Search Results - "Hirschi, Marscha"

AcrIF9 tethers non-sequence specific dsDNA to the CRISPR RNA-guided surveillance complex by Hirschi, Marscha, Lu, Wang-Ting, Santiago-Frangos, Andrew, Wilkinson, Royce, Golden, Sarah M., Davidson, Alan R., Lander, Gabriel C., Wiedenheft, Blake

“…Bacteria have evolved sophisticated adaptive immune systems, called CRISPR-Cas, that provide sequence-specific protection against phage infection. In turn,…”
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Conformational ensemble of the human TRPV3 ion channel by Zubcevic, Lejla, Herzik, Mark A., Wu, Mengyu, Borschel, William F., Hirschi, Marscha, Song, Albert S., Lander, Gabriel C., Lee, Seok-Yong

“…Transient receptor potential vanilloid channel 3 (TRPV3), a member of the thermosensitive TRP (thermoTRPV) channels, is activated by warm temperatures and…”
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A case for glycerol as an acceptable additive for single‐particle cryoEM samples by Basanta, Benjamin, Hirschi, Marscha M., Grotjahn, Danielle A., Lander, Gabriel C.

“…Buffer‐composition and sample‐preparation guidelines for cryo‐electron microscopy are geared towards maximizing imaging contrast and reducing…”
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Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA by Kuhle, Bernhard, Hirschi, Marscha, Doerfel, Lili K., Lander, Gabriel C., Schimmel, Paul

“…Human mitochondrial gene expression relies on the specific recognition and aminoacylation of mitochondrial tRNAs (mtRNAs) by nuclear-encoded mitochondrial…”
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Structural basis for a degenerate tRNA identity code and the evolution of bimodal specificity in human mitochondrial tRNA recognition by Kuhle, Bernhard, Hirschi, Marscha, Doerfel, Lili K., Lander, Gabriel C., Schimmel, Paul

“…Animal mitochondrial gene expression relies on specific interactions between nuclear-encoded aminoacyl-tRNA synthetases and mitochondria-encoded tRNAs. Their…”
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Discovery of a Novel Mode of Protein Kinase Inhibition Characterized by the Mechanism of Inhibition of Human Mesenchymal-epithelial Transition Factor (c-Met) Protein Autophosphorylation by ARQ 197 by Eathiraj, Sudharshan, Palma, Rocio, Volckova, Erika, Hirschi, Marscha, France, Dennis S., Ashwell, Mark A., Chan, Thomas C.K.

“…A number of human malignancies exhibit sustained stimulation, mutation, or gene amplification of the receptor tyrosine kinase human mesenchymal-epithelial…”
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Visualizing multistep elevator-like transitions of a nucleoside transporter by Hirschi, Marscha, Johnson, Zachary Lee, Lee, Seok-Yong

“…Membrane transporters move substrates across the membrane by alternating access of their binding sites between the opposite sides of the membrane. An emerging…”
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Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3 by Hirschi, Marscha, Herzik Jr, Mark A., Wie, Jinhong, Suo, Yang, Borschel, William F., Ren, Dejian, Lander, Gabriel C., Lee, Seok-Yong

“…A cryo-electron microscopy structure shows that the mucolipin domain of the lysosomal calcium channel TRPML3 binds phosphatidylinositol-3,5-bisphosphate and…”
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An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes by Zhang, Yuanjin, Liu, Zhonglin, Hirschi, Marscha, Brodsky, Oleg, Johnson, Eric, Won, Sang Joon, Nagata, Asako, Bezwada, Divya, Petroski, Matthew D, Majmudar, Jaimeen D, Niessen, Sherry, VanArsdale, Todd, Gilbert, Adam M, Hayward, Matthew M, Stewart, Al E, Nager, Andrew R, Melillo, Bruno, Cravatt, Benjamin F

“…More than half of the ~20,000 protein-encoding human genes have paralogs. Chemical proteomics has uncovered many electrophile-sensitive cysteines that are…”
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Conformational Ensemble of the Human TRPV3 Ion Channel by Zubcevic, Lejla, Herzik, Mark A., Wu, Mengyu, Borschel, William F., Hirschi, Marscha, Song, Albert, Lander, Gabriel C., Lee, Seok-Yong

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Cryo-EM structure of the lysosomal Ca2+-permeable channel TRPML3 by Hirschi, Marscha, Herzik, Mark A., Wie, Jinhong, Suo, Yang, Borschel, William F., Ren, Dejian, Lander, Gabriel C., Lee, Seok-Yong

“…The modulation of ion channel activity by lipids is increasingly recognized as a fundamental component of cellular signaling. The mucolipin transient receptor…”
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Structural and Functional Studies of Nucleoside Transporters by Hirschi, Marscha

“…Nucleoside transport is required for the salvage pathway of DNA and RNA, provides a transport route for nucleoside-like drugs and regulates adenosine…”
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A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor by Eathiraj, Sudharshan, Palma, Rocio, Hirschi, Marscha, Volckova, Erika, Nakuci, Enkeleda, Castro, Jennifer, Chen, Chang-Rung, Chan, Thomas C K, France, Dennis S, Ashwell, Mark A

“…Protein kinase inhibitors with enhanced selectivity can be designed by optimizing binding interactions with less conserved inactive conformations because such…”
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Guidelines for Antisense Oligonucleotide Design and Insight Into Splice-modulating Mechanisms by Aartsma-Rus, Annemieke, van Vliet, Laura, Hirschi, Marscha, Janson, Anneke AM, Heemskerk, Hans, de Winter, Christa L, de Kimpe, Sjef, van Deutekom, Judith CT, 't Hoen, Peter AC, van Ommen, Gert-Jan B

“…Antisense oligonucleotides (AONs) can interfere with mRNA processing through RNase H–mediated degradation, translational arrest, or modulation of splicing. The…”
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A Novel Mode of Protein Kinase Inhibition Exploiting Hydrophobic Motifs of Autoinhibited Kinases by Eathiraj, Sudharshan, Palma, Rocio, Hirschi, Marscha, Volckova, Erika, Nakuci, Enkeleda, Castro, Jennifer, Chen, Chang-Rung, Chan, Thomas C.K., France, Dennis S., Ashwell, Mark A.

“…Protein kinase inhibitors with enhanced selectivity can be designed by optimizing binding interactions with less conserved inactive conformations because such…”
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