) promoters to drive the iNOS gene: a novel suicide gene therapy by WORTHINGTON, J, ROBSON, T, O'KEEFE, M, HIRST, D. G

“…Nitric oxide (NO(*)) has many characteristics including cytotoxicity, radiosensitization and anti-angiogenesis, which make it an attractive molecule for use in…”
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Mechanisms of excitatory neuromuscular transmission in the guinea-pig urinary bladder by Hashitani, H., Bramich, N. J., Hirst, G. D. S.

“…In smooth muscle of the guinea-pig bladder, either membrane potential recordings or [Ca 2+ ] i measurements were made simultaneously with isometric tension…”
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Voltage independence of vasomotion in isolated irideal arterioles of the rat by Haddock, R. E., Hirst, G. D. S., Hill, C. E.

“…The cellular mechanisms underlying vasomotion of irideal arterioles from juvenile rats have been studied using electrophysiological methods, ratiometric…”
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