Search Results - "Hirschie Johnson, Carl"

Circadian Disruption Leads to Insulin Resistance and Obesity by Shi, Shu-qun, Ansari, Tasneem S., McGuinness, Owen P., Wasserman, David H., Johnson, Carl Hirschie

“…Disruption of circadian (daily) timekeeping enhances the risk of metabolic syndrome, obesity, and type 2 diabetes. While clinical observations have suggested…”
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Diurnal Variation in SARS-CoV-2 PCR Test Results: Test Accuracy May Vary by Time of Day by McNaughton, Candace D., Adams, Nicholas M., Hirschie Johnson, Carl, Ward, Michael J., Schmitz, Jonathan E., Lasko, Thomas A.

“…False negative tests for SARS-CoV-2 are common and have important public health and medical implications. We tested the hypothesis of diurnal variation in…”
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Host circadian behaviors exert only weak selective pressure on the gut microbiome under stable conditions but are critical for recovery from antibiotic treatment by Zhao, Chi, Kelly, Kevin, Jabbur, Maria Luísa, Paguaga, Marcell, Behringer, Megan, Johnson, Carl Hirschie

“…The circadian rhythms of hosts dictate an approximately 24 h transformation in the environment experienced by their gut microbiome. The consequences of this…”
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Ube3a Imprinting Impairs Circadian Robustness in Angelman Syndrome Models by Shi, Shu-qun, Bichell, Terry Jo, Ihrie, Rebecca A., Johnson, Carl Hirschie

“…The paternal allele of Ube3a is silenced by imprinting in neurons, and Angelman syndrome (AS) is a disorder arising from a deletion or mutation of the maternal…”
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Real-time luminescence monitoring of cell-cycle and respiratory oscillations in yeast by Robertson, J. Brian, Stowers, Chris C, Boczko, Erik, Hirschie Johnson, Carl

“…The use of luciferase reporters has become a precise, noninvasive, high-throughput method for real-time monitoring of promoter activity in living cells,…”
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Timing the day: what makes bacterial clocks tick? by Johnson, Carl Hirschie, Zhao, Chi, Xu, Yao, Mori, Tetsuya

“…Key Points Bacteria exhibit daily timekeeping capabilities, including bona fide circadian rhythmicity. Circadian clock mechanisms in cyanobacteria are the best…”
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Circadian clocks and cell division: What's the pacemaker? by Johnson, Carl Hirschie

“…Evolution has selected a system of two intertwined cell cycles: the cell division cycle (CDC) and the daily (circadian) biological clock. The circadian clock…”
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Metabolic Compensation and Circadian Resilience in Prokaryotic Cyanobacteria by Johnson, Carl Hirschie, Egli, Martin

“…For a biological oscillator to function as a circadian pacemaker that confers a fitness advantage, its timing functions must be stable in response to…”
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Non-optimal codon usage is a mechanism to achieve circadian clock conditionality by Xu, Yao, Ma, Peijun, Shah, Premal, Rokas, Antonis, Liu, Yi, Johnson, Carl Hirschie

“…Central circadian proteins in cyanobacteria unexpectedly use non-optimal codons, and optimizing their codes is shown to cause a change in an adaptive response…”
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Evaluating the Adaptive Fitness of Circadian Clocks and their Evolution by Jabbur, Maria Luísa, Dani, Chitrang, Spoelstra, Kamiel, Dodd, Antony N., Johnson, Carl Hirschie

“…Surely most chronobiologists believe circadian clocks are an adaptation of organisms that enhances fitness, but are we certain that this focus of our research…”
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Revealing circadian mechanisms of integration and resilience by visualizing clock proteins working in real time by Mori, Tetsuya, Sugiyama, Shogo, Byrne, Mark, Johnson, Carl Hirschie, Uchihashi, Takayuki, Ando, Toshio

“…The circadian clock proteins KaiA, KaiB, and KaiC reconstitute a remarkable circa-24 h oscillation of KaiC phosphorylation that persists for many days in…”
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Coupling optogenetic stimulation with NanoLuc-based luminescence (BRET) Ca++ sensing by Yang, Jie, Cumberbatch, Derrick, Centanni, Samuel, Shi, Shu-qun, Winder, Danny, Webb, Donna, Johnson, Carl Hirschie

“…Optogenetic techniques allow intracellular manipulation of Ca ++ by illumination of light-absorbing probe molecules such as channelrhodopsins and melanopsins…”
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Spectres of Clock Evolution: Past, Present, and Yet to Come by Jabbur, Maria Luísa, Johnson, Carl Hirschie

“…Circadian clocks are phylogenetically widespread biological oscillators that allow organisms to entrain to environmental cycles and use their steady-state…”
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Evolution of KaiC-Dependent Timekeepers: A Proto-circadian Timing Mechanism Confers Adaptive Fitness in the Purple Bacterium Rhodopseudomonas palustris by Ma, Peijun, Mori, Tetsuya, Zhao, Chi, Thiel, Teresa, Johnson, Carl Hirschie

“…Circadian (daily) rhythms are a fundamental and ubiquitous property of eukaryotic organisms. However, cyanobacteria are the only prokaryotic group for which…”
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The Cyanobacterial Circadian System: From Biophysics to Bioevolution by Johnson, Carl Hirschie, Stewart, Phoebe L, Egli, Martin

“…Recent studies have unveiled the molecular machinery responsible for the biological clock in cyanobacteria and found that it exerts pervasive control over…”
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Eating breakfast and avoiding late-evening snacking sustains lipid oxidation by Kelly, Kevin Parsons, McGuinness, Owen P, Buchowski, Maciej, Hughey, Jacob J, Chen, Heidi, Powers, James, Page, Terry, Johnson, Carl Hirschie

“…Circadian (daily) regulation of metabolic pathways implies that food may be metabolized differentially over the daily cycle. To test that hypothesis, we…”
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Synechocystis : A model system for expanding the study of cyanobacterial circadian rhythms by Zhao, Chi, Xu, Yao, Wang, Bo, Johnson, Carl Hirschie

“…The study of circadian rhythms in bacteria was transformed by studies of the cyanobacterium . However, in a number of respects is atypical, and while those…”
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Visible light alters yeast metabolic rhythms by inhibiting respiration by Robertson, James Brian, Davis, Chris R., Johnson, Carl Hirschie

“…Exposure of cells to visible light in nature or in fluorescence microscopy often is considered to be relatively innocuous. However, using the yeast respiratory…”
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Bioluminescent Sensors for Ca ++ Flux Imaging and the Introduction of a New Intensity-Based Ca ++ Sensor by Yang, Jie, Johnson, Carl Hirschie

“…Sensitive detection of biological events is a goal for the design and characterization of sensors that can be used and . One important second messenger is Ca…”
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Circadian Clocks: Unexpected Biochemical Cogs by Mori, Tetsuya, Mchaourab, Hassane, Johnson, Carl Hirschie

“…A circadian oscillation can be reconstituted in vitro from three proteins that cycles with a period of ∼ 24 h. Two recent studies provide surprising…”
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